Clinical trials: sponsored by Duke University
Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension
129Xe MRI Cardiopulmonary
The goal of this NIH-sponsored study is to characterize three biomarkers derived from 129Xe gas exchange MRI and to understand how they change in response to interventions.
- Conditions
- Interstitial Lung Disease, Chronic Thromboembolic Pulmonary Hypertension, Acute Pulmonary Embolism, Anemia
- Trial name
- NCT06038630
- Testing
- Hyperpolarized Xe129, Oxygen Administration
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Arthritis, Femoroacetabular Impingement
Conjoint Analysis of Patient Preferences in Joint Interventions
This study is an observational study to test and validate a questionnaire and statistical model used to determine patient preferences regarding treatment for any one of 11 musculoskeletal conditions: hip arthritis, knee…
- Conditions
- Arthritis, Femoroacetabular Impingement, Osteochondritis Dissecans, Hip Fractures
- Trial name
- NCT02664337
- Testing
- Decision tool, Standard treatment information
- Where
- United States
- Volunteers
- 2,310 people
- Sponsor
- Duke University
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Disease, Healthy Volunteers
The MURDOCK Study Registry and Biorepository Horizon 1.5
The MURDOCK Study Community Registry and Biorepository (Horizon 1.5) aims to create a large-scale community registry and biorepository that can be used as a vehicle for future health services, epidemiologic, clinical trials and…
- Trial name
- MURDOCK (NCT01708408)
- Testing
- Biomarker studies
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Parenting Intervention, Stress
Resilience Through Interventions for Successful Early Outcomes
Purpose: The purpose of this research is to determine the effects of Attachment and Biobehavioral Catch-up (ABC), an evidence-based parenting program, on stress biomarkers in children.
- Conditions
- Parenting Intervention, Stress, Caregiver Child Relationship, Child Behavior Problem
- Trial name
- RISE (NCT06669624)
- Testing
- Attachment and Biobehavioral Catch-up (ABC), Waitlist with 4-month delay, then ABC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Cancer
EBUS-TBNA vs Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing
This is a multi-center clinical trial evaluating the effect of transbronchial mediastinal cryobiopsy for its ability to improve the likelihood of obtaining tissue sufficient for molecular analysis.
- Trial name
- FROSTBITE-3 (NCT06105801)
- Testing
- Endobronchial ultrasound with transbronchial needle aspiration, Bronchoscopy, Cryobiopsy
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Gynecologic Surgical Procedures
Rectus Sheath Block for Analgesia After Gynecological Laparotomy
Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml…
- Trial name
- NCT06575699
- Testing
- Rectus sheath block, Thoracic Epidural Analgesia, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Trigeminal Neuralgia, Glossopharyngeal Neuralgia
Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia
The investigators will treat patients (targeting enrollment of n=20) who suffer from trigeminal or glossopharyngeal nerve pain in the context of painful small fiber neuropathy.
- Trial name
- NCT04158752
- Testing
- Galcanezumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Obesity, Childhood
Black Resilient Caregivers
To determine the feasibility of an intervention to promote the physical and socioemotional health of African American (AA) families.
- Trial name
- AARC (NCT06458790)
- Testing
- AARC
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Duke University
Rosacea, Erythematotelangiectatic
Metronidazole SC Penetrance With Moisturizers
Topical metronidazole is a widely used first line treatment for erythemotelangiectatic and inflammatory rosacea. Commonly, a moisturizer is also used to restore the skin barrier and reduce inflammation.
- Trial name
- NCT06434519
- Testing
- Metronidazole cream, Cetaphil moisturizer, CeraVe moisturizer
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Nutrition, Energy Requirement
Energy Needs and Nutritional Status of Adolescent Girls
The purpose of this study is to investigate the energy needs and nutritional status of adolescent girls in Abia State, Nigeria
- Trial name
- NARNia (NCT06601959)
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Diet Habit
Project humAn dieTary daTa rEtuRN
This study is designed to test the effects of diet data return on human dietary patterns. The investigators' working hypothesis is that returning diet data, collected via an empirical biomarker-based assessment method, will…
- Trial name
- PATTERN (NCT06266689)
- Testing
- Personalized Diet Information
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Duke University
Sepsis
Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up
The Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS) study is an effectiveness-implementation hybrid design.
- Trial name
- ASTROS (NCT05997420)
- Testing
- STAR Program, Usual Care
- Where
- United States
- Volunteers
- 1,820 people
- Sponsor
- Wake Forest University Health Sciences
ALS
Respiratory Muscle Training (RMT) in ALS
Twelve adults with ALS will participate in a study involving four 3-week cycles of progressive respiratory muscle training (RMT).
- Trial name
- NCT04224961
- Testing
- Respiratory Muscle Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
GastroEsophageal Cancer
Biobanking Upper Gastrointestinal Tumors to Evaluate Response (BURGER With BACON)
The goal of this observational study is to examine genetic changes that may contribute to immunotherapy resistance in gastroesophageal cancer.
- Trial name
- NCT06283238
- Testing
- Immune checkpoint inhibitor (ICI) or chemotherapy alone
- Where
- United States
- Sponsor
- Duke University
Asthma, Allergic, Asthma
IL13 Signaling in Allergic Asthma
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic…
- Conditions
- Asthma, Allergic, Asthma, Obesity
- Trial name
- NCT05478824
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Cardiovascular Diseases, Coronary Disease
ISCHEMIA-EXTEND (Extended Follow-up)
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Extended Follow-up (ISCHEMIA-EXTEND) is the long-term follow-up of randomized, surviving participants in ISCHEMIA.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Coronary Artery Disease, Heart Diseases
- Trial name
- NCT04894877
- Testing
- cardiac catheterization, coronary artery bypass graft surgery, percutaneous coronary intervention
- Volunteers
- 5,391 people
- Sponsor
- NYU Langone Health
Knee Dislocations, Multiple Ligament Knee Injuries
STaR Trial: Multiple Ligament Knee Injuries
The purpose of this study is to investigate effects of timing of surgery (early vs. delayed) and timing of post-operative rehabilitation (early vs.
- Trial name
- NCT03543098
- Testing
- Early Surgery, Delayed Surgery, Early Rehab
- Where
- United States
- Volunteers
- 690 people
- Sponsor
- University of Pittsburgh
Physician Rounds, Communication
Timing of Physician Rounds for Antepartum Patients
This study will include patients admitted to the Antepartum service at Duke University Hospital, many of whom are managing high-risk pregnancies that require extended hospital stays and frequent physician interactions.
- Trial name
- NCT07215507
- Testing
- Discovery Rounding, Standard Rounding
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Low Grade Glioma of Brain
Repeatability of Magnetic Resonance Imaging in Patients With IDH1 Mutant Glioma on Ivosidenib
The purpose of this study is to evaluate the repeatability of magnetic resonance imaging (MRI) in patients with isocitrate dehydrogenase 1 (IDH1) mutant (mIDH1) low-grade diffuse glioma [World Health Organization (WHO) grade 2]…
- Trial name
- NCT06648473
- Testing
- MRI Scan
- Where
- United States
- Sponsor
- Duke University
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