Clinical trials: sponsored by Duke University
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
ECMO Hemostatic Transfusions in Children
Critically ill children supported by extracorporeal membrane oxygenation (ECMO) receive large volumes of prophylactic platelet transfusions to prevent bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Thromboembolism, Transfusion Adverse Reaction
- Trial name
- ECSTATIC (NCT05796557)
- Testing
- Platelet Transfusion
- Where
- 10 sites in United States, Israel
- Volunteers
- 50 people
- Sponsor
- Yale University
Hyperkalemia, End Stage Renal Disease
Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients
The purpose of this study is to determine whether once-daily dosing of patiromer will reduce the frequency of hyperkalemic episodes in ESRD (end stage renal disease) study participants who receive conventional hemodialysis (HD).
- Trial name
- NCT03781089
- Testing
- Patiromer Oral Powder Product
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
HIV, Stigma, Social
Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania
This study will test a stigma reduction intervention with women living with HIV in Tanzania.
- Conditions
- HIV, Stigma, Social, Self Efficacy, Self Esteem
- Trial name
- NCT05033002
- Testing
- Labda Siku Moja stigma reduction intervention
- Where
- Tanzania
- Volunteers
- 167 people
- Sponsor
- Duke University
Chronic Pain
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Chronic Pain Trial)
This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Trial name
- ADOPT PGx (NCT05966142)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 10 sites in United States
- Volunteers
- 1,048 people
- Sponsor
- Duke University
Bradycardia
Conduction System Pacing With INGEVITY+
The study is intended to evaluate the safety and effectiveness of the Boston Scientific INGEVITY+ cardiac pacing lead when implanted in the left bundle branch area (LBBA).
- Trial name
- INSIGHT-LBBA (NCT06014866)
- Testing
- Cardiac pacing
- Where
- 8 sites in United States
- Volunteers
- 1,383 people
- Sponsor
- Duke University
Generalised Anxiety Disorder
A Neuro-Technological Intervention for Adolescents With GAD
This study aims to evaluate the safety and acceptability of a basic neuro-technological intervention in the treatment of adolescents with Generalised Anxiety Disorder (GAD).
- Trial name
- NCT03813290
- Testing
- Neuro-technological Intervention
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National Healthcare Group, Singapore
Mortality
Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali
The LAKANA trial will assess the impact on mortality and other health outcomes of quarterly and biannual azithromycin mass drug administration (MDA) when delivered to 1-11-month (29-364 days) old infants in a high-mortality…
- Trial name
- LAKANA (NCT04424511)
- Testing
- Azithromycin
- Where
- Mali
- Volunteers
- 149,201 people, healthy volunteers welcome
- Sponsor
- Tampere University
Medication Therapy Management, Implementation Science
Senior PharmAssist: Co-Design and Evaluation of a Toolkit to Promote Scalable Implementation
This project aims to evaluate the scalability of an established, evidence-based, multi-component intervention, Senior PharmAssist^TM (SPA), designed to improve function and quality of life of older adults with limited incomes.
- Trial name
- NCT05278650
- Testing
- Senior PharmAssist^TM Program Implementation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Obesity, Sarcopenia
Pilot Study of the Human Metagenome in Metabolic Diseases
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
- Conditions
- Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation
- Trial name
- NCT06363253
- Testing
- No specific intervention
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Instability, Joint, Shoulder Dislocation
Quantitative MRI of Glenohumeral Cartilage & Labrum in Shoulder Instability
The purpose of this study is to assess cartilage strain and contact areas following glenohumeral instability compared to healthy individuals.
- Conditions
- Instability, Joint, Shoulder Dislocation, Shoulder Injuries, Shoulder Subluxation
- Trial name
- OREF (NCT05431114)
- Testing
- MRI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Brain Metastases, Adult, Primary Brain Tumor
Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy
This study represents a survivorship protocol that focuses on cognition and health-related quality of life (HRQoL) in cancer patients that have received prior brain irradiation.
- Conditions
- Brain Metastases, Adult, Primary Brain Tumor, Lung Cancer
- Trial name
- SPiRiT (NCT04567251)
- Testing
- Noona® application
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Cognition Disorder, Stroke
NeuroCognition After Carotid Recanalization
Complete occlusion of the Internal carotid artery (ICA) by atherosclerotic disease (COICA) causes approximately 15%-25% of ischemic strokes in the carotid artery distribution.
- Conditions
- Cognition Disorder, Stroke, Occlusion Carotid
- Trial name
- NIA-SCORE (NCT04219774)
- Testing
- Endovascular intervention, Aspirin and Clopidogrel (maximal medical Therapy)
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Guillain-Barre Syndrome
Peripheral Nerve Ultrasound for Diagnosis and Prognosis of Guillain-Barre Syndrome
The purpose of this study is to determine if peripheral nerve ultrasound can be used as a supplemental tool to diagnose Guillain-Barre syndrome (GBS) in the acute setting and aid in prognostication.
- Trial name
- NCT04053452
- Testing
- Peripheral nerve ultrasound, Measurement of strength
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Sickle Cell Disease
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers
The investigators are conducting a Phase II prospective and placebo controlled study of a topical cream containing sodium nitrite compared to the current standard of care.
- Trial name
- NCT02863068
- Testing
- Topical Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- caterina P minniti
Prostate Cancer
ARFI Imaging for Targeted Prostate Biopsy
The purpose of this study is to evaluate a new ultrasound technique. This technique may provide additional and improved information about the stiffness and sizes of the internal structures of your prostate in order to improve the…
- Trial name
- NCT04607135
- Testing
- Acoustic radiation force impulse (ARFI), Ultrasound
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Duke University
Energy Expenditure, Obesity
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up…
- Conditions
- Energy Expenditure, Obesity, Brown Adipose Tissue
- Trial name
- NCT04595006
- Testing
- Cold Stimulation (CS), Browning Nutraceutical (BN), Cold Stimulation and Browning Nutraceutical (CSBN)
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Lung Cancer
Lung Cancer Exercise Training Study
The purpose of the study is look at the effects of different types of exercise training with a stretching group and its effect on lung cancer patients.
- Trial name
- NCT01068210
- Testing
- Aerobic Training, Progressive Stretching, Resistance Training
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Myocardial Infarction
Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors)
Patients with partially blocked blood vessel(s) in their heart may need a medical procedure called "Percutaneous Coronary Intervention (PCI)" to open the narrowed blood vessel(s).
- Trial name
- NCT02939976
- Testing
- Single Vessel Disease, Multi-vessel Disease, Culprit Vessel Only, Multi-vessel Disease, Complete Revascularization
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- David Kong, M.D.
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
This is a randomized controlled trial to test a combination behavioral and biomedical interventions to improve the HIV prevention and care cascades in a population of mobile men in a high priority setting (fishermen in Kenya).
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, HIV Infections, Sexually Transmitted Diseases, Viral
- Trial name
- NCT04772469
- Testing
- Provision of multiple self-tests, Small monetary incentives, Use of SMS/text reminders to motivate adherence to ART or PrEP
- Where
- Kenya
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer Metastatic
DBT for Metastatic Lung Cancer
Metastatic lung cancer patients experience significantly greater psychological distress (i.e., depression, anxiety) compared to other cancers.
- Trial name
- LiveWell (NCT04973436)
- Testing
- Dialectical Behavioral Therapy Skills Training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
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