Clinical trials: sponsored by Duke University
Genetic Disease, Inborn Errors of Metabolism
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders
The goal of this study is to identify and characterize novel non-coding and splicing variants that may contribute to genetic disorders.
- Conditions
- Genetic Disease, Inborn Errors of Metabolism, Glycogen Storage Disease, Lysosomal Storage Diseases
- Trial name
- NCT04399694
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Parkinson Disease
Cognitive Disparities in Parkinson's Disease
This study will investigate disparities in neurocognitive impairment (NCI) among Hispanics/Latinos/as/x (henceforth Hispanics) living in the US-Mexico borderland of California or in North Carolina with Parkinson's Disease (PD)…
- Trial name
- NCT07262658
- Testing
- Will examine how Cardiovascular Disease risk, PD severity and social determinants impact neurocognitive impairment in Hispanics vs non-Hispanics Whites
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Depression
Latino Teen Depression Treatment Study
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA)…
- Trial name
- NCT05499182
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
Delirium in Old Age
REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant
This research study will evaluate the effectiveness of postoperative administration of a drug called suvorexant, to improve postoperative sleep and decrease the severity of delirium (serious confusion) in adults 65 years and…
- Trial name
- REPOSE (NCT05733286)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Duke University
Insulin Sensitivity, 24-hour Glucose Control
Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis
Advancing age is associated with gut dysbiosis, low-grade chronic inflammation, progressive insulin resistance, and increased risk of type 2 diabetes (T2D).
- Trial name
- NCT05358171
- Testing
- HIgh UPF controlled diet, No UPF controlled diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cirrhosis, Cirrhosis, Liver
Liver Cirrhosis Network Cohort Study
Liver Cirrhosis Network (LCN) Cohort Study is an observational study designed to identify risk factors and develop prediction models for risk of decompensation in adults with liver cirrhosis.
- Conditions
- Cirrhosis, Cirrhosis, Liver, Cirrhosis Early, Cirrhosis Due to Hepatitis B
- Trial name
- LCN-C (NCT05740358)
- Where
- 14 sites in United States
- Volunteers
- 1,222 people
- Sponsor
- Northwestern University
Cervical Cancer, HPV Infection
Pocket Colposcopy Using CARE Algorithm
The Pocket colposcope has 510k FDA clearance and has been successfully used in ~2500 unique patients globally in Duke and non-Duke protocols to date.
- Trial name
- NCT06458062
- Testing
- Pocket Colposcope
- Where
- Kenya
- Volunteers
- 1,079 people
- Sponsor
- Duke University
Intensive Care Unit ICU
Virtual Reality Use for ICU Mobility
The purpose of this study is to explore if Virtual Reality (VR) helps patients in the Intensive Care Unit (ICU) move more and feel better.
- Trial name
- GAMERS (NCT07234201)
- Testing
- Nurse driven virtual reality mobility session
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Chronic Pain, Tobacco Use
Opioids, Low Nicotine Cigarettes, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain…
- Conditions
- Chronic Pain, Tobacco Use, Opioid Substitution Treatment
- Trial name
- NCT06747871
- Testing
- Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Autism or Autistic Traits
Autism Caregiver Coaching in Africa
Around the world there is a growing need to develop early intervention services in local communities that support a better quality of life for all autistic people.
- Trial name
- ACACIA (NCT05551728)
- Testing
- ESDM-informed caregiver coaching
- Where
- South Africa
- Volunteers
- 320 people
- Sponsor
- Duke University
Opioid Use Disorder
OUD (Opioid Use Disorder) Target Trial
In this research study the investigators will work with 80-participants with opioid use disorder who are starting treatment with the medication buprenorphine and are trying to quit using opioids.
- Trial name
- NCT06585709
- Testing
- Active repetitive Transcranial Magnetic Stimulation (rTMS), High Ventral Striatal Reactivity, Low Ventral Striatal Reactivity
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Systemic Lupus Erythematosus, Cutaneous Lupus
Duke Lupus Registry
Lupus is a systemic autoimmune disease that can present with many varied symptoms, including joint pain, fevers, kidney disease, and rashes. Lupus can affect anyone, but it is most common in younger women.
- Trial name
- NCT00512694
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Autoimmune Diseases, Pregnancy Related
Maternal Autoimmune Disease Research Alliance (MADRA) Registry
This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and…
- Conditions
- Autoimmune Diseases, Pregnancy Related, Systemic Lupus Erythematosus, Cutaneous Lupus
- Trial name
- MADRA (NCT03276923)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Primary Progressive Multiple Sclerosis
Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis
This study is a prospective Phase 1a open-label single- center trial. It will assess the safety of intrathecal administration of DUOC-01 cells to adults with Primary Progressive Multiple Sclerosis (PPMS).
- Trial name
- DUOC for MS (NCT04943289)
- Testing
- DUOC-01
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Joanne Kurtzberg, MD
Shoulder Disease, Rotator Cuff Tear Arthropathy
Sling vs No Sling After Reverse Total Shoulder Arthroplasty
This study involves patients who will be undergoing a reverse total shoulder replacement at Duke University. 100 eligible will be randomly assigned into one of two groups, a sling or no sling group.
- Conditions
- Shoulder Disease, Rotator Cuff Tear Arthropathy, Shoulder Osteoarthritis
- Trial name
- NCT06092996
- Testing
- Time of Sling Use
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Pediatric ALL
Pharmacokinetics of Drugs Administered to Children
This is a prospective study of children <21 years of age with the goal of characterizing the PK of drugs administered per standard of care as prescribed by the treating caregiver.
- Trial name
- NCT03481881
- Testing
- Standard of care drug
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Glycogen Storage Disease, GSD Type 0A
Rare Glycogen Storage Diseases Natural History Study
The purpose of this study is to collect and study key medical data about several ultra-rare GSDs (Glycogen Storage Diseases) including, but not limited to, GSD types 0a, 0b, VII, X, XII, XIII, XV, PRKAG2 syndrome and Danon…
- Conditions
- Glycogen Storage Disease, GSD Type 0A, GSD Type 0B, GSD VII
- Trial name
- NCT06795152
- Testing
- No intervention
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Cleft Lip, Cleft Palate
Allied Cleft & Craniofacial Quality-Improvement and Research Network (ACCQUIREnet)
The Allied Cleft \& Craniofacial Quality-Improvement and Research Network (ACCQUIREnet) is a group of multidisciplinary cleft teams that have implemented a system for prospective collection of outcomes data, based on the ICHOM…
- Conditions
- Cleft Lip, Cleft Palate, Cleft Lip and Palate
- Trial name
- ACCQUIREnet (NCT02702869)
- Testing
- cleft lip repair, cleft palate repair, oronasal fistula repair
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Cardiac Sarcoidosis
Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression
This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT.
- Trial name
- NCT06510894
- Testing
- Sotagliflozin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Transplant;Failure,Kidney, Transplant; Failure, Liver
Abdominal Wall Transplant
The purpose of this protocol is to determine the safety and efficacy of abdominal wall transplantation as a treatment for the reconstruction of abdominal wall defects.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Liver, Transplant; Failure, Bowel, Abdominal Wall Defect
- Trial name
- NCT03310905
- Testing
- Abdominal Wall Transplant with another solid organ transplant, Abdominal Wall Transplant alone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
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