Clinical trials: sponsored by University of Chicago
Ulnar Nerve Transposition
Is Splinting After Ulnar Nerve Transposition Necessary?
The goal of this clinical trial is to learn whether patient recovery after ulnar nerve transposition (UNT) requires a splint. The main questions it aims to answer are: Does the effect that early versus delayed mobilization after…
- Trial name
- NCT07880470
- Testing
- Stiff splint, No splint
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Lymphoma, B-Cell, Multiple Myeloma
Microbiome Intervention for CAR-T Optimization and Response (MICRO-CART)
Chimeric Antigen Receptor T-Cell (CAR-T) therapy has transformed the management of large B-cell lymphoma, and multiple myeloma by achieving remarkable responses, yet inconsistent durability and severe toxicities remain major…
- Trial name
- (MICRO-CART) (NCT07871747)
- Testing
- Live Biotherapeutic Product (LBP)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Cannabis Use, Substance Use Disorder (SUD)
Research Investigating Drug Effects-2 (RiDE-2)
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs.
- Conditions
- Cannabis Use, Substance Use Disorder (SUD), Healthy
- Trial name
- RiDE-2 (NCT06758596)
- Testing
- THC
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Benign Prostatic Hyperplasia (BPH)
The FLOW Registry.
The purpose of this study is to create a database and prospective registry for data collection on patients with benign prostatic hyperplasia undergoing Aquablation of the prostate.
- Trial name
- NCT07430423
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Chicago
Kidney Cancer
Randomized Evaluation of Patients Who Have Had Laparoscopic Partial Nephrectomy
The purpose of this study is to evaluate the necessity of using hemostatic agents as a tool when performing robotic partial nephrectomy in the treatment of kidney cancer.
- Trial name
- NCT04120805
- Testing
- Hemostatic Agent, No Hemostatic Agent
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Chicago
Type 2 Diabetes Mellitus (T2DM), Diabetes Distress
Achieving Routine Intervention and Screening for Emotional Health
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
- Trial name
- ARISE (NCT06887049)
- Testing
- ARISE Learning Community Diabetes Distress Screening and Intervention, ARISE Enhanced Care brief training
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- University of Chicago
Premature Birth, Infant, Premature
Parent-Facilitated Early Oral-Sensory Experience in the NICU for Feeding Outcomes
The purpose of this study is to evaluate the feasibility, acceptability, and preliminary effects of the Parent-Facilitated Early Oral-Sensory Experience (PEOE) program for very preterm infants in the Neonatal Intensive Care Unit…
- Conditions
- Premature Birth, Infant, Premature, Infant, Very Premature
- Trial name
- NCT07883707
- Testing
- Parent-Facilitated Early Oral-Sensory Experience (PEOE)
- Volunteers
- 60 people
- Sponsor
- Boston College
Ulcerative Colitis (UC)
STOP-UC: De-escalation of Therapy in Patients With Ulcerative Colitis With Histological Remission
The goal of this study is to better understand treatment strategies for people with ulcerative colitis (UC). Researchers will compare patients with UC in histologic remission (no evidence of inflammation or active disease on…
- Trial name
- NCT06693310
- Testing
- de-escalation or discontinuation of therapy, continuation of current therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Acute Pancreatitis
iMmune SignAtures and Clinical outComes in AP
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP).
- Trial name
- MoSAIC (NCT05878236)
- Testing
- CyTOF Analysis
- Where
- 5 sites in United States
- Volunteers
- 198 people
- Sponsor
- Ohio State University
Pediatric Surgery, Informed Consent
Risk Sharing vs Risk Dumping: Parental Attitudes About Risks
This study will evaluate how parents or legal guardians perceive responsibility for surgical risk after the informed consent discussion for their child's operation, focusing on whether the process feels like "risk sharing" with…
- Conditions
- Pediatric Surgery, Informed Consent, Shared Decision-making, Parental Decision Making for Seriously Ill Children
- Trial name
- NCT07875712
- Testing
- Research data collection only
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Parkinson Disease, Prodromal Stage
Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage
The goal of this clinical trial is two-fold. First to investigate the feasibility of whether a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in individuals with a…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Basal Ganglia Diseases
- Trial name
- Slow-SPEED (NCT06993142)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Obesity, Hypertension
HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental Disabilities
The barriers faced by people with intellectual and developmental disabilities (IDD) begin in their mid to late 20s and often mirror the experiences of older adults (50+) living in the U.S.
- Conditions
- Obesity, Hypertension, Hypercholesterolemia, Hyperglycemia
- Trial name
- HM@24/7 (NCT03206164)
- Testing
- Asynchronous, eLearning Intervention
- Where
- United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Renal Insufficiency, Chronic
SDCC - Prospective Cohort Study of Chronic Renal Insufficiency
Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and…
- Trial name
- CRIC (NCT00304148)
- Where
- 12 sites in United States
- Volunteers
- 5,499 people
- Sponsor
- University of Pennsylvania
Obesity, Morbid, Time Restricted Eating
Time-restricted Eating Among Pregnant Females With Severe Obesity
In the United States, a body mass index (BMI) of at least 35.0 kg/m2 affects about 15% of women of reproductive age. Severe obesity is a significant predictor of adverse perinatal outcomes including gestational diabetes mellitus…
- Conditions
- Obesity, Morbid, Time Restricted Eating, Pregnancy Weight Gain
- Trial name
- TRE-Preg (NCT06477120)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes
The study is a Phase II clinical trial. Patients will receive intensity modulated total marrow irradiation (TMI) at a dose of 9 Gy with standard myeloablative fludarabine/ i.v.
- Trial name
- NCT03121014
- Testing
- Fludarabine, Busulfan, ATG
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Illinois Chicago
Alzheimer s Disease, Dementia
CommunityRx-Dementia + Peer Navigation (CRxDpeer)
The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and…
- Conditions
- Alzheimer s Disease, Dementia, Caregiver, Loneliness
- Trial name
- CRxDpeer (NCT07346183)
- Testing
- CommunityRx-Dpeer
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Nutrition, Health
Nutrition for Precision Health, Powered by the All of Us
The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence/Machine Learning (AI/ML) algorithms that predict individual responses to diet patterns using rich…
- Conditions
- Nutrition, Health, Dietary Habits
- Trial name
- NCT05701657
- Testing
- Diet A, Diet B, Diet C
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Colorectal (Colon or Rectal) Cancer
Collagenase Biobank Study
The purpose of this study is to look at how bacteria present within the stool at the time of surgery and postoperatively may contribute to the development of cancer recurrence after surgery.
- Trial name
- NCT07211230
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Chicago
Opioid Use Disorder
Integrating MOUD in Nonmedical Community Settings (Better Together)
A multisite effectiveness-implementation study will be conducted in four sites to evaluate interventions to improve engagement and retention in MOUD with buprenorphine treatment persons with Opioid Use Disorder (OUD) in urban…
- Trial name
- NCT06416020
- Testing
- HC-MOUD Only, BT-MOUD with Buprenorphine
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Howard University
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