Clinical trials: sponsored by Duke University
Cervical Cancer, HPV Infection
1:1 Comparison of the Pocket Colposcope in Kenya
The Pocket colposcope has 510k FDA clearance and has been successfully used in almost 1500 unique patients globally in Duke and non-Duke protocols to date.
- Conditions
- Cervical Cancer, HPV Infection, HIV Infections
- Trial name
- NCT04998318
- Testing
- Pocket Colposcope, Standard of Care Colposcopy
- Where
- Kenya
- Volunteers
- 434 people
- Sponsor
- Duke University
Mental Disorder, Depressive Disorder
Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
A growing number of trials have demonstrated treatment effectiveness for mental illness by non-specialist providers, such as primary care providers, in low-resource settings.
- Conditions
- Mental Disorder, Depressive Disorder, Anxiety Disorder, Alcohol Use Disorder
- Trial name
- RESHAPE-cRCT (NCT04282915)
- Testing
- Reducing Stigma among Healthcare Providers (RESHAPE), mental health Gap Action Programme
- Where
- Nepal
- Volunteers
- 8,705 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diet, Healthy
Message Framing and Policy Support for Front-of-package Labeling
This study aims to assess whether different message framing about front-of-package labeling policies elicits more policy support than the control (no framing) among Latino and limited English proficiency populations.
- Trial name
- NCT06296342
- Testing
- Exposure to information framing message, Exposure to healthier choices framing message, Exposure to industry framing message
- Where
- United States
- Volunteers
- 4,107 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiac Rehabilitation, Health Coaching
Targeted Health Coaching to Improve Physical Activity Post-Structured Cardiac Rehabilitation
To identify factors and triggers influencing physical activity (PA) participation after structured cardiac rehabilitation (CR) among older adults who have enrolled in a center-based CR program, and compare the effects of a…
- Conditions
- Cardiac Rehabilitation, Health Coaching, Physical Activity
- Trial name
- Target-CR (NCT05773287)
- Testing
- Targeted Health Coaching Group, Standard Care Group
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Non-small Cell Lung Cancer
Phase Ib First in Human Dose Escalation of GT103 in Refractory, Advanced Stage Non-Small Cell Lung Cancer (TOP 1902)
The purpose of this research study is to determine the maximum tolerated dose of GT103 and investigate the safety and effectiveness of the study drug.
- Trial name
- NCT04314089
- Testing
- GT103
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Edward Patz
Neovascular Age-related Macular Degeneration
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age- Related Macular Degeneration
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects with Neovascular Age- Related Macular Degeneration
- Trial name
- NCT06495918
- Testing
- OTX-TKI, Aflibercept
- Where
- 97 sites in United States, Argentina and 2 more
- Volunteers
- 825 people
- Sponsor
- Ocular Therapeutix, Inc.
Chronic Kidney Disease, Hypertension
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy
This is a substudy of GUARDD-US (Genetic testing to Understand and Address Renal Disease Disparities across the United States, NCT04191824).
- Trial name
- GUARDD-US PGx (NCT06748040)
- Testing
- Timing of return of results
- Where
- 8 sites in United States
- Volunteers
- 1,874 people
- Sponsor
- Duke University
Migraine, Tension-Type Headache
Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types.
- Trial name
- NCT06745648
- Testing
- Arm A - Carotid Sinus Massage + Trendelenburg (CSM+T)
- Where
- Argentina
- Volunteers
- 18 people
- Sponsor
- Hospital Municipal Pedro T. Orellana
Brain Metastases, Adult
A Window of Opportunity Study of Patritumab Deruxtecan in Patients With Brain Metastases
The purpose of this study is to determine if the study drug, patritumab deruxtecan (HER3-DXd), can be measured in brain tumor tissue after recieving one dose of patritumab deruxtecan before surgery.
- Trial name
- PARAMETer (NCT05620914)
- Testing
- Patritumab deruxtecan
- Where
- United States
- Sponsor
- Mustafa Khasraw, MBChB, MD, FRCP, FRACP
Pain, Postoperative
Pain Profile and Pain Medication Use After THA and TKA
The over-prescription and overuse of opioid medications in the United States has recently been recognized as an epidemic. A new law in North Carolina (STOP Act) is aimed to limit opioid prescriptions following any surgical…
- Trial name
- NCT03714711
- Testing
- total hip arthroplasty, total knee arthroplasty
- Sponsor
- Duke University
Influenza, COVID-19
Comparative Immunogenicity of Concomitant vs Sequential mRNA COVID-19 and Influenza Vaccinations
This is a prospective, randomized randomized immunologic study of response to influenza and SARS-CoV-2 vaccination across four of the US Influenza Vaccine Effectiveness (Flu VE) Network study sites.
- Trial name
- NCT06020118
- Testing
- Simultaneous Vaccination (Influenza Vaccine and mRNA COVID booster), Sequential Vaccination (Influenza vaccine then mRNA COVID booster), Sequential Vaccination (mRNA COVID booster then Influenza vaccine)
- Where
- 8 sites in United States
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV Infections, Adolescent Behavior
Piloting a Smartphone App to Improve Treatment Adherence Among South African Adolescents Living With HIV
The overall goal of this pilot randomized-controlled trial (RCT) is to pilot MASI (MAsakhane Siphucule Impilo Yethu; Xhosa for "Let's empower each other and improve our health"), an ART adherence-supporting smartphone app with 50…
- Trial name
- NCT04661878
- Testing
- Social Support, Informational Resources, Self-Monitoring and habit formation
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- Duke University
Hypoxia
Optical Brain Pulse Monitor: Validation Of Cerebral Oximetry Monitoring (OBPM:VOCOM) Study.
The purpose of this study is to calibrate and validate a cerebral oximeter product from Cyban Pty. Ltd. The study will involve comparing cerebral oximeter signals against reference arterial and jugular bulb blood gas measures.
- Trial name
- OBPM:VOCOM (NCT06657820)
- Testing
- Hypoxia in healthy individuals, Cerebral Oximetry, Blood Gas Sampling
- Volunteers
- healthy volunteers welcome
- Sponsor
- Elliot Teo
Asthma, Obesity
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes
Patients with obese late onset (after childhood) asthma can have lower FeNO levels, yet be highly symptomatic and poorly responsive to inhaled steroids. This is a common asthma phenotype, particularly among females.
- Trial name
- SANDIA (NCT03885245)
- Testing
- L-ctirulline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Health Behavior
T2D Pilot Study for Patients With Uncontrolled Type 2 Diabetes
The primary objective of the study is to evaluate implementation and determine the effectiveness of a telehealth personal health planning program for individuals with uncontrolled Type 2 Diabetes Mellitus.
- Conditions
- Diabetes Mellitus, Health Behavior, Diabetes Mellitus, Type 2, Group Meetings
- Trial name
- NCT06988540
- Testing
- Personalized Health Planning Program Administration, Usual Care
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Duke University
Blood Pressure
Postpartum ASA and NT-proBNP
This study is a double-blinded randomized-controlled trial in which patients will be randomized to 81 mg of aspirin or placebo to be continued for 6 weeks' postpartum.
- Trial name
- NCT05889468
- Testing
- Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Duke University
X-linked Agammaglobulinemia, XLA
COVID-19 Vaccine Responses in PIDD Subjects
The goal of our study is to assess the cellular immune responses of participants with antibody deficiency disease before and after immunization with SARS-CoV-2 mRNA vaccines.
- Conditions
- X-linked Agammaglobulinemia, XLA, Primary Immune Deficiency, CVID
- Trial name
- NCT05321407
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Urinary Incontinence, Stress, Urinary Incontinence, Urge
Sling vs Botox for Mixed Incontinence
The primary aim is to compare the effectiveness of intradetrusor injection of 100 unit injection of Botulinum toxin A to mid-urethral sling for change in MUI symptoms 6 months following treatment.
- Trial name
- MUSA (NCT04171531)
- Testing
- Botox® injection, Mid-urethral sling
- Where
- 8 sites in United States
- Volunteers
- 150 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Fecal Incontinence, Bowel Incontinence
Neuromodulation for Accidental Bowel Leakage
This study is a multi-center, randomized clinical trial of women with refractory accidental bowel leakage (ABL) symptoms who have failed to achieve satisfactory symptom control from 2 first-line treatments for ABL: supervised…
- Trial name
- NOTABLe (NCT03278613)
- Testing
- ES-130
- Where
- 9 sites in United States
- Volunteers
- 166 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
ECMO Hemostatic Transfusions in Children
Critically ill children supported by extracorporeal membrane oxygenation (ECMO) receive large volumes of prophylactic platelet transfusions to prevent bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Thromboembolism, Transfusion Adverse Reaction
- Trial name
- ECSTATIC (NCT05796557)
- Testing
- Platelet Transfusion
- Where
- 10 sites in United States, Israel
- Volunteers
- 50 people
- Sponsor
- Yale University
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