Clinical trials: sponsored by University of Calgary
Critical Illness
Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness
Patients requiring life support therapies in intensive care units are at very high risk of hospital-acquired infections. An important source of these infections is the accumulation of pathogenic bacteria in the microbiome of…
- Trial name
- MicroMod (NCT07813507)
- Testing
- Synbiotic, Standard of Care (SOC)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Foreign Body Airway Obstruction
Prospective Evaluation of Foreign Body Airway Obstruction Interventions Among Infants
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07348848
- Testing
- Chest compressions/thrusts, Back blows, Abdominal Thrusts
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- University of Calgary
Persisting Symptoms After Concussion
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy
The goal of this randomized controlled trial is to evaluate the safety, feasibility, and efficacy of psilocybin assisted therapy as an intervention to reduce symptom burden in adult patients (aged 18-65) with persisting symptoms…
- Trial name
- PatACT (NCT06615908)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Foreign Body Airway Obstruction
Prospective Evaluation of Foreign Body Airway Obstruction Interventions Among Adults and Children
Foreign body airway obstruction (FBAO, choking) is a life-threatening emergency requiring time-sensitive treatment to prevent severe injury or deaths.
- Trial name
- NCT07365137
- Testing
- Abdominal thrust, Back blows, Chest compressions/thrusts
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Calgary
Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV)
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
The goal of this randomized controlled trial is to evaluate the efficacy of psilocybin administered with Acceptance and Commitment Therapy (ACT) as an intervention to reduce post-traumatic stress disorder (PTSD) symptom burden in…
- Trial name
- PsiPTSD (NCT06885996)
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- University of Calgary
Investigating the Importance of the Subjective Psychedelic Experience
Subjective Experience Following Psilocybin
The purpose of this study is to determine the importance of the acute subjective experience induced by psilocybin (the primary component of "magic mushrooms") in facilitating positive outcomes.
- Trial name
- SEP-1 (NCT06768944)
- Testing
- Psilocybin high-dose, Psilocybin low-dose, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Unruptured Cerebral Aneurysm
Evaluating Oral Peri-operative Acetylsalicylic Acid in Subjects Undergoing Endovascular Coiling-only of Unruptured Brain Aneurysms
This trial is a is a prospective, randomized (1:1) placebo-controlled, clinical trial with blinded endpoint assessment of 440 participants with unruptured brain aneurysm planned for endovascular treatment using coiling-only…
- Trial name
- EVOLVE (NCT04192955)
- Testing
- Acetyl Salicylate
- Where
- 9 sites in Canada, France
- Volunteers
- 440 people
- Sponsor
- University of Calgary
Advanced Cancer, Demoralization
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
This pilot clinical trial will study psilocybin-assisted therapy for adults with advanced cancer who are experiencing demoralization, existential distress, or related psychological concerns.
- Conditions
- Advanced Cancer, Demoralization, Existential Distress, Psychological Distress
- Trial name
- PAT-MIND (NCT07791901)
- Testing
- PEX010 25 mg psilocybin, PEX010 5 mg psilocybin, Standard Psilocybin-Assisted Therapy
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Growth Hormone Deficiency, Traumatic Brain Injury
Charactertizing Growth Hormone Deficiency in Traumatic Brain Injury
The goal of this observational study is to characterize the impact of growth hormone deficiency (GHD) on quality of life, symptom burden, and sleep in adults with traumatic brain injury (TBI), and to evaluate whether these…
- Trial name
- NCT07795736
- Testing
- Not applicable (observational study)
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Depression / Major Depressive Disorder, Bipolar Disorder (BD)
Identifying Biomarkers of Response to Digital Interventions for Mood Disorders
The proposed study will be a single-arm pragmatic clinical trial examining the feasibility of online CBT within the CAN-BIND sites and the biomarkers of treatment response to online CBT for mood disorders.
- Trial name
- CAN-BIND-iCBT (NCT07783633)
- Testing
- Online Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre for Addiction and Mental Health
Pelvic Organ Prolapse
How Low Can You Go
This is a randomized controlled trial to determine if lower intraabdominal operating pressure reduces post-operative pain in patients scheduled to undergo laparoscopic uterosacral suspension surgery of the uterus or vaginal vault.
- Trial name
- NCT07786337
- Testing
- Standard insufflation, Low insufflation
- Volunteers
- 164 people
- Sponsor
- University of Calgary
Migraine, Migraine Headache
Neuromodulation During the Prodrome to Prevent Disabling Migraine Attacks in Youth
Background \& Rationale: One in ten Canadian youth have migraine, a disabling neurological disease that is more common in females and characterized by moderate-severe disabling headaches.
- Trial name
- NCT07772427
- Testing
- Active Remote Electrical Neuromodulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Breast Cancer Female
A Study to Identify Breast Cancer (IDBC)
Detecting cancer as early as possible is key to achieving positive outcomes in response to diagnosis and treatment. The current project is aimed at validating a novel blood-based breast cancer identification test (Syantra DX…
- Trial name
- IDBC (NCT04495244)
- Testing
- Syantra DX Breast Cancer
- Where
- 4 sites in Canada, South Korea and 1 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Syantra Inc.
Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty
Continuous Interscalene Blocks and Rebound Pain
The primary objectives of this present study are to examine whether a continuous interscalene block of a total duration of 48 hours reduces the incidence of rebound pain comparatively to single-shot interscalene block, through…
- Conditions
- Total Shoulder Arthroplasty, Reverse Total Shoulder Arthroplasty, Interscalene Analgesia, Interscalene Blocks
- Trial name
- NCT07770165
- Testing
- Continuous interscalene nerve block, Interscalene Block
- Where
- Canada
- Volunteers
- 154 people
- Sponsor
- University of Calgary
Stroke, Acute, Carotid Stenosis
Endovascular Acute Stroke Intervention - Tandem OCclusion Trial
Patients with tandem occlusion or tandem lesion (TL), that is, stroke with an acute intracranial anterior circulation occlusion and an ipsilateral cervical ICA (c-ICA) high-grade stenosis or occlusion, constitute about 15-20% of…
- Conditions
- Stroke, Acute, Carotid Stenosis, Carotid Artery Diseases
- Trial name
- EASI-TOC (NCT04261478)
- Testing
- Carotid artery stenting, Antiplatelet Agents
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Allergic Contact Dermatitis
Reliability of Expired Allergens in Patch Testing: A Comparative Study With Non-Expired Series
Patch testing remains the gold standard in the diagnosis of allergic contact dermatitis. Patches used in testing consist of a wide spectrum of allergens, with variability in the stability of products over time.
- Trial name
- NCT07765563
- Testing
- Patch 1 (Expired), Patch 2 (non-expired)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Alveolar Soft Part Sarcoma (ASPS), Sarcoma
A Study to Determine the Safety and Effectiveness of the Investigational Cellular Therapy GCAR1 in a Patient With Alveolar Soft Part Sarcoma
A single patient study to determine whether GCAR1 is safe and effective for refractory, progressive metastatic alveolar soft part sarcoma (ASPS).
- Trial name
- SPS-C (NCT07104682)
- Testing
- GCAR1
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary