Clinical trials: not yet recruiting
Acute Myeloid Leukemia
Phase I Study Of PLM-102 In Patients With Relapsed And Refractory Acute Myeloid Leukemia
The goal of this clinical research study is to find the highest tolerable dose of PLM-102 that can be given to patients who have AML/MDS that is refractory and/or relapsed. The safety of PLM-102 will also be studied.
- Trial name
- NCT07549464
- Testing
- PLM-102
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Intracranial Aneurysm, Postoperative Pain
Effect of Bilateral Greater Occipital Nerve Block on Headache After Intracranial Aneurysm Coiling
Postoperative headache is a common complication following endovascular coil embolization of intracranial aneurysms and may increase analgesic requirements, impair patient comfort, and contribute to hemodynamic instability.
- Trial name
- NCT07910864
- Testing
- Ultrasound-Guided Bilateral Greater Occipital Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Konya City Hospital
Depression - Major Depressive Disorder, Generalised Anxiety Disorder
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
The goal of this clinical trial is to learn if an internet-based Unified Protocol (iUP) intervention is effective for treating depression and anxiety disorders in Hong Kong young adults aged 18-29 years.
- Conditions
- Depression - Major Depressive Disorder, Generalised Anxiety Disorder, Anxiety Disorder (Panic Disorder or GAD), Depressive and Anxiety Disorders
- Trial name
- NCT07908628
- Testing
- Internet-based Unified Protocol (iUP), Waitlist Control Group
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Non-Small Cell Lung Cancer
Risk-Adapted Segmental Esophagus-Sparing Radiotherapy for Definitive Non-Small Cell Lung Cancer
This is a multicenter, open-label, randomized, phase 3 superiority trial. The purpose is to find out whether a risk-adapted segmental esophagus-sparing radiotherapy plan is better than a standard radiotherapy plan at reducing…
- Trial name
- ES-SPARE (NCT07908732)
- Testing
- Risk-Adapted Segmental Esophagus-Sparing IMRT/VMAT, Standard IMRT/VMAT Without Active Esophageal Avoidance
- Volunteers
- 140 people
- Sponsor
- Ruijin Hospital
Anxiety
Pre-Examination Reflexology for Anxiety and Pain During Pelvic Examination
The purpose of this study is to evaluate whether a brief standardized reflexology session administered before the first pelvic examination reduces maternal state anxiety among term pregnant women admitted for induction of labor.
- Trial name
- NCT07910136
- Testing
- Pre-Examination Reflexology
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Goni Sintov
Solid Tumor
Comparing Radiotherapy Dose Strategies for Symptom Relief in Large Solid Tumors
This study will compare three ways of giving radiotherapy to relieve symptoms caused by a large solid tumor. Radiotherapy uses radiation to treat cancer.
- Trial name
- SCALE-LRT (NCT07908914)
- Testing
- Homogeneous External-Beam Radiotherapy, 20 Gy in Five Fractions, Homogeneous External-Beam Radiotherapy, 25 Gy in Five Fractions, LATTICE Radiotherapy, 20 Gy With a Simultaneous Integrated Boost to 66.7 Gy in Five Fractions
- Where
- Poland
- Volunteers
- 426 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Immune Related Disorder, Tissue Damage
Clonal Fetal Mesenchymal Stem Cells (cfMSCs) for the Control of Immune-related Disorders
The primary objectives are to evaluate the safety and efficacy of infusion of the third party fully-characterized clonally derived fetal MSCs (cfMSCs) for the control of severe symptoms associated with acute and chronic…
- Trial name
- NCT03123458
- Testing
- clonal fetal MSCs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Cervicogenic Headache
Comparative Effects of Dynamic Cupping and Facilitated Positional Release in Cervicogenic Headache
Cervicogenic headache (CGH) is a secondary headache disorder originating from structural and functional impairments of the cervical spine, accounting for approximately 15-20% of all chronic headaches worldwide.
- Trial name
- NCT07911254
- Testing
- Dynamic Cupping, Facilitated Positional Release technique
- Where
- Pakistan
- Volunteers
- 41 people
- Sponsor
- University of Management and Technology Lahore
Recovery of Function, Postoperative Period
Early Heart Rate Variability and Sleep and Quality of Recovery After Cesarean Delivery
This prospective single-center observational cohort study investigates whether objectively measured early postoperative heart rate variability (HRV) and sleep parameters are associated with patient-reported quality of recovery…
- Conditions
- Recovery of Function, Postoperative Period, Cesarean Section
- Trial name
- Otonom-CS (NCT07897331)
- Testing
- Wearable-derived heart rate variability and sleep monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Buca Seyfi Demirsoy State Hospital
Chronic Granulomatous Disease
Lentiviral Gene Therapy for CGD
This is a Phase I/II clinical trial of gene therapy for treating Chronic Granulomatous Disease using a high-safety, high-efficiency, self-inactivating lentiviral vector TYF to functionally correct the defective gene.
- Trial name
- NCT03645486
- Testing
- Infusion of lentiviral TYF-CGD-modified autologous stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Pancreatic Ductal Adenocarcinoma (PDAC)
A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer
The purpose of this study is to assess the safety, feasibility, and recommended dose of navlimetostat (BMS-986504) combined with mFOLFIRINOX before and after surgery in patients with localized pancreatic cancer with MTAP deletion.
- Trial name
- M-POP (NCT07905131)
- Testing
- Navlimetostat, mFOLFIRINOX Treatment Regimen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Daniel Nussbaum, M.D.
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bubpivacaine, Tramadol, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
B Cell Lymphoma (BCL)
Multi-CAR-T Cells Targeting B Cell Lymphomas
This study aims to evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting B cell surface molecules including CD19 and alternative CARTs as booster and…
- Trial name
- NCT04429438
- Testing
- 4SCAR19 and 4SCAR20/22/70/PSMA/13/79b/GD2
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm
Addressing Financial Hardship in AYA Cancer Survivors Through the Use of the New LIFT UP Intervention
This clinical trial addresses the financial hardship among adolescent and young adult (AYA) survivors using the new Lessening the Impact of Financial Toxicity (LIFT) UP intervention.
- Conditions
- Breast Ductal Carcinoma In Situ, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT07909525
- Testing
- Best Practice, Educational Intervention, Informational Intervention
- Volunteers
- 448 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Obesity (Disorder), Inflammation
Effects of Taurine Supplementation and Morning or Evening High-intensity Exercise on Circadian Clock Genes and Inflammatory Parameters in Adult Women With Obesity
The goal of this clinical trial is to evaluate whether taurine supplementation, alone or combined with high-intensity interval training (HIIT) performed in morning or evening, affects circadian clock gene expression and…
- Trial name
- NCT07910747
- Testing
- Taurine supplementation, High-intensity interval training (HIIT)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Tract Infection
HAIQU (Hospital AIr QUality)
The purpose of this research is to assess whether integration of an aerosol biosensor and air quality risk assessment software that integrates into a building management system will improve indoor air quality metrics in hospital…
- Trial name
- HAIQU (NCT07670117)
- Testing
- Self-swab test
- Where
- 3 sites in United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Inflammatory Bowel Diseases Weight Changes
Weight and BMI Patterns in Biological Based IBD Patients and Its Finacial Impact
Primary Objective To determine the pattern of weight and body mass index (BMI) changes in biologic-treated patients with inflammatory bowel disease (IBD).
- Trial name
- obesity/IFX (NCT07495800)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Healthy Aging, Cognition
Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study
This pilot study aims to investigate the effects of a single oral dose of cannabidiol (CBD) on memory and attention in healthy adults aged 60 to 70 years.
- Trial name
- CBD-MAP (NCT07910292)
- Testing
- Cannabidiol (CBD)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Osteoarthritis, Knee
PPV-06 Vaccine in Inflammatory Knee Osteoarthritis
PPV-06 targets interleukin-6, a key molecule implicated in many inflammatory diseases such osteoarthritis. PPV-06 is used to induce the production of antibodies directed against IL-6.
- Trial name
- NCT06605963
- Testing
- PPV-06
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Peptinov SAS
Mesothelin-Positive Advanced Solid Tumors With Peritoneal Metastasis
A Study of Mesothelin-Targeted CAR-Mix Cells in Patients With Advanced Solid Tumors
An exploratory, open-label, single-arm, dose-escalation clinical study evaluating the safety, tolerability, pharmacokinetics/pharmacodynamics, and preliminary antitumor activity of intraperitoneally administered SY001…
- Trial name
- NCT07909434
- Testing
- SY001
- Volunteers
- 10 people
- Sponsor
- Zhejiang University
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