Clinical trials: sponsored by University of Calgary
Elbow Fracture, Elbow Injury
PrEvention of Posttraumatic Joint contractuRes With Ketotifen 2
PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) is a Phase III randomized, controlled, double blinded multicenter trial with 3 parallel groups (Ketotifen 2 mg or 5 mg or lactose placebo twice daily orally for 6…
- Conditions
- Elbow Fracture, Elbow Injury, Elbow Dislocation
- Trial name
- PERK2 (NCT03582176)
- Testing
- Ketotifen Fumarate 2mg, Ketotifen Fumarate 5mg
- Where
- 15 sites in United States, Canada
- Volunteers
- 395 people
- Sponsor
- University of Calgary
Children Unable to Walk Independently
Upright Participation for Learners: Implementation of Flexible Use of roboT-assisted Walking in Schools - PILOT
Robot-assisted walking offers children who are unable to walk new avenues for participation in their communities in addition to health benefits. Disappointingly, most children cannot access this impactful technology.
- Trial name
- UPLIFTS Pilot (NCT07726706)
- Testing
- Robotic walking
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Tourette Syndrome
Transcranial Ultrasound Stimulation for Tourette Syndrome
This is a phase 1 clinical trial investigating the use of low-energy Transcranial Ultrasound Stimulation (TUS) to treat Tourette Syndrome (TS). Objectives and Background.
- Trial name
- TUS-TS (NCT07699783)
- Testing
- Focused ultrasound stimulation
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Intracerebral Hemorrhage Lobar
Evacuation of Lobar Intracranial Hemorrhage Using Microsurgical Technique (ELIMINATE)
ELIMINATE is a cohort study, phase 2A, designed to determine whether a standardized microsurgical procedure to evacuate spontaneous lobar intracranial hemorrhage (ICH) is feasible, safe and surgically efficacious in achieving a…
- Trial name
- ELIMINATE (NCT07697742)
- Testing
- Microsurgical hematoma evacuation
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Dr. Michael D Hill
Major Depressive Disorder (MDD)
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are…
- Trial name
- PERFORM-D (NCT06746155)
- Where
- 9 sites in Canada
- Volunteers
- 252 people
- Sponsor
- Abraham Nunes
Coronary Disease, Stroke
Assessing Outcomes of Enhanced Chronic Disease Care Through Patient Education and a Value-based Formulary Study
The purpose of this study is to determine the effect of two novel interventions; (1) a value-based formulary which eliminates copayment for selected high-value medications (proven to prevent heart attacks, stroke, and…
- Conditions
- Coronary Disease, Stroke, Chronic Kidney Disease, Heart Failure
- Trial name
- ACCESS (NCT02579655)
- Testing
- Copayment Elimination, Personalized Education
- Where
- Canada
- Volunteers
- 4,764 people
- Sponsor
- University of Calgary
Ischemic Stroke, Acute
Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial
Several clinical trials have produced variable conclusions regarding the effects of intensive blood pressure (BP) lowering in post-EVT acute ischaemic stroke (AIS) patients.
- Trial name
- ENCHANTED3/MT (NCT06352619)
- Testing
- Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
- Where
- 2 sites in Australia, Canada
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Stroke
ACT-GLOBAL Adaptive Platform Trial for Stroke
Stroke is causing 6.6 million deaths and is a major cause of disability worldwide in 2019. There remains an urgent need for interventions that improve outcomes which can be implemented with wide applicability for stroke.
- Trial name
- NCT06352632
- Testing
- Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase
- Where
- 2 sites in Australia, Canada
- Volunteers
- 20,000 people
- Sponsor
- The George Institute
Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL
This is a domain within the ACT-GLOBAL platform trial to compare the effectiveness of early and appropriate pharmacological interventions in acute intracerebral hemorrhage (ICH) to control secondary brain injury.
- Conditions
- Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage, Supratentorial Intracerebral Haemorrhage, Acute Intracerebral Haemorrhage
- Trial name
- INTERACT5 (NCT06763055)
- Testing
- Colchicine 0.5 mg, Deferoxamine Mesylate, Control (Standard treatment)
- Where
- 2 sites in Australia, China
- Volunteers
- 2,000 people
- Sponsor
- The George Institute
Diet, Healthy, Diabetes Mellitus, Type 2
Healthy Food Prescription Incentive Program
It is important for individuals with type 2 diabetes (T2DM) to adhere to a healthy dietary pattern to maintain optimal blood glucose levels and overall health.
- Conditions
- Diet, Healthy, Diabetes Mellitus, Type 2, Diabetes Complications
- Trial name
- NCT04725630
- Testing
- Healthy food incentive, Healthy food prescription
- Where
- Canada
- Volunteers
- 597 people
- Sponsor
- University of Calgary
Chronic Condition, Adverse Event
PAUSE: Sick Day Medication Management Mobile App Study
Diabetes, heart disease and kidney disease have high morbidity and costs of care. Medications used to treat these conditions are effective.
- Trial name
- PAUSE (NCT06433414)
- Testing
- PAUSE App
- Volunteers
- 320 people
- Sponsor
- University of Alberta
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Breast - Female
Feasibility of Imaging Breast Implants With a Transmission-based Microwave Scanner
The goal of this clinical trial is to assess whether microwave scans can depict the presence of implants in the breast in women with existing breast implants that were surgically placed at least 6 months ago.
- Trial name
- NCT07487792
- Testing
- WVI-MIS-03-2025
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Breast - Female
Feasibility of Comparing Microwave Images to Clinical Information in Patients Recalled for Follow-up Breast Imaging
The goal of this clinical trial is to measure the electrical properties of breast tissues using microwave technology and to compare these collected measurements to clinical information in mammograms and/or breast ultrasound for…
- Trial name
- NCT07273565
- Testing
- WVI-MIS-02-2025
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Moisture Associated Skin Damage, Fecal Incontinence
Testing a Novel Barrier Cream for Fecal Incontinence in an Ambulatory Population
Liquid stool and diarrhea are associated with an increased risk for moisture-associated skin damage (MASD), and clinical evidence suggests that exposure to liquid stool is associated with severe MASD and extensive erosion of…
- Conditions
- Moisture Associated Skin Damage, Fecal Incontinence, Incontinence Associated Dermatitis
- Trial name
- NCT06370637
- Testing
- Barrier Cream, Dermategrity Everyday Barrier Cream
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Scotiaderm
Prediabetes or Diabetes, Surgery Complications
The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes
The goal of this study is to measure the prevalence and risks of hyperglycemia in surgical patients with prediabetes. The main questions it aims to answer are: What is the prevalence of hyperglycemia in surgical patients with…
- Conditions
- Prediabetes or Diabetes, Surgery Complications, Non-Cardiac/ Non-Thoracic Surgery, Stress Hyperglycemia
- Trial name
- NCT07662980
- Where
- Canada
- Volunteers
- 750 people
- Sponsor
- University of Calgary
Anxiety and Depression
Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression
This is a parallel arm randomized (1:1) controlled trial. Adolescents aged 12-17 years (n=228) who are starting or changing a selective serotonin reuptake inhibitor (SSRI) for depression and/or anxiety will be randomly allocated…
- Trial name
- PGx-GAP (NCT06853587)
- Testing
- Pharmacogenetic-guided dosing, Current prescribing guidelines/recommendations
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- University of Calgary
Tetraplegia, Spinal Cord Injuries
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
- Trial name
- NCT04023591
- Testing
- Surgery/Occupational Therapy
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Cesarean Section Complications, Pain, Postoperative
Analgesic Efficacy of Surgeon-administered Transversus Abdominis Plane Blocks for Caesarean Section.
The purpose of this research study is to evaluate whether or not adding a Transversus Abdominis Plane Block (TAP block) improves pain control for patients having a cesarean section.
- Trial name
- NCT06324942
- Testing
- Surgeon-administered Transversus Abdominis Plane Block 0.25% bupivicaine 0.25 mL/kg
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary