Clinical trials: not yet recruiting
Disease Related Malnutrition
Tolerance and Acceptability of an Oral Nutrition Supplement
The goal of this study is to learn whether a new oral nutritional supplement is acceptable to adults who are malnourished, or at risk of malnutrition, and need nutritional support.
- Trial name
- NCT07904715
- Testing
- Oral nutritional supplementation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Aymes International Limited
Healthy
Meditation and Yogic Breathing-driven Modulation of Neurofluid Coupling and Brain Clearance
This study will examine whether meditation and yogic breathing can alter brain fluid movement and waste clearance in healthy adults.
- Trial name
- SPANDHA (NCT07903688)
- Testing
- Nadi Shuddhi, Shoonya Meditation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Hypertension
Effects of Smartphone Use and Television Viewing on Standardized BP Measurement: The SCREENS-BP Study
The SCREENS-BP study is a randomized crossover study evaluating the effects of smartphone use and television viewing on blood pressure (BP) measurements in 96 adults.
- Trial name
- SCREENS-BP (NCT07903779)
- Testing
- Standardized office blood pressure measurements
- Where
- 2 sites in Australia, Canada
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Breast Cancer (Advanced/Metastatic)
Study of Trastuzumab Deruxtecan in Combination With Stereotactic Radiosurgery in Patients With HER2-Positive Metastatic Breast Cancer and First Diagnosis of Brain Metastases (HERBRAIN)
This is a Phase II, single-arm, Bayesian adaptive trial. The study employs a two-stage design with an interim analysis after 30 evaluable patients and a maximum enrolment of 60 patients.
- Trial name
- HERBRAIN (NCT07905313)
- Testing
- SRS/fSRT+T-Dxd
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Acute Stroke, Upper Limb Motor Deficit
Effect of Early Tendon Vibrations on Upper Limb Motor Recovery After a Stroke
Strokes often induce a motor deficit. The resulting immobilization is in itself an aggravation factor since it worsens the motor deficit induced by the stroke itself.
- Trial name
- VIBRASTROKE (NCT07905625)
- Testing
- TVS rehabilitation sessions
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Octogenarian Patients With Non-metastatic Resectable Colorectal Cancer
SGA-OCRC: Prediction of 90-Day Major Adverse Postoperative Outcomes in Octogenarians With Resectable Colorectal Cancer
Octogenarian patients with colorectal cancer are a growing population with substantial heterogeneity in frailty, functional reserve, nutritional status, and comorbidity.
- Trial name
- NCT07903129
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mycoplasma Genitalium Infection, Urethritis
Omadacycline for Treatment Refractory Mycoplasma Genitalium Urethritis
Urethritis from Mycoplasma genitalium is difficult to treat and often does not respond to first line therapy. In this case series study, individuals who have failed first line therapy will receive omadacycline (provided by…
- Trial name
- NCT07853742
- Testing
- Omadacycline Oral Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Montefiore Medical Center
Locally Advanced Rectal Cancer, Rectal Adenocarcinoma
Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal Cancer
This prospective national multicentre feasibility study evaluates dose-escalated short-course proton radiotherapy followed by total neoadjuvant chemotherapy in patients with primary high-risk locally advanced rectal…
- Trial name
- PROSPECT-WW (NCT07903883)
- Testing
- Intensity modulated proton therapy
- Where
- 8 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Aarhus
Lipid Profile, Blood Glucose
Prickly Pear Pulp Powder Along With an Anti-inflammatory Diet in Patients Having Liver Fibrosis
This RCT will evaluate the 12-week therapeutic effects of prickly pear pulp powder lozenges (0.5, 1.0, and 1.5 g/day) combined with an anti-inflammatory diet in adults with liver fibrosis (F1-F3).
- Conditions
- Lipid Profile, Blood Glucose, Liver Enzymes
- Trial name
- NCT07903103
- Testing
- Experimental
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Juvenile Idiopathic Arthritis (JIA)
Withdrawal Versus Continued TNF Inhibitor Monotherapy Treatment in Children With Inactive Juvenile Idiopathic Arthritis
The goal of this clinical trial is to learn whether children and adolescents with juvenile idiopathic arthritis (JIA) who have had inactive disease for a long time can safely discontinue treatment with a tumour necrosis factor…
- Trial name
- The Treat-JIA (NCT07904780)
- Testing
- Adalimumab, Etanercept, Golimumab
- Where
- 3 sites in Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Breast Cancer, Hormone-receptor-positive Breast Cancer
A Phase 1/1b Study of PRT13722 in Participants With Advanced HR+/HER2- Breast Cancer
This first-in-human, open-label, multicenter study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of PRT13722, an oral KAT6A protein degrader, in adults with locally…
- Conditions
- Breast Cancer, Hormone-receptor-positive Breast Cancer, HER2-negative Breast Cancer, HR-positive Breast Cancer
- Trial name
- NCT07905001
- Testing
- PRT13722, Fulvestrant, Abemaciclib
- Volunteers
- 242 people
- Sponsor
- Prelude Therapeutics Incorporated
Postoperative Pain, Acute Pain
Two Bupivacaine Concentrations for Recto-Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy
Pain after laparoscopic cholecystectomy remains clinically relevant, and current recommendations favour multimodal, opioid-sparing analgesia including regional techniques.
- Conditions
- Postoperative Pain, Acute Pain, Cholelithiasis, Anesthesia
- Trial name
- NCT07841951
- Testing
- Bupivacaine 0.25% - recto-intercostal fascial plane block, Bupivacaine 0.125% - recto-intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Body Hygiene Status in Bedbound Individuals
Development of a Body Hygiene Assessment Scale for Bedbound Individuals
This study aims to develop a valid and reliable assessment scale for evaluating body hygiene status in bedbound individuals. Maintaining body hygiene is an essential component of nursing care, particularly for patients who depend…
- Trial name
- NCT07905794
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Apical Periodontitis
Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment
This study will compare three methods of activating the final irrigation solution in reducing living bacteria inside the root canals of teeth that require root canal retreatment because of apical periodontitis, an inflammatory…
- Trial name
- NCT07903285
- Testing
- Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Inonu University
Cardiac Surgery
Randomized Evaluation of Operating Room Extubation After Cardiac Surgery
We are studying whether waking patients up and removing the breathing tube (also known as "extubation") in the operating room after cardiac surgery improves postoperative recovery without causing harm.
- Trial name
- NCT07757880
- Testing
- OR extubation, ICU extubation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Physial Disabilities
Examining the Health Impact of and Promoting Sitting Light Volleyball in the Greater Bay Area
The present study builds on the promising result of our SLVB pilot study with the aim to extend the works' impact by investigating the effectiveness of a SLVB intervention on the physical and psychological health outcomes in…
- Trial name
- NCT07164508
- Testing
- Sitting Light Volleyball Intervention, Group Seated Dance Intervention
- Where
- Hong Kong
- Volunteers
- 225 people
- Sponsor
- Education University of Hong Kong
Glomerulopathy, C3G
Pilot STUDY to Monitor Ex-vivo the Biological Effects of the C3 Inhibitor, PEGCETACOPLAN, on Activation of Complement in Fluid Phase and on Podocytes in Patients With C3G and Primary IC-MPGN
This is a prospective, multicenter, non-interventional, observational pharmacological real-world study to characterize longitudinal changes in ex vivo biomarkers of complement activation in patients with C3G and primary IC-MPGN…
- Conditions
- Glomerulopathy, C3G, Membranoproliferative Glomerulonephritis (MPGN)
- Trial name
- COMPASS (NCT07904338)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
HR+/HER2+ Breast Cancer, Metastatic Breast Cancer
Targeting Aurora A Kinase to Overcome Treatment Resistance in Advanced HR+/HER2+ Breast Cancer
The goal of this clinical trial is to learn if alisertib in addition to usual care works to treat HR+/HER2+ breast cancer. The main questions it aims to answer are: Does alisertib stop the communication between HR and HER2? Are…
- Trial name
- NCT07706179
- Testing
- Alisertib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Blood Pressure Measurement
Equivalence of Systolic Blood Pressure Measurements Between Fowler and Seated Positions
Blood pressure is an important part of checking heart health. Blood pressure is usually measured while sitting, but in everyday medical care it is sometimes measured in other positions, such as the Fowler position, where the…
- Trial name
- POSE-SBP (NCT07878858)
- Testing
- blood pressure measurement in the semi-recumbent position, Standard BP measurement
- Where
- 2 sites in Romania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Primary Ovarian Insufficiency
Oral GDC-0077 in Premature Ovarian Insufficiency
This is a single-center, single-arm, exploratory clinical trial evaluating the safety and potential effect of oral GDC-0077 on ovarian function in women with premature ovarian insufficiency (POI).
- Trial name
- NCT07904208
- Testing
- GDC-0077
- Volunteers
- 12 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
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