Clinical trials: sponsored by Tata Memorial Centre
Gastric Cancer
"Phase III Randomized Trial Comparing D2 vs D3 Lymphadenectomy With Gastric Cancer Following Neoadjuvant Chemotherapy
Stomach cancer is the second most common cause of cancer-related deaths in India. Curative surgery offers the only chance of improving survival in this cancer.
- Trial name
- NCT02139605
- Testing
- D3 Lymphadenectomy
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Tata Memorial Centre
Cervical Cancer, Cervical Precancerous Lesions
Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India
The primary study hypothesis wasthat a two-dose human papillomavirus (HPV) vaccine regimen would offer similar immunogenicity and protection as that of a three-dose regimen to girls against persistent HPV infection and cervical…
- Trial name
- NCT00923702
- Testing
- Prophylactic quadrivalent HPV vaccine Merck (Gardasil®)
- Where
- 8 sites in India
- Volunteers
- 22,729 people, healthy volunteers welcome
- Sponsor
- Partha Basu
Septic Shock
Hemodynamic Resuscitation and Monitoring in Early Sepsis
"Hemodynamic Resuscitation and Monitoring in Early Sepsis (HERMES Study)" involves recording of patient's medical data related to that has been collected as part of his/her routine medical care in ICU.
- Trial name
- HERMES (NCT04143035)
- Testing
- No Intervention
- Where
- 246 sites in India
- Volunteers
- 500 people
- Sponsor
- Tata Memorial Centre
Breast Cancer Patients
Role of Exercise in Breast Cancer Patient Undergoing Treatment
Randomized controlled trial to evaluate the impact of yoga on QOL is also powered to evaluate the impact of yoga on survival. Study involves various phases of yoga(divided in three phases: Phase I/II/III) during treatment and…
- Trial name
- NCT05009849
- Testing
- Yoga Exercises
- Volunteers
- 850 people
- Sponsor
- Tata Memorial Centre
Operable Breast Neoplasms
Correlation of Predictive Accuracy of PREDICT Version 2.2 of Indian Women With Operable Breast Cancer
This is an observational retrospective study which aims at comparing the 5-year survival estimates from "PREDICT V2.2" with observed 5-year outcome from our dataset of Indian women treated for operable breast cancer.
- Trial name
- PREDICT (NCT04985253)
- Testing
- prediction of overall survival using Web based PREDICTV2.0 portal
- Where
- India
- Volunteers
- 2,780 people
- Sponsor
- Tata Memorial Centre
Non-Invasive Bladder Urothelial Carcinoma
Intravesical BCG: is the Urinary Bladder Ready to Receive it
Prospective cohort and Prospective observational study which aims To define the healing time-frame of the resected area of the bladder after TURBT.
- Trial name
- NCT05335512
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Centre
Hemorrhagic Cystitis
Chlorophyllin Tablets for Urinary Bleeding Following Radiation Therapy for Cancers of Pelvic Organs
To assess the efficacy of oral chlorophyllin tablets for urinary bleeding following radiation therapy for cancers of pelvic organs.
- Trial name
- CLARITY (NCT05348239)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Tata Memorial Centre
Uterine Cervical Neoplasms
Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer
The research group on adaptive image-guided radiotherapy for locally advanced cervical carcinoma completed the protocol for the EMBRACE II study in October 2018.
- Trial name
- EMBRACEII (NCT03617133)
- Testing
- Increased use of IC/IS technique in BT, Reduction of vaginal source loading, Systematic utilisation of IMRT
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Vienna
Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Surgery Vs Chemoradiation for Oropharyngeal Cancer- A Phase II/III Integrated Design Randomized Control Trial
The oropharyngeal areas mainly comprises of the tonsil, base tongue (BOT), soft palate and the posterior pharyngeal wall. Traditionally, surgical resection of oropharyngeal cancers (OPC) was a standard procedure, often performed…
- Trial name
- SCOPE (NCT05144100)
- Testing
- Surgery with or without Neck Dissection, Radiation, Cisplatin based chemotherpay
- Where
- India
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Pain
Comparison of Patient Controlled & Continuous Epidural Analgesia in Thoraco-abdominal Surgeries in Cancer Patients
This study aims to compare the efficacy of pain control, the consumption of local anesthetic and opioids, side effects, and patient satisfaction between continuous epidural infusion and patient controlled epidural analgesia after…
- Trial name
- NCT02803385
- Testing
- Continous Epidural Analgesia, Patient Controlled Epidural Analgesia
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Tata Memorial Centre
Cervical Cancer
An International Study on Magnetic Resonance Imaging (MRI)-Guided Brachytherapy in Locally Advanced Cervical Cancer
Background: The standard treatment of locally advanced cervical cancer is radio-chemotherapy including external beam radiotherapy (EBRT), brachytherapy (BT) and concomitant chemotherapy with weekly Cisplatin.
- Trial name
- EMBRACE (NCT00920920)
- Testing
- 3D MRI-guided Brachytherapy
- Where
- Austria
- Volunteers
- 1,416 people
- Sponsor
- Medical University of Vienna
Health Personnel Attitude, Health Knowledge, Attitudes, Practice
A Survey to Assess Knowledge, Attitudes & Practices in Surgeons With Regards to Breast Conservation Surgery & Mastectomy
With increasing evidence the management of breast cancer surgery has seen a paradigm shift towards breast conservation, heralding an era of oncoplastic breast surgery.
- Trial name
- NCT04799951
- Testing
- a survey questionnaire to find knowledge, attitude and practices in treatment of breast cancer.
- Where
- India
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Tata Memorial Centre
Breast Cancer Female, Neuropathic Pain
Prevalence of Paclitaxel Induced CIPN-Related Pain and CIPN in Indian Patients With Breast Cancer
Since its introduction in the 1970s, Paclitaxel has been used as an effective anticancer agent against lung, breast, ovarian, leukopenia and liver cancer.
- Trial name
- NCT03022162
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Tata Memorial Centre
Pain, Postoperative, Pain, Chronic
Pain and Impact of Chronic Pain on Function After Total Knee Replacements
After Institutional Review Board approval, adult patients scheduled for total knee arthroplasty (TKA) will be enrolled into the study after obtaining informed consent over a 24 month period.
- Conditions
- Pain, Postoperative, Pain, Chronic, Osteogenic Sarcoma, Knee Arthropathy
- Trial name
- NCT03032679
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 139 people
- Sponsor
- Tata Memorial Centre
Pain Syndrome, Mastectomy
Postmastectomy Pain Syndrome in an Indian Cancer Hospital
Breast cancer is the most common cancer in women in India and accounts for 27% of all cancers in women. Incidence rises in early thirties, peaks at 50-64 years. Approximately 48% are below 50 years of age.
- Conditions
- Pain Syndrome, Mastectomy, Quality of Life
- Trial name
- NCT03067922
- Testing
- Non interventional study
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tata Memorial Centre
Squamous Cell Carcinoma of the Head and Neck
Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial
The aim of the study is to test whether a resource-sparing 4-week, 20-fraction course of accelerated hypofractionated radiotherapy is non-inferior to accelerated radiotherapy delivering 33 fractions over 5.5 weeks in the…
- Trial name
- HYPNO (NCT02765503)
- Testing
- External beam radiotherapy
- Where
- 11 sites in Argentina, Cuba and 7 more
- Volunteers
- 836 people
- Sponsor
- International Atomic Energy Agency
Breast Carcinoma
Impact of Tumor Bed Localisation on Dosimetry Boost Irradiation in Patients Undergoing Breast Conserving Surgery
PRIMARY STUDY OBJECTIVES: To evaluate dosimetric outcomes in tumor bed boost irradiation in patients undergoing breast conservative surgery using three different surgical techniques SECONDARY OBJECTIVES- Evaluation of cosmesis in…
- Trial name
- NCT03710018
- Where
- India
- Volunteers
- 21 people
- Sponsor
- Tata Memorial Centre
Urological Cancer, Gastrointestinal Cancer
Correlation Between Intraocular Pressure Measurement by Tomometer and Anterior Chamber Depth Measurement by Ultrasound
Intra ocular pressure (IOP) may theoretically increase due to steep Trendelenberg position and studies showed that IOP reaches peak levels after steep Trendelenberg position on an average of 13 mmHg higher than preanesthesia…
- Conditions
- Urological Cancer, Gastrointestinal Cancer, Malignant Female Reproductive System Neoplasm
- Trial name
- NCT02818530
- Testing
- IOP by tonometer, Anterior chamber depth measurement by ultrasound
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Tata Memorial Centre
Chronic Cancer Pain
Validation and Assessment of Patient Adherence to Opioids for Cancer Pain Using MMAS 8 Pain Clinic
This study aims at finding degree of adherence of patients to their chronic pain medication prescriptions containing opioid e.g. Morphine, using Morisky Medication Adherence Scale 8, self- reported questionnaire.
- Trial name
- NCT02804477
- Where
- India
- Volunteers
- 330 people
- Sponsor
- Tata Memorial Centre
Mandibular Neoplasms
Inferior Alveolar Nerve Block for Intraoperative Analgesia for Maxillofacial Cancer Surgery - RCT
Mandibular resection which is an important component of maxillofacial cancer surgery is an extremely painful procedure associated with severe sympathetic response needing high doses of opioids.
- Trial name
- NCT02745288
- Testing
- inferior alveolar nerve block
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Tata Memorial Centre