Clinical trials: sponsored by Vanderbilt University Medical Center
Postural Tachycardia Syndrome, Orthostatic Intolerance
Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)
We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects.
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders
- Trial name
- NCT00692471
- Testing
- Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Blood Pressure, Cardiac Transplantation
Oral Water Ingestion in Heart Transplant Patients
In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
- Trial name
- NCT00581321
- Testing
- water
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Satish R. Raj
Ehlers-Danlos Syndrome, Anesthesia, Local
Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers.
- Trial name
- NCT04036305
- Testing
- 0.9% Sodium Chloride Injection, Lidocaine Injection 2%, Bupivacaine Injection 0.5%
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Orthostatic Hypotension
Water and the Gastropressor Response - Diurnal Variability
We will test the null hypothesis that there is no diurnal (morning to afternoon)variability in the blood pressure response to the ingestion of water 16 oz.
- Trial name
- NCT00581373
- Testing
- water 16 fl oz
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Satish R. Raj
Postural Tachycardia Syndrome
Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT01000350
- Testing
- Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Rheumatic Heart Disease
Artificial Intelligence to Scale Early Rheumatic Heart Disease Detection
The main goal of this project is to see if RADAR (Rapid AI-assisted Detection and Analysis of Rheumatic heart disease), which is a machine and deep-learning AI model, can help make rheumatic heart disease (RHD) screening easier…
- Trial name
- SHIELD 1 (NCT07599956)
- Testing
- AI assisted echocardiography
- Where
- Uganda
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Tachycardia, Chronic Orthostatic Intolerance
Treatment of Orthostatic Intolerance
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with…
- Trial name
- NCT00262470
- Testing
- Acetazolamide, Atomoxetine, NO Drug
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Postural Orthostatic Tachycardia Syndrome
Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome
In this pilot study, the investigators will test the hypothesis that patients with postural tachycardia syndrome will have an elevated percentage of functional antibodies to adrenergic receptors compared with control subjects…
- Trial name
- NCT02196376
- Testing
- History, Physical, blood draw
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pulmonary Hypertension
Activity Monitoring in Pulmonary Hypertension
This is a prospective, longitudinal, observational study of free-living activity trackers and patient reported outcomes to test the hypothesis that daily activity will have stronger prognostic value than 6MWD in patients with…
- Trial name
- NCT04101630
- Testing
- Activity Monitoring
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Bilateral Sensorineural Hearing Loss
Effect of Donepezil on Speech Recognition in Cochlear Implant Users
Hearing loss is a major cause of disability that affects over 48 million Americans. There are currently no medications used to treat sensorineural hearing loss.
- Trial name
- NCT05438264
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Nutrition, Health
Nutrition for Precision Health, Powered by the All of Us
The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence/Machine Learning (AI/ML) algorithms that predict individual responses to diet patterns using rich…
- Conditions
- Nutrition, Health, Dietary Habits
- Trial name
- NCT05701657
- Testing
- Diet A, Diet B, Diet C
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- RTI International
STOMACH NEOPLASM
Use of Pyrvinium to Reverse Stomach Precancerous Conditions
This study is carried out to find out if a drug called pyrvinium is able to convert pre-cancerous tissue in the stomach back to healthy tissue, to lower the chances of stomach cancer.
- Trial name
- NCT06782048
- Testing
- Pyrvinium, Blood biomarkers analyses, Oesophagogastroduodenoscopy (OGD) and biopsy
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National University Hospital, Singapore
POTS - Postural Orthostatic Tachycardia Syndrome
Restoring Iron Deficiency in POTS
People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body).
- Trial name
- NCT07197905
- Testing
- Intravenous iron
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Huntington Disease
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease
The objective of the study is to validate the use of wearable sensors and digital health technologies for monitoring disease activity in Huntington's Disease (HD).
- Trial name
- BioDigit HD-02 (NCT07315984)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- BioSensics
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Ventricular Tachycardia
A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.
This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology…
- Trial name
- NCT04134845
- Testing
- Dantrolene/Ryanodex
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Vanderbilt University Medical Center
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Cognitive Impairment, Disability Physical
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study
The COgnitive and Physical Exercise to improve Outcomes after Surgery (COPE-iOS) study is testing the hypothesis that a pragmatic program combining computerized cognitive training and physical training throughout the…
- Conditions
- Cognitive Impairment, Disability Physical, Surgery
- Trial name
- COPEiOS (NCT04889417)
- Testing
- Comprehensive training program, Active control
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt University Medical Center
Sickle Cell Disease, Pulmonary Disease
Cooperative Assessment of Late Effects for SCD Curative Therapies
Sickle Cell Disease is one of the most common genetic diseases in the United States, occurring in approximately 1 in 400 births. Approximately 100,000 individuals are diagnosed with SCD in the United States.
- Conditions
- Sickle Cell Disease, Pulmonary Disease, Renal Disease, Heart Disease
- Trial name
- COALESCE (NCT05153967)
- Where
- 5 sites in United States
- Volunteers
- 377 people
- Sponsor
- Vanderbilt University Medical Center