Clinical trials: sponsored by Duke University
Breast Cancer
mHealth Behavioral Cancer Pain Intervention for Medically Underserved Patients
The efficacy of a mobile health (mHealth) behavioral cancer pain intervention designed to decrease pain and disability for breast cancer patients in medically underserved areas has not been investigated.
- Trial name
- ICAN-NC (NCT04175639)
- Testing
- Mobile Health Pain Coping Skills Training (mPCST)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Resilience, Aging
Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2
The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).
- Trial name
- PRIME-Knee (NCT04235309)
- Where
- 3 sites in United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Cardiac Rehabilitation, Heart Disease
Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation
The SPARC study will measure physical activity and functional fitness during cardiac rehabilitation, right after completion of cardiac rehabilitation, and 6 months later.
- Trial name
- SPARC (NCT07214350)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Cognitive Decline, Blood Pressure
Preventing Cognitive Decline by Reducing BP Target Trial
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial…
- Conditions
- Cognitive Decline, Blood Pressure, Hypertension
- Trial name
- PCOT (NCT05106036)
- Testing
- Clinical Support Decision Tool
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Long COVID, Long Covid19
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Trial name
- RECOVER-VITAL (NCT05595369)
- Testing
- Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing
- Where
- 69 sites in United States, Puerto Rico
- Volunteers
- 963 people
- Sponsor
- Kanecia Obie Zimmerman
New Persistent Daily Headache
NDPH Biomarker Study in Children and Adolescents
This study will recruit pediatric patients with NDPH (New Daily Persistent Headache), characterize their headache in a standard manner, and treat the NDPH with standard medications used for treatment of headaches in this…
- Trial name
- NCT06018025
- Testing
- CGRP antibody
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
You and Me Healthy
The You and Me Healthy Registry provides a resource for collecting information on people currently living in the United States. The overall goal of the Registry is to create and engage a community of people who may be eligible…
- Trial name
- YMH (NCT05589376)
- Where
- 3 sites in United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Axial Spondyloarthritis
Clinical Trial of TCM Collaborative Care Model in Axial Spondyloarthritis
A pragmatic, prospective, randomized controlled trial will be conducted in patients with axial spondyloarthritis who are NSAID inadequate responders.
- Trial name
- AcuSpA (NCT03420404)
- Testing
- TCM physician involved collaborative care model (TCMCMC)
- Where
- Singapore
- Volunteers
- 140 people
- Sponsor
- Singapore General Hospital
Hematopoietic Steam Cell Transplantation (HCT)
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients
This is a research study to develop and test a novel protocol to reduce physical and psychological vulnerabilities that contribute to treatment intolerance and treatment-related morbidity and mortality among hematopoietic stem…
- Trial name
- NCT04423939
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
End Stage Kidney Disease
Symptom Monitoring in Hemodialysis
The SMaRRT-HD trial is a cluster randomized trial of symptom monitoring with supported clinician follow-up using the SMaRRT-HD electronic patient reported outcome measure (ePROM) system versus Usual Care.
- Trial name
- SMaRRT-HD (NCT05738330)
- Testing
- Symptom Monitoring on Renal Replacement Therapy - Hemodialysis (SMaRRT-HD), Usual Care
- Where
- United States
- Volunteers
- 2,400 people
- Sponsor
- University of Pennsylvania
Severe Asthma
Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma.
- Trial name
- NCT07139899
- Testing
- Hyperpolarized Xenon 129
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Bastiaan Driehuys
Tobacco Use, Chronic Pain
Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain.
- Trial name
- PRISM02 (NCT06983678)
- Testing
- Smoking as usual fMRI session, Abstinent fMRI session
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Duke University
Hematologic Malignancies, Inborn Errors of Metabolism Disorders
Expanded Access to T-cell Depleted Haplo-Identical Stem Cells for Patients Receiving Haplo-Identical and Unrelated Cord Blood Transplants
The objective of this study is to make T-cell depleted stem cells from a family member who is a half match (haplo-identical) available on an expanded access basis to patients receiving one or two unrelated cord blood transplants…
- Conditions
- Hematologic Malignancies, Inborn Errors of Metabolism Disorders, Immune Deficiencies
- Trial name
- NCT01881334
- Testing
- CliniMACS CD34 Reagent System
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Single Level Spinal Fusion, Discetomy
Integration of Mindfulness and Acupuncture After Spine Surgery
The Integration of Mindfulness and Acupuncture for individuals undergoing Spine Surgery (I-MASS) is a novel combination of integrative treatments to improve post-surgical recovery.
- Conditions
- Single Level Spinal Fusion, Discetomy, Laminectomy
- Trial name
- I-MASS (NCT06429072)
- Testing
- Mindfulness training, Acupuncture, Enhanced education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Cleft Lip and Nose, Nasal Obstruction
Computational Modeling of Cleft Lip Nasal Deformity and Assessment of Nasal Function and Treatment Outcomes
The purpose of this study is to use computers to simulate airflow in 3D construction of your nasal cavity generated from cone beam CT images.
- Trial name
- NCT04150783
- Testing
- Surgical repair for nasal obstruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Opioid Use, Pain, Postoperative
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
The overall goal of this research is to improve perioperative pain treatment, decrease post-operative opioid consumption, diminish opioid related side effects, and reduce postop opioid prescribing (and hence opportunity for…
- Trial name
- OSPREy (NCT03726268)
- Testing
- Methadone, Fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 907 people
- Sponsor
- Duke University
Caregivers, Technology
CLARE Mobile App for Caregiver Training and Support
This pilot study will investigate the feasibility of using a digital health application, Communication, Learning, Advocacy, Resources and Expertise (CLARE), in training and support of family and friends (i.e., caregivers) of…
- Trial name
- NCT05877586
- Testing
- CLARE app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Covid19
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19.
- Trial name
- NCT06042855
- Testing
- Metformin
- Where
- 110 sites in United States
- Volunteers
- 3,214 people
- Sponsor
- Susanna Naggie, MD
Chronic Neck Pain
Specific and Shared Mechanisms Associated With Treatment for Chronic Neck Pain
It is expected that different physical therapy treatments influence outcomes in many different ways. Each treatment is assumed to have a "specific" treatment mechanism, which explains how that specific treatment works.
- Trial name
- SS-MECH (NCT05940012)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Duke University
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