Clinical trials: sponsored by West China Hospital
Unresectable Hepatocellular Carcinoma
Safety and Efficacy of Folic Acid Combined With Atezolizumab and Bevacizumab as First-Line Therapy for Unresectable Hepatocellular Carcinoma
This study is evaluating the safety and potential effectiveness of adding folic acid to atezolizumab plus bevacizumab as first-line treatment for adults with unresectable hepatocellular carcinoma (HCC).
- Trial name
- NCT07835737
- Testing
- Folic Acid, Atezolizumab & Bevacizumab
- Volunteers
- 78 people
- Sponsor
- West China Hospital
HPV-positive Oropharyngeal Squamous Cell Carcinoma
Intranasal WSK-IM05 Vaccine Plus Tislelizumab as Neoadjuvant Therapy for HPV+ OPSCC
This phase I, open-label, single-arm trial uses a "3+3" dose-escalation design to evaluate the safety, tolerability, and preliminary efffcacy of intranasal WSK-IM05 vaccine combined with tislelizumab as neoadjuvant therapy in…
- Trial name
- NCT07565740
- Testing
- WSK-IM05 (4×10^10 vp), WSK-IM05 (8×10^10 vp), WSK-IM05 (1.6x10^11 vp)
- Where
- China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Infantile Hemangioma
Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma
The main objective of this study was to determine the efficacy of different doses of propranolol in the treatment of ulcerattion infantile hemangioma (IH).
- Trial name
- NCT06798363
- Testing
- propranolol
- Where
- 3 sites in China
- Volunteers
- 32 people
- Sponsor
- West China Hospital
Advanced Melanoma
Au-TMP and Radiotherapy for Advanced Melanoma With Anti-PD-1 Therapy
Advanced melanoma is a highly aggressive malignancy that frequently exhibits resistance to conventional radiotherapy and single-agent immunotherapy.
- Trial name
- NCT07562841
- Testing
- Au-TMP, Fractionated Radiotherapy (RT), Toripalimab
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- West China Hospital
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Biliary Tract Cancer
HAIC Rechallenge in Biliary Tract Cancer and Colorectal Cancer Liver Metastases: Efficacy and Safety in Patients Resistant to Previous Systemic Chemotherapy
Plain Language Summary This study uses hepatic arterial infusion chemotherapy (HAIC) rechallenge for patients with biliary tract cancer or colorectal cancer liver metastases whose disease has progressed after previous systemic…
- Trial name
- NCT07830147
- Testing
- Hepatic Arterial Infusion Chemotherapy (HAIC) Rechallenge
- Where
- China
- Volunteers
- 72 people
- Sponsor
- West China Hospital
Head and Neck Squamous Cell Carcinoma
Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC
Head and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, as over 60% of patients are diagnosed at a locally advanced stage with a high risk of recurrence.
- Trial name
- NCT07572864
- Testing
- Engineered Mitochondrial Vaccine (IMP3-Mito), Immune checkpoint inhibitor (ICI)
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Thyroid Cancer, Thyroid Nodule
Educational Videos for Thyroid Surgery Patient
The researchers aim to evaluate the performance of two groups of participants after receiving traditional education-one group supplemented with video-based education and the other without.
- Conditions
- Thyroid Cancer, Thyroid Nodule, TSH, Education of Patients
- Trial name
- NCT07823543
- Testing
- Thyroid Surgery Educational Video
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Head and Neck Neoplasms, Cancer-related Fatigue
Tai Chi for Cancer-Related Fatigue During Radiotherapy in Patients With Head and Neck Cancer
This prospective, randomized controlled study will evaluate whether a Tai Chi exercise program can help reduce cancer-related fatigue in patients with head and neck cancer undergoing radiotherapy.
- Trial name
- NCT07809776
- Testing
- Tai Chi Intervention Group, Usual Care and Health Education
- Where
- China
- Volunteers
- 116 people
- Sponsor
- West China Hospital
Acute Aortic Syndrome, Aortic Dissection Type A
Protective Effect of Thymosin α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS).
- Trial name
- PANDA (NCT05339529)
- Testing
- Thymosin Alpha1, 28A-Glycine-28B-L-Arginine-28C-L-Glutamic Acid-28D-L-Alanine-28E-L-Proline-28F-L-Alanine-28G-L-Asparagine-, Blank control
- Where
- 15 sites in China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Head and Neck Squamous Cell Carcinoma
A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma
A Randomized, Non-comparative Phase II Clinical Trial of Becotatug Vedotin Combined with or without Immune Checkpoint Inhibitors (Penpulimab/Ivonescimab) in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck…
- Trial name
- NCT07381075
- Testing
- Becotatug Vedotin, Becotatug Vedotin Combined with Penpulimab, Becotatug Vedotin Combined with Ivonescimab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- West China Hospital
Tirzepatide, Frozen Embryo Transfer
Dual GIP/GLP-1 Receptor Agonist in Obese Women Before Frozen Embryo Transfer
To evaluate the efficacy and safety of Dual GIP/GLP-1 receptor agonist pretreatment on reproductive outcomes in obese women before frozen embryo transfer.
- Conditions
- Tirzepatide, Frozen Embryo Transfer, Obesity
- Trial name
- NCT07811895
- Testing
- Dual GIP/GLP-1 receptor agonist
- Where
- China
- Volunteers
- 1,510 people
- Sponsor
- RenJi Hospital
Duchenne Muscular Dystrophy
A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Single Intravenous Infusion of JWK007 in Patients With Duchenne Muscular Dystrophy (DMD)
This study is a single-center, single-arm, non-randomized, open-label, non-controlled, dose-escalation, prospective clinical trial designed to assess the safety, tolerability, and preliminary efficacy of JWK007 injection in…
- Trial name
- NCT06114056
- Testing
- JWK007 Single intravenous infusion administration
- Where
- China
- Volunteers
- 3 people
- Sponsor
- West China Hospital
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
PSMA PET/CT-Guided SBRT Plus Darolutamide in mHSPC
This is a multicenter, randomized, open-label phase 2 study for men with metastatic hormone-sensitive prostate cancer. About 254 participants will first receive 6 months of darolutamide plus androgen deprivation therapy.
- Trial name
- PSMA-DaroRT (NCT07649421)
- Testing
- Stereotactic Body Radiotherapy (SBRT), Darolutamide 600 mg twice daily, Androgen Deprivation Therapy (ADT)
- Where
- China
- Volunteers
- 254 people
- Sponsor
- West China Hospital
Central Nervous System Infections
Safety and Efficacy of Ventricular Irrigation for Ventriculitis
Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis.
- Trial name
- NCT06358209
- Testing
- Ventricular irrigation
- Where
- 35 sites in China
- Volunteers
- 310 people
- Sponsor
- RenJi Hospital
Solid Tumor, SGLT 2 Inhibitors
Safety and Efficacy of Canagliflozin in Patients With Locally Advanced or Advanced Solid Cancer
Revised version: Locally advanced or advanced solid tumors remain a major clinical challenge despite multimodal treatments, including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.
- Trial name
- SGLT2SOLID (NCT07703163)
- Testing
- Canagliflozin
- Where
- China
- Volunteers
- 15 people
- Sponsor
- West China Hospital
Radiation-Induced Skin Injury
Akkermansia Muciniphila (AKK) for Radiation-Induced Skin Injury
This study is a multicenter, open-label, Phase I single-arm clinical trial evaluating the safety and tolerability of a topical AKK probiotic preparation (Akkermansia muciniphila) for the prevention and treatment of…
- Trial name
- AKK-RIS (NCT07635277)
- Testing
- AKK Topical Preparation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Thrombus Aspiration in STEMI Patients With High Thrombus Burden
This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade ≥3) are included.
- Trial name
- NCT04212494
- Testing
- Thrombus aspiration, PCI Alone
- Where
- 50 sites in China
- Volunteers
- 3,838 people
- Sponsor
- Guangdong Provincial People's Hospital
Solid Tumor Cancer
Safety and Efficacy of an Arginine-Restricted Diet in Patients With Solid Tumors
This is a phase I single-arm clinical study conducted by West China Hospital of Sichuan University. The research duration is from March 2025 to March 2027, aiming to evaluate the safety and efficacy of arginine-restricted diet…
- Trial name
- NCT07038044
- Testing
- Arginine-restricted diet
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- West China Hospital
Non-Small Cell Lung Cancer (NSCLC), Rehabilitation
The Construction and Clinical Application of an Integrated Perioperative Management System for Lung Cancer Based on Wearable Devices and Intelligent Platforms
This study aims to develop and evaluate an integrated perioperative management system based on wearable devices and a digital rehabilitation platform for patients with non-small cell lung cancer (NSCLC) undergoing thoracic…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Rehabilitation, Thoracic Surgery, Perioperative Management
- Trial name
- NCT07310056
- Testing
- Wearable-Based Digital Perioperative Rehabilitation System, Standard Perioperative Rehabilitation Guidance
- Where
- China
- Volunteers
- 126 people
- Sponsor
- West China Hospital