Clinical trials: sponsored by Duke University
Rheumatoid Arthritis
Weight Loss and Exercise To Improve Rheumatoid Arthritis Cardiovascular Risk
This is a small exploratory, randomized, controlled trial. Twenty-six older (ages 60-80 yr.), obese (BMI 28-40 kg/m2) persons with rheumatoid arthritis (RA) (seropositive or erosive) will be randomized to 16 weeks of a counseling…
- Trial name
- SWET/CHAT (NCT04356183)
- Testing
- SWET: Supervised Weight loss and Exercise Training, CHAT: Counseling Health As Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
HIV
A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum
This is a multicenter, open-label, phase 1 clinical trial to test two human immunodeficiency virus (HIV) vaccines with two adjuvants.
- Trial name
- NCT06267872
- Testing
- CD4BS CH505M5 Pr-NP1, CH505TF chTrimer, 3M-052-AF (labeled as AP 60-702)
- Where
- 6 sites in United States, South Africa
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Steroid Diabetes
Effect of Corticosteroid Injections on Blood Glucose
The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Shoulder Osteoarthritis, Knee Osteoarthritis
- Trial name
- CSI (NCT05048264)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Post-traumatic Osteoarthritis, Unspecified Ankle and Foot, Localized, Primary Osteoarthritis of the Ankle and/or Foot
Prospective Subtalar, Double, or Triple Arthrodesis Study With CCS Screws
The objective of this study is to prospectively evaluate the mid-term results and intraoperative and postoperative complication rate in patients who underwent double or triple arthrodesis using CCS screws.
- Trial name
- NCT02619838
- Testing
- Aptus CCS 5.0 or/and 7.0 screws
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Wound of Skin
DermaClose DUKE Fasciotomy and Wound Study
To evaluate the clinical performance of DermaClose and DermaClose XL Continuous External Tissue Expander (CETE) devices to reduce wound size and/or assist with closure in acute full thickness wounds of the skin and assess the…
- Trial name
- NCT05330767
- Testing
- DermaClose Continuous External Tissue Expander Device, DermaClose XL Continuous External Tissue Expander Device, Conventional wound dressings
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baxter Healthcare Corporation
Lung Transplant Failure and Rejection
Clinical Trials in Organ Transplantation Extension Study
The purpose of the study is to continue to follow subjects who were enrolled in the CTOT-20 CLAD Phenotypes study. Subjects will provide clinical data and complete quality of life questionnaires that will be used to determine the…
- Trial name
- CTOT-ES (NCT04126746)
- Where
- 5 sites in United States, Canada
- Volunteers
- 501 people
- Sponsor
- Duke University
Neonatal Critical Illness, Pediatric Critical Illness
Decision Making Support for Parents and Caregivers
The purpose of this study is to test the feasibility and acceptability of a tool to support decision making for parents of critically ill infants.
- Trial name
- NCT05733975
- Testing
- Decision Making Guide
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Duke University
Covid19
Epidemiologic Intelligence Network (EpI-Net) to Promote COVID-19 Testing
The investigators propose a mixed-methods intervention design to evaluate the acceptability of epidemic intelligence (EpI-Net) intervention using Community Engagement (CE) principles to promote COVID-19 testing and prevention…
- Trial name
- EpI-Net (NCT04910542)
- Testing
- Epi-Net Intervention
- Where
- Puerto Rico
- Volunteers
- 3,301 people, healthy volunteers welcome
- Sponsor
- Ponce Medical School Foundation, Inc.
Well-being of Caregivers (Caregiver Strain Index)
A Phase 2 Study of Home Care Following Autologous Hematopoietic Stem Cell Transplantation
This is a research study to compare the well-being (caregiver strain index) of caregivers of patients receiving home vs standard care after autologous hematopoietic stem cell transplant.
- Trial name
- NCT03667599
- Testing
- home care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Adherence, Patient, Pre-Exposure Prophylaxis
mHealth Technologies to Enhance PrEP Adherence Among Thai MSM
This study aims to: 1) adapt the theory-based P3 (Prepared, Protected, emPowered) app designed to improve pre-exposure prophylaxis (PrEP) adherence, retention in PrEP clinical care, and PrEP persistence among young gay, bisexual…
- Conditions
- Adherence, Patient, Pre-Exposure Prophylaxis, HIV/AIDS
- Trial name
- P3-T (NCT04413708)
- Testing
- P3-T PrEP Adherence App
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Immunization
mHealth-Assisted Conditional Cash Transfers to Improve Timeliness of Vaccinations (D0271)
Vaccination is a cost-effective strategy for conferring immunity against a host of preventable diseases, however, rates of timely childhood vaccinations remain inadequate in resource-limited settings.
- Trial name
- MINT (NCT03252288)
- Testing
- Reminders, Conditional financial transfers
- Where
- Tanzania
- Volunteers
- 412 people
- Sponsor
- Duke University
Mental Health Issue, Family Relations
An Evaluation of a Family Counseling Intervention ("Tuko Pamoja") in Kenya
The purpose of this study is to evaluate a family counseling intervention, entitled "Tuko Pamoja" (Translation "We are Together" in Kiswahili).
- Conditions
- Mental Health Issue, Family Relations, Family Conflict, Child Mental Disorder
- Trial name
- C0058 (4C) (NCT06417918)
- Testing
- Tuko Pamoja, "We are Together" in Kiswahili
- Where
- Kenya
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Duke University
Dementia, Stress
Stress Management Toolkit for People Living With Dementia and Their Care Partners
The purpose of this study is to develop a prototype of a home-based, dyadic tangible toolkit comprised of simple tools to help people living with dementia (PLWD) and their care partners manage stress at home.
- Conditions
- Dementia, Stress, Caregiver Burden
- Trial name
- NCT05465551
- Testing
- Stress Management Toolkit
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Suicidal Ideation
SAFETY-A for Promoting Equity in Suicide Prevention Outcomes in Schools
This study will adapt Safe Alternatives For Teens and Youth - Acute (SAFETY-A) for implementation in low-resourced school districts to reduce racial/ethnic disparities in mental health service use (MHS) following identification…
- Trial name
- NCT05834660
- Testing
- Safe Alternatives for Teens and Youth-Acute for Schools (SAFETY-A for Schools)
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- University of California, Los Angeles
Influenza Viral Infections
Single Dose Texas 2017 (H3N2) Challenge Study
The overall objective of the present study is to utilize the recombinant H3N2 (A/Texas/71/2017 (H3N2, clade 3C3a)) influenza virus for a controlled human infection model to study host responses to influenza virus with the aim of…
- Trial name
- NCT06476275
- Testing
- Influenza A/Texas/71/2017 (H3N2)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Covid19
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis
A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge
- Trial name
- NCT04650087
- Testing
- Apixaban 2.5 MG
- Where
- 121 sites in United States
- Volunteers
- 1,291 people
- Sponsor
- Thomas L. Ortel
Autism Spectrum Disorder
Open Label Phase I hCT-MSC in Toddlers With Autism Spectrum Disorder
This is a single site, prospective study of one intravenous infusion of human umbilical cord tissue-derived mesenchymal stromal cells (hCT-MSC) in toddlers with autism spectrum disorder (ASD).
- Trial name
- TACT (NCT04294290)
- Testing
- hCT-MSC infusion
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Dog Therapy
Impact of Therapy Dog Presence on Pediatric Echocardiogram
Young children with known or suspected heart disease frequently have difficulty cooperating with a clinically ordered echocardiogram. Current distraction techniques vary in efficacy.
- Trial name
- NCT03059407
- Testing
- Dog therapy only, Dog plus standard distraction tech, Standard distraction techniques only
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Duke University
Behavior Problem, Mental Disorder
FCT Study: Reducing the Need for Out-of-Home Placements
Does Family Centered Treatment (FCT) result in better youth, family, and cost outcomes, as compared to a Level II or Level III out-of-home placement (OHP)? The investigators test the hypotheses that among children/youth…
- Conditions
- Behavior Problem, Mental Disorder, Emotional Problem
- Trial name
- 2018-0568 (NCT03641664)
- Testing
- Family Centered Treatment, Level II or Level III Out of Home Placement
- Where
- 2 sites in United States
- Volunteers
- 750 people
- Sponsor
- Duke University
Conduct Disorder, Anti-Social Behavior
Multisite Prevention of Conduct Problems (Fast Track)
The primary aim of this project is to evaluate the effects of a comprehensive intervention to prevent severe and chronic conduct problems in a sample of children selected as high-risk when they first entered school.
- Trial name
- NCT01653535
- Testing
- Fast Track
- Where
- United States
- Volunteers
- 891 people, healthy volunteers welcome
- Sponsor
- Duke University
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