Clinical trials: sponsored by University Hospital, Lille
Doose Syndrome, Epileptic Syndromes
The Becoming of Children With Doose Syndrome
Doose syndrome is a rare epileptic syndrome that can lead to learning difficulties and a poor quality of life. The goal of this study is to evaluate the evolution of epilepsy and its consequences on cognitive development and…
- Conditions
- Doose Syndrome, Epileptic Syndromes, Learning Disabilities
- Trial name
- DOOSE (NCT04048213)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Iatrogenesis, Clinical Vignettes
Evaluation of the POSOS Device for Iatrogenesis Detection in Clinical History? A Vignettes Study
This study is a multicenter evaluation of diagnostic performance using simulated clinical vignettes. It aims to test the effectiveness of the POSOS app in detecting drug-induced iatrogenesis in urgent medical situations, an issue…
- Conditions
- Iatrogenesis, Clinical Vignettes, Diagnostic Performance Study, Medical Information Search
- Trial name
- YGenHiVi (NCT05952193)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Diaphragmatic Paralysis
Interscalene Block and Dysfunction Diaphragmatic
The study seeks to show that interscalene injection of a small volume (<8ml) of ropivacaine at a low concentration (0.1%) reduces the frequency of hemi-diaphragmatic paresis compared to low volume injection at the standard…
- Trial name
- NUMEROBIS (NCT04173364)
- Testing
- Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.1% Injectable Solution
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Obesity
Evaluation of Liver Fibrosis Following Surgical-induced Weight Loss
Obesity is a frequent disease with an increased prevalence, estimated to 12.4% in France (OBEPI study 2006). Non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) both complicate morbid obesity and…
- Trial name
- FIBROTEST (NCT01469962)
- Testing
- Surgical procedure
- Where
- France
- Volunteers
- 255 people
- Sponsor
- University Hospital, Rouen
Inflammation in Cardiac Surgery
Hydrocortisone Plus Fludrocortisone in High-risk Patients Undergoing for Cardiac Surgery
Cardiac surgery is a high-risk surgery and is associated with a rate of postoperative adverse outcomes. Like many others major surgery, cardiac surgery procedures induce a proinflammatory phase usually counterbalanced with an…
- Trial name
- VASOCORT (NCT07037043)
- Testing
- hydrocortisone plus fludrocortisone
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gestational Diabetes
Early Gestational Diabetes Mellitus
In 2010, the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) panel published consensus-based recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
- Trial name
- LEMA_GDM (NCT04451915)
- Testing
- late management strategy, early management strategy
- Where
- 10 sites in France
- Volunteers
- 2,010 people
- Sponsor
- University Hospital, Lille
Alcoholic Hepatitis
PROlonged Corticosteroid Treatment or N-ACetylcysteine for Severe Alcoholic Hepatitis
Only patients suffering from a severe form of alcoholic hepatitis (Maddrey's discriminant function greater than 32) require medical treatment.
- Trial name
- PROCORNAC (NCT06956482)
- Testing
- N-Acetylcysteine (NAC) Treatment, Prednisolone, Prednisolone 10mg
- Where
- France
- Volunteers
- 477 people
- Sponsor
- University Hospital, Lille
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Stroke
DIROXIMEL FUMARATE TO REDUCE PERIHAEMATOMAL OEDEMA IN INTRACEREBRAL HAEMORRHAGE: DOUBLE BLIND RANDOMIZED CLINICAL TRIAL
Spontaneous intracerebral haemorrhage (ICH) is a life-threatening condition, still devoided of specific treatment. Peri-haematomal oedema (PHO) develops in the ensuing days after ICH onset and worsens functional outcome.
- Trial name
- DARLENE (NCT07275515)
- Testing
- DRF
- Where
- France
- Volunteers
- 192 people
- Sponsor
- University Hospital, Lille
Fall
Contribution of Peripheral Vision in the Risk of Falls in the Elderly
This study is a controlled, open-label biomedical research project in cognitive neuroscience designed to examine the results (postural stability, error rates, and spatiotemporal parameters of eye movements and head movements) of…
- Trial name
- NCT07608263
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Schizophrenia
Research Sense of Familiarity in Psychotic Patients
Categorical perception of familiarity in schizophrenic patients
- Trial name
- NCT07608250
- Testing
- cognitive test
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Cancer, Hematologic Malignancy
Identifying Cellular and Molecular Determinants of Efficacy and Resistance in Patients Undergoing CAR-T Therapy
In recent years we have witnessed a breakthrough in the treatment of leukemia and lymphoma using autologous CAR-T cells that can induce durable remission in patients.
- Trial name
- CAR-Lille (NCT07609485)
- Where
- 2 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Lille
Urinary Incontinence
Development of a Cardiac Signal Analysis Algorithm for Bladder Filling Assessment: Pilot Study
The puropose of this clinical trial is to build a database of signals issued from the device to delvelop signal processing algorithms to calculat the LFVI.
- Trial name
- ENURESIA 1 (NCT07607652)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Cutaneous Squamous Cell Carcinoma (CSCC)
Follow-up of a French National Cohort of Patients With Cutaneous Squamous Cell Carcinoma Requiring Systemic Treatment.
In the context where advanced cutaneous squamous cell carcinoma (cSCC) is currently a public health issue due to its increasing incidence and where its management is rapidly evolving, it is essential to characterize and monitor…
- Trial name
- CAREPI (NCT07606508)
- Testing
- Systemic treatment
- Where
- 29 sites in France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Lille
Malocclusions
Genetic Basis of Musculoskeletal Status Malocclusions
Genetic basis of musculoskeletal status malocclusions
- Trial name
- NCT07605910
- Sponsor
- University Hospital, Lille
Emphysema
Lung Disease and FLNA Mutations
Some sparse scientific data support the hypothesis that otherwise unexplained emphysema may be associated with FLNA variants. This transversal multicentric study aimed to describe the frequency of emphysema in patients carrying…
- Trial name
- FLN-Air (NCT07592637)
- Testing
- Radiation: Chest HRCT
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Lille
Keratosis, Actinic Keratoses
Efficacy and Safety of Cryotherapy Followed by Tirbanibulin Ointment for Actinic Keratosis on the Scalp and Forehead
The aim of the study is to evaluate the efficacy and safety of a combined approach of cryotherapy and tirbanibulin for the treatment of actinic keratosis of the scalp and forehead, repeated every 4 months.
- Trial name
- TIRBACRYO (NCT07273656)
- Testing
- Cryotherapy + Tirbanibulin
- Volunteers
- 59 people
- Sponsor
- University Hospital, Lille
Hyperglycaemia (Diabetic), Bariatric Surgery Candidate
Perioperative Evaluation of Glucose Profile Using Continuous Glucose Monitoring System in Glucose Intolerant Patients
The recent use of a pre-operative carbohydrate loading compared to fasting has been shown to improve the early recovery after surgical procedures by reducing the profound stress response following surgery and allowing a better…
- Trial name
- PERISURG-CGM (NCT04343040)
- Testing
- carbohydrate supplement (Preload™), 6 hours of preoperative fasting
- Sponsor
- University Hospital, Lille
Pediatric Cancer, Chronic Sinusitis
Post-radiotherapy Rhinosinusitis in Children
Chronic rhinosinusitis (CRS) is a frequent complication of facial cancer treatment, mainly related to radiotherapy. However, while radiological involvement is frequent, clinical expression seems less important.
- Trial name
- PRRSC (NCT05454163)
- Testing
- SNOT 22 questionnaire
- Sponsor
- University Hospital, Lille
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille