Clinical trials: sponsored by Changhai Hospital
Esophageal Squamous Carcinoma
Neoadjuvant Therapy With Iparomlimab and Tuvonralimab, Lenvatinib and Chemotherapy in Resectable ESCC
This is a single-arm, exploratory clinical study.
- Trial name
- NCT07490002
- Testing
- Iparomlimab and Tuvonralimab+Lenvatinib + Cisplatin/Carboplatin + Nab-paclitaxel
- Volunteers
- 33 people
- Sponsor
- Changhai Hospital
End Stage Renal Disease
Effects of Hemodialysis Plus Hemoperfusion in Maintenance Hemodialysis Patients: A Clinical Study
This multi-center, open-label, randomized, parallel controlled trial aims to investigate the efficacy of hemoperfusion (HP) in combination with hemodialysis (HD) by assessing blood β2-microglobulin (β2-MG), parathyroid hormone…
- Trial name
- NCT05639010
- Testing
- regular hemodialysis, hemoperfusion combined with hemodialysis
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Changhai Hospital
Gastrointestinal Bleeding
Capsule Endoscopy in GI Bleeding: A Retrospective Study
The goal of this observational study is to evaluate the diagnostic value and safety of capsule endoscopy in patients with gastrointestinal bleeding.
- Trial name
- NCT07481591
- Testing
- capsule endoscopy
- Volunteers
- 350 people
- Sponsor
- Changhai Hospital
Renal Colic, Acupuncture, Ear
Ear Pressure Points Plus Pain Meds for Faster Kidney Stone Pain Relief
Title: Can Ear Acupressure Help Relieve Kidney Stone Pain Faster When Combined with Painkillers? Purpose: This study tests whether adding ear acupressure to standard painkillers (NSAIDs) helps adults with kidney stone pain feel…
- Trial name
- NCT06978816
- Testing
- Non-Steroidal anti-inflammatory drugs (NSAIDS), Auricular Acupoint Embedding
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Gao Xiaofeng
Upper Gastrointestinal Cancer, Upper Gastrointestinal Precancerous Lesions
Establishment of Image Database for Early Upper Gastrointestinal Cancer, Precancerous Lesions, and Precancerous Conditions
The study is designed to collect magnetically-controlled capsule endoscopy (MCE) images, esophagogastroduodenoscopy (EGD) images, CT images, and histopathology results to establish a database for early upper gastrointestinal…
- Conditions
- Upper Gastrointestinal Cancer, Upper Gastrointestinal Precancerous Lesions, Upper Gastrointestinal Precancerous Conditions
- Trial name
- NCT07462247
- Testing
- magnetically-controlled capsule endoscopy, esophagogastroduodenoscopy, CT scan, ESD, biopsy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation (AF)
Research on Post-Stroke Anticoagulation Strategies for Atrial Fibrillation Based on Left Atrial Appendage Flow Velocity Measured by Intracardiac Echocardiography (ICE)
1. Study Purpose The primary aim of this research was to systematically describe and characterize a novel, thrombus-mimicking artifact observed during Intracardiac Echocardiography (ICE), termed the "Floating Lotus" sign.
- Trial name
- NCT07439731
- Testing
- Intracardiac Echocardiography (ICE) for Differential Diagnosis
- Where
- 2 sites in China
- Volunteers
- 172 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Diagnose Disease
AI-Powered Precision Decision-Making for Pancreatic Diseases
This multicenter clinical trial evaluates an artificial intelligence (AI) system designed to assist in the diagnosis and management of pancreatic diseases.
- Conditions
- Pancreatic Cancer, Diagnose Disease, IPMN, Pancreatic, Pancreatic Cystic Lesions
- Trial name
- NCT07439757
- Testing
- Diagnosis by Artificial Intelligence model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Autoimmune Diseases, Systemic Lupus Erythematosus
Exploratory Clinical Study on the Safety and Efficacy of Anti- CD19/BCMA U CAR-T Cell Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA U CAR T cells in patients with autoimmune diseases. 60 patients are planned to be enrolled in the dose-escalation trial.
- Conditions
- Autoimmune Diseases, Systemic Lupus Erythematosus, Systemic Sclerosis, Primary Sjögren Syndrome
- Trial name
- NCT07246096
- Testing
- anti-CD19/BCMA U CAR T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
CAR-NK Cells (CL-NK-003) in Pancreatic Cancer
This is a single-center, open-label, first-in-human, fixed-dose study in patients with pancreatic cancer.
- Trial name
- NCT07425483
- Testing
- CL-NK-003
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Changhai Hospital
Non-valvular Atrial Fibrillation (NVAF), High Risk of Stroke
A Prospective, Single-arm Study Evaluating the Endothelialization Effect and Timeline of AnchorMan® Left Atrial Appendage Occluder in Non-valvular Atrial Fibrillation Patients at High Risk of Stroke
This study aims to evaluate the endotheliation efficacy of the AnchorMane® Left Atrial Appendage Occluder in non-valvular atrial fibrillation patients at high stroke risk.
- Trial name
- AnchorMan-NVAF (NCT07396493)
- Testing
- Intra-operative application of LAAC
- Volunteers
- 306 people
- Sponsor
- Shanghai Zhongshan Hospital
Relapsed/Refractory Immune Nephropathy, Relapsed/Refractory Immune-mediated Kidney Disease
An Exploratory Clinical Study on the Safety and Efficacy of Anti-CD19/BCMA U CAR-T Cells in the Treatment of Relapsed/Refractory Immune-mediated Kidney Disease
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19/BCMA U CAR T cell injection (KN3601) in patients with Relapsed/Refractory immune-mediated kidney disease
- Trial name
- NCT07241468
- Testing
- anti-CD19/BCMA U CAR T
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changhai Hospital
Locally Advanced Rectal Carcinoma
A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer
The goal of this clinical trial is to compare the efficacy and safety of neoadjuvant chemoradiotherapy combined with tirelizumab compared with neoadjuvant chemoradiotherapy alone for neoadjuvant therapy in patients with locally…
- Trial name
- NCT06312982
- Testing
- Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 375 people
- Sponsor
- Beijing Friendship Hospital
Pancreatic Ductal Adenocarcinoma (PDAC), Circulating Tumor Cells (CTCs)
Mesenchymal CTC Ratio Dynamics Predicts Response and Survival in Pancreatic Ductal Adenocarcinoma With Neoadjuvant/Conversion Therapy
The aim of this study was to evaluate the clinical utility of mesenchymal CTC ratio dynamics as a real-time biomarker for PDAC patients with neoadjuvant therapy.
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC), Circulating Tumor Cells (CTCs), Neoadjuvant Therapy
- Trial name
- NCT07329920
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Guo ShiWei
Neoadjuvant Chemoradiation Therapy, Rectal Cancer
Neoadjuvant Chemoradiation Therapy Combined With Immunotherapy for MSS Ultra-low Rectal Cancer
At present, there are no relevant studies or reports on the effect of neoadjuvant chemoradiation therapy combined with immunotherapy for MSS ultra-low rectal cancer.
- Conditions
- Neoadjuvant Chemoradiation Therapy, Rectal Cancer, Immunotherapy, Microsatellite Instability Low
- Trial name
- NCT05215379
- Testing
- xintilimab injection, Control
- Where
- China
- Volunteers
- 201 people
- Sponsor
- Changhai Hospital
Postoperative Pain, Video-assisted Thoracoscopic Surgery (VATS)
Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on Postoperative Pain After Video-assisted Thoracoscopic Surgery
At present, surgical resection remains one of the main methods for the radical treatment of lung cancer. Compared with traditional thoracotomy, Video-assisted Thoracoscopic Surgery (VATS) offers obvious advantages, such as less…
- Trial name
- NCT06744166
- Testing
- TENS-WAA
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Changhai Hospital
Lumbar Spinal Stenosis (LSS), Degenerative Spondylolisthesis G1
Multicenter Clinical Randomized Controlled Trial of Unilateral Biportal Endoscopic Spinal Surgery for Degenerative Grade 1 Spondylolisthesis Complicated With Lumbar Spinal Stenosis
The research objective of this project is to clarify and compare the efficacy of the unilateral biportal endoscopy (UBE) technique and traditional open decompression, fusion and internal fixation surgery in the treatment of…
- Trial name
- NCT07303348
- Testing
- UBE, PLIF
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Pancreatic Neoplasms
Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic Cancer
This clinical trial will evaluate the safety and activity of mutant KRAS G12V-specific TCR transduced T cell therapy for advanced pancreatic cancer patients who express the KRAS G12V mutation and HLA-A*11:01 allele.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Pancreatic Ductal Adenocarcinoma, Advanced Cancer
- Trial name
- NCT04146298
- Testing
- Cyclophosphamide, Fludarabine, Mutant KRAS G12V-specific TCR transduced autologous T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
IgG4 Related Disease
An Exploratory Clinical Study on the Safety and Efficacy of CD19/BCMA CAR-NK in the Treatment of Relapsed and Refractory IgG4-related Disease
A single arm, open-label pilot study is designed to determine the safety and effectiveness of CD19/BCMA CAR NK cells (KN5601) in patients with IgG4 related diseases.
- Trial name
- NCT07298590
- Testing
- CD19/BCMA CAR NK
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital
Perioperative Analgesia, General Anaesthesia
Effect of Transcutaneous Electrical Nerve Stimulation Based on Wrist-ankle Acupuncture Theory on EC50 of Remifentanil Inhibiting Responses to Tracheal Intubation Under General Anesthesia
During endotracheal tube insertion under general anesthesia, sympathetic nerve activity increases, which leads to increased heart rate, increased blood pressure, and increased catecholamine levels in the blood.
- Trial name
- NCT06748898
- Testing
- TENS-WAA, non TENS-WAA
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Gastric Cancer, Gastric High-grade Intraepithelial Neoplasia
Establishment and Effectiveness Evaluation of a Training System for Confocal Laser Endomicroscopy
Gastrointestinal endoscopy is a vital method for screening and diagnosing gastric cancer. It aids in identifying the tumor's location within the stomach and its macroscopic type, and allows biopsy for histological confirmation.
- Conditions
- Gastric Cancer, Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT06981819
- Testing
- Probe-based Confocal Laser Endomicroscopy by Experts, magnifying endoscopy with blue laser imaging, Probe-based Confocal Laser Endomicroscopy by trainees
- Where
- China
- Volunteers
- 147 people
- Sponsor
- Changhai Hospital