Clinical trials: sponsored by Eisai Inc.
Impotence, Prostate Cancer
Evaluate the Effects of GPI 1485 on Erectile Function Following Bilateral Nerve-Sparing Prostatectomy
In this phase II study, an investigative (not approved by the FDA) drug called GPI 1485 is being assessed to see if it can help preserve erectile function after prostatectomy.
- Trial name
- NCT00090376
- Testing
- GPI 1485
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- Eisai Inc.
Postoperative Sedation, Intubation
GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
Patients who are in the intensive care unit after surgery and require mechanical breathing support (intubation and ventilation) usually require sedation to avoid agitation and excessive stress responses.
- Conditions
- Postoperative Sedation, Intubation, Respiration, Artificial
- Trial name
- NCT00125398
- Testing
- AQUAVAN (fospropofol disodium; GPI 15715 )
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eisai Inc.
Iron Deficiency Anemia, Helicobacter Pylori Infection
The Effect of H. Pylori Infection on Iron Metabolism
The purpose of this study is to determine if Helicobacter pylori (H. pylori) gastritis results in abnormal iron metabolism in patients with iron deficiency anemia (IDA), and to determine if this is due to strain variations in the…
- Trial name
- NCT00202488
- Testing
- H. pylori treatment
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Epilepsy, Mental Retardation
Open Label Study of Zonisamide in the Treatment of Epilepsy in Patients With Mental Retardation
The purpose of this study is to assess the efficacy and tolerability in "real-world" clinical practice, of adjunctive zonisamide treatment in adult patients with developmental disabilities and epilepsy.
- Conditions
- Epilepsy, Mental Retardation, Developmental Disabilities
- Trial name
- NCT00298818
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides
Study of ONTAK (Denileukin Diftitox) in Cutaneous T-Cell Lymphoma (CTCL) Patients
The purpose of this study is to compare the effectiveness of two dose levels of ONTAK (denileukin diftitox) in treating patients who have recurrent or persistent cutaneous T-cell lymphoma.
- Conditions
- Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides, Sezary Syndrome
- Trial name
- NCT00050999
- Testing
- ONTAK
- Where
- 35 sites in United States, Australia and 8 more
- Volunteers
- 195 people
- Sponsor
- Eisai Inc.
Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides
Study of ONTAK (Denileukin Diftitox) in Previously Treated Cutaneous T-Cell Lymphoma Patients
The purpose of this study is to provide an opportunity for patients who exhibit progressive disease while receiving placebo on the companion 93-04-11 study to receive ONTAK.
- Conditions
- Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides, Sezary Syndrome
- Trial name
- NCT00051012
- Testing
- ONTAK
- Where
- 34 sites in United States, Australia and 7 more
- Volunteers
- 86 people
- Sponsor
- Eisai Inc.
Kidney Neoplasms, Carcinoma, Renal Cell
A Safety, Tolerability and Efficacy Study of E7070 in Patients With Renal Cell Carcinoma
The purpose of this study is to determine if E7070 is a safe and effective treatment for cancer of the kidneys.
- Conditions
- Kidney Neoplasms, Carcinoma, Renal Cell, Adenocarcinoma, Renal Cell
- Trial name
- NCT00059735
- Testing
- E7070
- Where
- 5 sites in United States, France
- Volunteers
- 30 people
- Sponsor
- Eisai Inc.
Lymphoma, T-Cell, Cutaneous
Study of ONTAK® to Treat Cutaneous T-Cell Lymphoma (CTCL)
The purpose of this research study is to evaluate how effective ONTAK is in the treatment of cutaneous T-cell Lymphoma (CTCL) and determine whether the presence of a type of protein called CD25 on the cancer cells makes a…
- Trial name
- NCT00211198
- Testing
- ONTAK (denileukin difitox, DAB389IL-2)
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eisai Inc.
Chronic Myelogenous Leukemia
Phase II Trial of Decitabine in Patients With Chronic Myelogenous Leukemia Accelerated Phase Who Are Refractory to Imatinib Mesylate (Gleevec)
To determine the safety and efficacy of decitabine in patients with Philadelphia chromosome-positive chronic myelogenous leukemia accelerated phase that were previously treated with imatinib mesylate (STI 571) and became…
- Trial name
- NCT00041990
- Testing
- decitabine (5-aza-2'deoxycytidine)
- Where
- 8 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Astex Pharmaceuticals, Inc.
Newly Diagnosed Supratentorial Malignant Glioma
Radiation With Concomitant and Then Sequential Temozolomide in Malignant Glioma
To determine the safety and efficacy of Gliadel 3.85% wafers plus surgery and radiation with Temozolomide
- Trial name
- NCT00283543
- Testing
- Gliadel Wafer, Temozolomide, Limited field radiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kentuckiana Cancer Institute
Gastroesophageal Reflux Disease
Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD
The purpose of the study is to compare the effect of two different drugs, rabeprazole (20 mg) and pantoprazole (40 mg), and their effects on the amount of acid produced by your stomach on evening and at night after standard…
- Trial name
- NCT00304421
- Testing
- rabeprazole, pantoprazole
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Breast Neoplasms, Metastases
Study to Evaluate the Efficacy, Safety, and Tolerability of E7070 in Metastatic Breast Cancer Patients
The purpose of this study is to determine if E7070 is an efficacious, safe, and tolerable treatment for patients with metastatic breast cancer who have failed, or could not tolerate, prior treatments with an anthracycline, a…
- Trial name
- NCT00080197
- Testing
- E7070
- Where
- 35 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Eisai Inc.
Colorectal Cancer
An Open Label Phase II Study of Indisulam in Combination With Irinotecan in Patients With Metastatic Colorectal Cancer Who Have Been Previously Treated With 5-Fluorouracil/Leucovorin and Oxaliplatin
The overall purpose of this study is to determine the efficacy, safety and tolerability of indisulam in combination with irinotecan as a treatment for patients with metastatic colorectalcancer previously treated with…
- Trial name
- NCT00165867
- Testing
- E7070
- Where
- 7 sites in France, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Eisai Limited
Sepsis, Shock, Septic
A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis
Sepsis is a serious condition where there is inflammation and damage to body tissue, usually caused by an infection. This infection can lead to decreased function of vital body organs and in some cases may lead to permanent…
- Conditions
- Sepsis, Shock, Septic, Sepsis Syndrome, Septicemia
- Trial name
- NCT00046072
- Testing
- E5564
- Where
- 17 sites in United States
- Volunteers
- 300 people
- Sponsor
- Eisai Inc.