Clinical trials: not yet recruiting
Acute Ischemic Stroke
Metformin in Acute Ischemic Stroke
The goal of this clinical trial is to study the efficacy of oral Metformin in Acute Ischemic Stroke (AIS). The main hypothesis is to study the efficacy of oral Metformin in patients with acute ischemic stroke presenting within 72…
- Trial name
- NCT07899307
- Testing
- Metfomin
- Where
- 4 sites in India
- Volunteers
- 440 people
- Sponsor
- All India Institute of Medical Sciences
Intractable Pain, Palliative Care
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
Background: Cancer-induced bone pain (CIBP) is common in people with cancer. Bone cancer can also lead to anxiety, depression, and reduced mobility and quality of life.
- Trial name
- NCT02522611
- Testing
- Resiniferatoxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Atrial Fibrillation (AF)
CATCH AF - Atrial Fibrillation Detection in Cryptogenic Stroke
Early detection of atrial fibrillation detected after stroke (AFDAS) is crucial for secondary stroke prevention, as initiating direct oral anticoagulants (DOACs) can reduce atrial fibrillation (AF)-related stroke risk by up to…
- Trial name
- CATCH-AF (NCT07899788)
- Testing
- CardioWatch 287-2 Group, Control Group
- Where
- Austria
- Volunteers
- 1,500 people
- Sponsor
- Medical University of Graz
Acute Kidney Injury
Effect of Filter Lifespan in CRRT on New Infections in Critically Ill Patients With AKI
This observational study aims to explore the factors that influence the risk of new infections in critically ill patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) in the UK.
- Trial name
- CRRTinfUK (NCT07903519)
- Where
- United Kingdom
- Volunteers
- 630 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diffusion Tensor Imaging Prognosis, Brain Injury, Traumatic
Description of Clinicians' Predictive Abilities Before and After a Diffusion Tensor Imaging (DTI)
With a mortality rate of over 13% in the neuro-intensive care unit, 86% of which are related to the withdrawal of active treatment, predicting a reliable neurological prognosis is of paramount importance in neuro-intensive care…
- Trial name
- Neuro-FORECAST (NCT07863414)
- Testing
- Questionnaire
- Where
- 8 sites in France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatic Heart Diseases, Scabies
Assessment of the Prevalence of Rheumatic Heart Disease in School Settings in Mayotte and the Acquisition of Ultrasound Sequences Guided by Artificial Intelligence
The prevalence of chronic rheumatic heart disease (RHD) on the island of Mayotte is unknown, but it appears to be high and is responsible for significant morbidity and mortality.
- Trial name
- PRECARE-MAYIA (NCT07904975)
- Testing
- Ultrasound performed bycardiologis for diagnosis of rheumatic heart disease
- Volunteers
- 900 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Sleep, Autism Spectrum Disorder
Transdiagnostic Sleep and Circadian Treatment for Autistic Adolescents
Sleep and circadian problems are associated with deleterious social, emotional, and cognitive outcomes, yet are modifiable. This prospective study will adapt and optimize an empirically supported behavioral intervention that…
- Conditions
- Sleep, Autism Spectrum Disorder, Transdiagnostic
- Trial name
- NCT07612111
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Palliative Care, Health Services, Palliative Care
Integrating Rhythmical Massage in Palliative Care
People receiving palliative and end-of-life care may experience pain, fatigue, sleep difficulties, anxiety, and other symptoms that affect their comfort and quality of life.
- Conditions
- Palliative Care, Health Services, Palliative Care, Massage Intervention
- Trial name
- NCT07904611
- Testing
- Rhythmic Massage
- Volunteers
- 70 people
- Sponsor
- Monash University Malaysia
Brain Neoplasms, Sleep Initiation and Maintenance Disorders
Lemborexant on Perioperative Sleep Quality in Patients With Brain Tumor Undergoing Surgery
This study tests whether lemborexant can improve perioperative sleep quality in people with brain tumor undergoing surgery. Adults with brain tumor scheduled for surgery may join.
- Trial name
- NCT07903051
- Testing
- Lemborexant 5 mg
- Volunteers
- 112 people
- Sponsor
- Beijing Tiantan Hospital
HIV Infection
HIV-1 Non-group M in Cameroon : Study of Genotypic and Phylogenetic Diversity (OBSOCAM)
The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.
- Trial name
- OBSOCAM (NCT06913959)
- Testing
- Prospective
- Volunteers
- 220 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Partial Edentulism
Digital and Conventional Clasp-retained Partial Dentures (DIGICLASP)
This single-center prospective observational cohort study evaluates two fabrication workflows already in routine clinical use for clasp-retained removable partial dentures (RPDs): a digital workflow (Group 1) and a conventional…
- Trial name
- DIGICLASP (NCT07903662)
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Bern
Contraceptive Behavior, Social Norms
Impact of Gender-Transformative Interventions on Contraceptive Use and Reproductive Autonomy in Somalia
Since 2019, the International Rescue Committee (IRC) has led family planning programming in Somalia under the Women's Integrated Sexual Health (WISH) program, funded by the United Kingdom's Foreign, Commonwealth and Development…
- Trial name
- FPIL-SOM (NCT07902700)
- Testing
- Intensive Gender-Transformative Programming, Light-Touch Gender-Transformative Programming, Standard Family Planning Services (WISH-2)
- Where
- Somalia
- Volunteers
- 5,436 people, healthy volunteers welcome
- Sponsor
- Guttmacher Institute
Organ Donation After Circulatory Death, Organ Donation
Improving Deceased Organ Donation and Transplantation Using the Donation Advisor Clinical Decision Support Tool
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Conditions
- Organ Donation After Circulatory Death, Organ Donation, Clinical Decision Support Tool
- Trial name
- DART (NCT07903428)
- Testing
- Donation Advisor clinical decision-support tool
- Volunteers
- 10 people
- Sponsor
- OBS Medical Ltd
Exercise-Induced Muscle Fatigue, Fatigue Recovery
ACUTE EFFECTS OF HIGH-INTENSITY LASER THERAPY ON PAIN, MUSCLE STIFFNESS, AND GRIP STRENGTH IN HEALTHY ADULTS
The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults.
- Conditions
- Exercise-Induced Muscle Fatigue, Fatigue Recovery, Health Adult Subjects, Healthy Adult
- Trial name
- HILT (NCT07895862)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Very Premature Baby
Effects of a Multisensory Intervention Program on the Term Behavior of the Very Premature Baby
The growth and organization of the cerebral cortex is ensured by the oligodendrocyte-rich subplate, whose proper development depends on both subcortical structures and sensory experiences.
- Trial name
- PIVOT (NCT07903766)
- Testing
- Multisensory intervention program, Standard care
- Volunteers
- 144 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Acute Pulmonary Embolism (PE)
CTEPH Differential Diagnosis Assisted by Enhanced Large Language Model Support
This randomized controlled trial aims to evaluate whether a locked large language model (LLM)-based clinical decision support system improves the differential diagnosis of pulmonary artery filling defects among physicians who do…
- Conditions
- Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Acute Pulmonary Embolism (PE), Pulmonary Artery Sarcoma
- Trial name
- NCT07902011
- Testing
- Locked CTEPH-LLM Diagnostic Decision Support
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Obesity
The Sleep and Weight Study
The purpose of this pilot study is to examine the implementation of a combined intervention targeting food cravings and sleep for adults with obesity in clinical settings.
- Trial name
- NCT07904663
- Testing
- Food Craving app, Sleep Coach app
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Spinocerebellar Ataxia Genotype Type 1, Spinocerebellar Ataxia Genotype Type 3
Cerebellar DBS in SCA1 and SCA3 Study
The purpose of this study is to evaluate the safety and feasibility of deep brain stimulation (DBS) in the deep cerebellar nuclei (DCN) in patients with Spinocerebellar Ataxia (SCA) types 1 and 3.
- Trial name
- NCT07752095
- Testing
- UG3NS140720 Deep Brain Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Gordon H. Baltuch
Thrombocytopenia
A Clinical Study Evaluating the Safety and Preliminary Effectiveness of Induced Pluripotent Stem Cell-derived Platelets in Patients With Thrombocytopenia Caused by Allogeneic Hematopoietic Stem Cell Transplantation
A multicenter open-label study with dose-escalation and multiple expansion cohorts, aimed at evaluating the safety and preliminary efficacy of IPSC-derived platelets in patients with thrombocytopenia caused by allogeneic…
- Trial name
- NCT07905144
- Testing
- iPSC-derived platelets
- Volunteers
- 9 people
- Sponsor
- Ruijin Hospital
Multiple Myeloma (MM)
QLS4131 for Relapsed/Refractory Multiple Myeloma With Extramedullary Disease
This is a prospective, single-arm, phase II clinical trial evaluating the efficacy and safety of QLS4131 in patients with relapsed/refractory multiple myeloma (RRMM) with extramedullary disease (EMD).
- Trial name
- BEYOND-MM 002 (NCT07903636)
- Testing
- QLS4131
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
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