Clinical trials: sponsored by Duke University
Cancer, Breast Cancer
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult (AYA) cancer survivors manage symptoms and engage in recommended…
- Conditions
- Cancer, Breast Cancer, Colorectal Cancer, Sarcoma
- Trial name
- AYA STEPS (NCT06371768)
- Testing
- AYA Educational Information, AYA STEPS
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Duke University
Chronic Pain
The Thrive Study: Improving Multimodal Physical Function in Adults With Heterogenous Chronic Pain
The investigators aim to conduct a randomized controlled trial to test the feasibility of a mind-body walking program compared to a health education program for individuals with chronic musculoskeletal pain.
- Trial name
- NCT05700383
- Testing
- GetActive-Fitbit, Healthy Living for Pain
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bronchopulmonary Dysplasia of Newborn
Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia
This is a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study of sildenafil in premature infants (inpatient in Neonatal Intensive Care Units (NICUs)) with severe bronchopulmonary…
- Trial name
- SILDI-SAFE (NCT04447989)
- Testing
- Sildenafil
- Where
- 25 sites in United States
- Volunteers
- 125 people
- Sponsor
- Christoph Hornik
Vasculitis, Behcet's Disease
Vasculitis Pregnancy Registry
The purpose of this study is to learn about the experience of women with vasculitis who become pregnant. In particular, the study will consist of several online surveys to assess 1.
- Conditions
- Vasculitis, Behcet's Disease, CNS Vasculitis, Cryoglobulinemic Vasculitis
- Trial name
- V-PREG (NCT02593565)
- Testing
- Online questionnaires
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
Juvenile Idiopathic Arthritis
Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)
This is a research study to test whether a once-weekly injection of abatacept will prevent the progression of Juvenile Idiopathic Arthritis (JIA) to a more severe form.
- Trial name
- Limit-JIA (NCT03841357)
- Testing
- Abatacept Injection, Usual Care
- Where
- 19 sites in United States
- Volunteers
- 121 people
- Sponsor
- Duke University
Multiple Myeloma
Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65
In this research study, we are looking to explore the drug combination, lenalidomide, bortezomib and dexamethasone alone or when combined with autologous stem cell transplantation to see what side effects it may have and how well…
- Trial name
- DFCI 10-106 (NCT01208662)
- Testing
- Lenalidomide, Bortezomib, Dexamethasone
- Where
- 46 sites in United States
- Volunteers
- 729 people
- Sponsor
- Paul Richardson, MD
Cardiovascular Diseases
Highly Processed Foods and Vascular Health
Age is the primary risk factor for cardiovascular disease (CVD) and age-related vascular dysfunction is considered the key process linking the two.
- Trial name
- NCT05628350
- Testing
- No UPF controlled diet, High UPF controlled diet
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Knee Injuries, Knee Osteoarthritis
Walking Gait Biomechanics Following Knee Joint Effusion
The purpose of this study is to determine the sensitivity of a wearable sensor to detect changes in knee joint loading using an experimental knee joint effusion as a model for a common clinical physiological alteration in joint…
- Trial name
- NCT03805464
- Testing
- Knee Joint Effusion
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
- Trial name
- NCT06404086
- Testing
- Modafinil, Solriamfetol, Melatonin
- Where
- 47 sites in United States
- Volunteers
- 830 people
- Sponsor
- Duke University
Chronic Graft Versus Host Disease
Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
This is an open-label phase I study of fostamatinib in combination with ruxolitinib for the treatment of chronic GvHD with a suboptimal response to corticosteroids.
- Trial name
- NCT06233110
- Testing
- Fostamatinib, Ruxolitinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stefanie Sarantopoulos, MD, PhD.
Chronic Pain
Tailored Non-Pharmacotherapy Services for Chronic Pain
The RESOLVE study is a multicenter comparative effectiveness trial of two cognitive behavioral therapy-based chronic pain (CBT-CP) treatments delivered via telehealth modalities: 1) online program and 2) live, health coach-led…
- Trial name
- RESOLVE (NCT04523714)
- Testing
- Online CBT-CP based program, Virtual health coach-led CBT-CP based program
- Where
- 4 sites in United States
- Volunteers
- 2,333 people
- Sponsor
- Kaiser Permanente
Asthma
Terbutaline Sulfate in Adults With Asthma
The overall aim in Part 1 is to compare the pharmacokinetic (PK)/pharmacodynamics (PD) relationship in intravenous (IV) versus subcutaneous (SQ) terbutaline sulfate to identify the optimal IV dosing range for use in Part 2.
- Trial name
- TBS02 (NCT04973345)
- Testing
- Terbutaline
- Where
- 2 sites in United States
- Sponsor
- Kanecia Obie Zimmerman
Stroke, Ischemic
DELTA (Detecting and Predicting Atrial Fibrillation in Post-Stroke Patients)
Atrial Fibrillation (AF) is an abnormal heart rhythm. Because AF is often asymptomatic, it often remains undiagnosed in the early stages. Anticoagulant therapy greatly reduces the risks of stroke in patients diagnosed with AF.
- Trial name
- NCT05795842
- Testing
- wearable wristband model, Samsung Galaxy Watch 6, Standard of care extended ECG monitoring
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Emory University
Advanced Cancer
Coping Together: Couple-based Interventions for Cancer
The objective of the proposed study is to evaluate the Couple Communication Skills Training (CCST) intervention in 250 patients with advanced cancer and their spouses/intimate partners.
- Trial name
- CCST2 (NCT04590885)
- Testing
- Couple Communication Skills Training, Healthy Lifestyle Information
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Duke University
Infertility, Psychological Distress
ACT for Infertility: Case Series
In the United States, around 19% of reproductive-aged couples suffer from infertility. The psychological distress associated with infertility is well-established; those diagnosed commonly experience depression and anxiety…
- Conditions
- Infertility, Psychological Distress, Acceptance and Commitment Therapy, Psychological Flexibility
- Trial name
- NCT06388044
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Glioblastoma
Key Longitudinal Associations With Risk and Glioblastoma Outcomes
The goal of this observational study is to find out what factors affect the health and risks in adults with glioblastoma (GBM), a grade 4 brain cancer.
- Trial name
- Key LARGO (NCT06625684)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Hematologic Malignancy
HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT
This study is a single-center, non-randomized, single-arm pilot trial of omidubicel hematopoietic stem cell transplantation (HCT) for hematologic malignancies with myeloablative conditioning chemotherapy of physician's choice…
- Trial name
- NCT06731504
- Testing
- Abatacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Interstitial Lung Disease
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function.
- Trial name
- NCT01280994
- Testing
- Hyperpolarized 129Xenon Gas
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Bastiaan Driehuys
Accidental Falls/Prevention and Control, Osteoporosis
Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications
The goal of this clinical trial is to compare three care models for optimizing medications and preventing falls with broken bones in patients receiving rehabilitation after a hospitalization for a broken bone.
- Trial name
- PRISM (NCT06304428)
- Testing
- Deprescribing Care Model, Bone Health Service Model, Injury Prevention Service Model
- Where
- 2 sites in United States
- Volunteers
- 3,780 people
- Sponsor
- Duke University
Pediatric Obesity, Food Insecurity
Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health
Food insecurity is associated with obesity in children, and childhood obesity leads to long term health consequences. While existing research shows that food benefit programs reduce food insecurity, little is known about the…
- Conditions
- Pediatric Obesity, Food Insecurity, Nutrition, Healthy, Nutrition Poor
- Trial name
- NOURISH (NCT06116422)
- Testing
- Grocery intervention - unrestricted, Grocery intervention - restricted
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Duke University
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