Clinical trials: sponsored by Peking University First Hospital
Depression - Major Depressive Disorder
Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder
The goal of this project is to quantify the effectiveness and safety of escitalopram oxalate oral solution in the treatment of first-episode, drug-naïve patients with major depressive disorder, and to explore the mechanisms…
- Trial name
- NCT07480525
- Testing
- Escitalopram (Oral antidepressant)
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking University
Prostate Cancer, Radiation Therapy
Adjuvant Chemotherapy for High Malignant Prostate Cancer
This study aims to evaluate the efficacy of adjuvant docetaxel chemotherapy following radical radiotherapy in patients with localized high-grade prostate cancer.
- Conditions
- Prostate Cancer, Radiation Therapy, Chemotherapy, Gleason Score
- Trial name
- PKUFH-GS5 (NCT06864533)
- Testing
- Docetaxel
- Where
- 3 sites in China
- Volunteers
- 315 people
- Sponsor
- Peking University First Hospital
Primary Central Nervous System Lymphoma
Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL
This is a three-arm, multicenter, randomized controlled trial. Eligible participants will be randomized to one of three induction regimens via stratified block randomization at a 2:2:1 ratio.
- Trial name
- NCT07185373
- Testing
- Teniposide, Orelabrutinib, MTX
- Where
- 15 sites in China
- Volunteers
- 215 people
- Sponsor
- Huashan Hospital
Osteosarcoma, Osteosarcoma, Recurrent, Refractory
68Ga-B7-H3 Nanobody ImmunoPET in Osteosarcoma
This study aims to evaluate the safety, feasibility, and imaging performance of a novel 68Ga-labeled B7-H3 nanobody for immunoPET imaging in patients with osteosarcoma.
- Trial name
- NCT07774533
- Testing
- 68Ga-B7-H3 Nanobody PET/CT
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking University First Hospital
Urethra Stricture
LishitonglinUS-01 Trial
This study intends to conduct a prospective, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of Lishi Tonglin Granule (a hospital-formulated innovative prescription) developed in our…
- Trial name
- NCT07769060
- Testing
- Lishitonglin Formula granules
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University First Hospital
Malignant Tumor, Prehabilitation
Multimodal Prehabilitation for Tumor-Related Bowel Obstruction
The goal of this clinical trial is to establish a multimodal prehabilitation protocol suitable for patients with tumor-related bowel obstruction during the perioperative period, and to explore its safety and efficacy; to evaluate…
- Trial name
- NCT07767760
- Testing
- Multimodal prehabilitation program, Standard six-step treatment, ERAS protocol
- Where
- China
- Volunteers
- 394 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Gastric Cancer, Prehabilitation
Home-based Whole Course Multimodal Prehabilitation Based on 5G + Artificial Intelligence Mobile Health
The whole course management of gastric caner patients receiving neoadjuvant therapy frequently hinders by challenges such as inaccurate exercise plans, inadequate nutritional supplementary, limited access to timely psychological…
- Trial name
- mHealth prehab (NCT07764523)
- Testing
- mHealth prehabilitation group, ERAS group
- Where
- China
- Volunteers
- 328 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Ureteral Stricture, Dexmedetomidine
Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction
Anxiety and depressive symptoms are prevalent in patients undergoing surgical repair for ureteral stricture, driven by chronic pain, renal function concerns, and surgical uncertainty.
- Conditions
- Ureteral Stricture, Dexmedetomidine, Esketamine, Depressive Symptoms
- Trial name
- NCT07753772
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Peking University First Hospital
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Nutrition Assessment, Nutritional Support
The Effect of Perioperative Nutritional Assessment and Nutritional Support on Clinical Outcomes
It is a study to evaluate the relationship between preoperative nutritional assessment and clinical outcomes and to explore the effect of preoperative nutritional support on clinical outcomes in patients after abdominal operation.
- Conditions
- Nutrition Assessment, Nutritional Support, Clinical Outcomes, General Surgery
- Trial name
- PNAS (NCT03115931)
- Testing
- no intervention
- Where
- China
- Volunteers
- 4,880 people
- Sponsor
- Jinling Hospital, China
Fascia Iliaca Block, Liposomal Bupivacaine
Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Surgery
Patients after hip surgery often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications.
- Conditions
- Fascia Iliaca Block, Liposomal Bupivacaine, Postoperative Pain, Hip Surgery
- Trial name
- NCT07643792
- Testing
- Liposomal bupivacaine (LB), Plain bupivacaine
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Peking University First Hospital
Obstructive Sleep Apnea, Postoperative Analgesia
Oliceridine Versus Sufentanil Analgesia for Postoperative Patients With Obstructive Sleep Apnea
Opioids are frequently used for postoperative analgesia but may induce side effects. Opioid-induced respiratory depression is the most dangerous side effect of opioids.
- Conditions
- Obstructive Sleep Apnea, Postoperative Analgesia, Oliceridine, Sufentanil
- Trial name
- OSA (NCT07753785)
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 851 people
- Sponsor
- Peking University First Hospital
Gastric Cancer, Prehabilitation
Preoperative Home-based Multimodal Prehabilitation Based on 5G + Artificial Intelligence Mobile Health
The goal of this prospective, multicenter, open-label randomized controlled clinical trial is to evaluate whether a home-based, digitally supervised multi-modal prehabilitation intervention can improve functional capacity…
- Trial name
- NCT07755917
- Testing
- mHealth prehabilitation group, ERAS group
- Volunteers
- 490 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Older Adults, Surgery
Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients
Delayed neurocognitive recovery is a common neurocognitive complication in older patients after surgery, especially those with preoperative neurocognitive decline.
- Conditions
- Older Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive Recovery
- Trial name
- NCT07736092
- Testing
- Transcranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Intrapartum Maternal Fever, Clinical Chorioamnionitis
Association Between Neuraxial Labor Analgesia and Maternal and Neonatal Infectious Outcomes
The goal of this retrospective observational cohort study is to explore the associations between neuraxial labor analgesia and maternal-neonatal infectious outcomes among women attempting vaginal delivery, and to distinguish…
- Conditions
- Intrapartum Maternal Fever, Clinical Chorioamnionitis, Neonatal Infection
- Trial name
- NCT07751666
- Testing
- neuraxial labor analgesia
- Volunteers
- 49,000 people
- Sponsor
- Peking University First Hospital
Intracranial Aneurysm
Intelligent Microcatheter Shaping for Intracranial Aneurysm Coil Embolization
This prospective, multicenter, observational registry study will evaluate the real-world safety, effectiveness, and clinical value of artificial intelligence (AI)-assisted microcatheter shaping during coil embolization of…
- Trial name
- NCT07749404
- Testing
- Physician-Experience Microcatheter Shaping, AI-Assisted Microcatheter Shaping Simulation Technology
- Where
- China
- Volunteers
- 1,438 people
- Sponsor
- Xuanwu Hospital, Beijing
Leukemia, MDS
Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic Malignancy
Allogeneic hematopoietic stem cell transplantation is the only curative treatment for malignant hematologic diseases. However, immune rejection is a major limitation in its application.
- Conditions
- Leukemia, MDS, Lymphoma
- Trial name
- NCT06895538
- Testing
- Rabbit Anti-Human T-Lymphocyte Immunoglobulin (ATLG)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University First Hospital
Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) Relapse
A Phase I Single-arm Clinical Study of Donor NK Cells Infusion Combined With Low-dose Interleukin-2 in the Treatment of Acute Myeloid Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.
This is a single-centre, single-arm, open-label, early clinical study to evaluate the safety, tolerability and preliminary efficacy of donor NK cells injection combined with low-dose interleukin-2 in the treatment of acute…
- Conditions
- Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) Relapse, NK Cell
- Trial name
- NCT06641648
- Testing
- NK cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University First Hospital
Depression, Anxiety
Preoperative Anxiety and Depression Among Older Chinese Patients
A multicenter, cross-sectional study to characterize the clinical profiles of the Chinese elderly population and to determine the prevalence of preoperative anxiety and depression.
- Conditions
- Depression, Anxiety, Elderly Patients, Non-cardiac Major Surgery
- Trial name
- NCT07744295
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
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