Clinical trials: sponsored by Emory University
Hematological Malignancies, Thrombocytopenia
PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid)
STUDY BACKGROUND AND PURPOSE: Patients with hematological malignancies (blood-related cancers) often develop thrombocytopenia (low platelet count), which can be made worse by cancer treatment.
- Trial name
- PROBLEMA (NCT02074436)
- Testing
- EACA, Platelet transfusion
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Cardiovascular Disease, Sarcopenia
Trial of Oral Glutamine on Mitochondrial Function in CKD
The primary goal of proposed investigation is to study the impact of oral glutamine supplementation on muscle mitochondrial and endothelial cell function measured mitochondrial energetics and vascular function using 31P magnetic…
- Conditions
- Cardiovascular Disease, Sarcopenia, Endothelial Dysfunction, Muscle Mitochondrial Function
- Trial name
- NCT02838979
- Testing
- First Intervention (14 days), Washout (3 weeks), Second Intervention (14 days)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Washington
Autism Spectrum Disorder
Mobilizing Community Systems to Engage Families in Early Autism Spectrum Disorder (ASD) Detection & Services
This multisite study will compare the effectiveness of universal screening by 3 community service systems using Autism Navigator, a highly interactive web platform that includes an automated screening tool, information about…
- Trial name
- NCT02445105
- Testing
- Autism Navigator Enhanced Practice, Family Engagement plus Autism Navigator
- Where
- 4 sites in United States
- Volunteers
- 10,857 people
- Sponsor
- Florida State University
Influenza
The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics
The goal of this study is to understand the impact on the human immune system's response to the four strain flu vaccine in individuals who have "imprinted" on specific influenza strains.
- Trial name
- FLU2 (NCT03686514)
- Testing
- FLUARIX QUADRIVALENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Emory University
Tuberculosis
Electronic Pillbox-enabled SAT Versus DOT for TB Medication Adherence and Treatment Outcomes
To address the multifaceted challenges associated with tuberculosis (TB) in-person directly observed therapy (DOT), the World Health Organization recently recommended countries maximize the use of digital adherence technologies.
- Trial name
- SELFTB (NCT04216420)
- Testing
- MERM-observed self-administered therapy
- Where
- Ethiopia
- Volunteers
- 114 people
- Sponsor
- Addis Ababa University
HRD, Cholangiocarcinoma
Maintenance Niraparib and Dostarlimab in Advanced Cholangiocarcinoma
Phase II, single arm trial, evaluating molecularly selected, immune-based combination therapy in maintenance treatments for advanced cholangiocarcinoma, selecting patients on the homologous recombination deficient (HRD) signature.
- Conditions
- HRD, Cholangiocarcinoma, Metastatic Cancer
- Trial name
- NCT04895046
- Testing
- Niraparib, Dostarlimab
- Sponsor
- Walid Shaib, MD
Breast Cancer
To Enhance Breast Cancer Survivorship of Asian Americans
The purpose of this randomized intervention study is to test the efficacy of the technology-based information and coaching/support program for Asian American breast cancer survivors (TICAA) in enhancing the women's breast cancer…
- Trial name
- TICAA (NCT02803593)
- Testing
- Technology-based information and coaching/support program, American Cancer Society information on breast cancer
- Where
- 2 sites in United States
- Volunteers
- 199 people
- Sponsor
- Emory University
Acute Myeloid Leukemia, AML, Childhood
AflacLL1901 (CHOA-AML)
The investigators propose to study an Aflac-AML chemotherapy backbone prospectively to validate its use in all pediatric AML and to further evaluate the cardiotoxicity with this approach for low risk AML.
- Trial name
- NCT04326439
- Testing
- Cytarabine, Daunorubicin, Erwinase
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Critical Illness
The Energy Dose Study
The investigators have designed this single-center Randomized Clinical Trial (RCT) to prospectively compare, for the first time, the clinical efficacy of different energy doses in intensive care unit (ICU) patients requiring…
- Trial name
- NCT01369147
- Testing
- Parenteral Nutrition, Propofol, Clevidipine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Emory University
Pregnancy
Effects of Prenatal DHA Supplements on Infant Development
This research study research is about the significance of polyunsaturated fatty acids (PUFAs) for human development. Specifically, the study team will assess the effect of docosahexanoic acid (DHA) supplementation during…
- Trial name
- NCT00646360
- Testing
- DHA
- Where
- Mexico
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- Emory University
Dementia
Dementia-Friendly Faith Villages to Support African American Families
The purpose of this project is to develop and test the feasibility and preliminary effects of a program to enhance the capacity of predominantly African American churches to support congregants and their family caregivers who are…
- Trial name
- NCT04983693
- Testing
- Dementia-friendly Worship Service
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Emory University
Hepatitis C
Registry-based HCV Care Cascade Navigation at Atlanta's Grady Memorial Hospital
This study seeks to implement and evaluate a data-driven case navigation system for hepatitis C virus (HCV) treatment among persons who are either actively injecting drugs or who are receiving opioid substitution therapy (OST).
- Trial name
- EZ-C (NCT03441542)
- Testing
- Data-assisted Case Navigation, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Opinion Research Center
Human Immunodeficiency Virus
Linking Persons With HIV, Discharged From Jail, With Community Care
This is a prospective cohort study of outcomes of individuals who entered jail during a period during which one of three serial HIV testing strategies is implemented. This study involves two sub-studies.
- Trial name
- NCT04560556
- Testing
- Point-of-Care (POC) Rapid HIV Test, Fourth Generation Antigen/antibody (Ag/Ab) HIV Test
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Emory University
Masks
Assessment of Cloth Face Coverings as Source Control Under Laboratory and Simulated Field Conditions
Cloth masks have been evaluated as a potential substitute for personal protective equipment (PPE) and found lacking. Prior to the COVID-19 outbreak, the use of cloth masks was limited and the focus of the limited research…
- Trial name
- NCT05216939
- Testing
- Flannel mask with ear loops, Flannel mask with ties, Twill mask with ear loops
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
COVID-19, Oscillation and Lung Expansion
Oscillation and Lung Expansion Therapy in Patients With COVID-19
A Pilot Study of the Use of Oscillation and Lung Expansion (OLE) Therapy in Patients Hospitalized with COVID-19
- Trial name
- NCT04582214
- Testing
- MetaNeb® System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Hill-Rom
Congenital Heart Disease
SVR III: Brain Connectome and Neurodevelopmental Outcomes
Patients with hypoplastic left heart syndrome and other single right ventricle lesions who have undergone the Fontan procedure have a high risk of neurodevelopmental disorders that affect quality of life and adulthood employment.
- Trial name
- SVRIII (NCT02692443)
- Testing
- Magnetic Resonance Imaging, Neurodevelopmental Testing
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Antisocial Behavior, Psychopathology
Age-17 Follow-up of Home Visiting Intervention
This study is a longitudinal follow-up of 670 primarily African-American women and their 17-year-old firstborn children enrolled since 1990 in a highly significant randomized controlled trial (RCT) of prenatal and infancy home…
- Conditions
- Antisocial Behavior, Psychopathology, Substance Use, HIV Infections
- Trial name
- MemphisY17 (NCT00708695)
- Testing
- Nurse Home Visiting
- Where
- United States
- Volunteers
- 1,880 people
- Sponsor
- University of Colorado, Denver
Major Depressive Disorder, Overweight
Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach
This project aims to evaluate whether a dose-response relationship exists between dose of polyunsaturated fatty acids (PUFA), delivered as eicosapentaenoic acid (EPA), and change in markers of inflammation, and whether these…
- Conditions
- Major Depressive Disorder, Overweight, Inflammation
- Trial name
- NCT02553915
- Testing
- EPA 1 g/day, EPA 2 g/day, EPA 4 g/day
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Post-Partum
Prevent Maternal Mortality Using Mobile Technology
Black women who reside in a rural area are at highest risk for maternal morbidity and mortality due to a combination of social and structural causes.
- Trial name
- NCT05339867
- Testing
- Prevent Maternal Mortality using Mobile technology (PM3)
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Emory University
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