Clinical trials: sponsored by Peking University First Hospital
Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) Relapse
A Phase I Single-arm Clinical Study of Donor NK Cells Infusion Combined With Low-dose Interleukin-2 in the Treatment of Acute Myeloid Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.
This is a single-centre, single-arm, open-label, early clinical study to evaluate the safety, tolerability and preliminary efficacy of donor NK cells injection combined with low-dose interleukin-2 in the treatment of acute…
- Conditions
- Acute Myeloid Leukemia (AML), Acute Myeloid Leukemia (AML) Relapse, NK Cell
- Trial name
- NCT06641648
- Testing
- NK cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking University First Hospital
Leukemia, MDS
Comparison of ATLG and ATG for Immune Reconstitution After Allo-HSCT for Hematologic Malignancy
Allogeneic hematopoietic stem cell transplantation is the only curative treatment for malignant hematologic diseases. However, immune rejection is a major limitation in its application.
- Conditions
- Leukemia, MDS, Lymphoma
- Trial name
- NCT06895538
- Testing
- Rabbit Anti-Human T-Lymphocyte Immunoglobulin (ATLG)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking University First Hospital
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Embolism Acute
Pulsatile Electrical Impedance Tomography for Diagnosis and Monitoring of Acute Pulmonary Embolism
This multicenter observational diagnostic study aims to evaluate pulsatile electrical impedance tomography (EIT) for the diagnosis and monitoring of acute pulmonary embolism.
- Trial name
- EIT-PE (NCT07724197)
- Testing
- Pulsatile Electrical Impedance Tomography
- Where
- 4 sites in China
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Depression, Anxiety
Preoperative Anxiety and Depression Among Older Chinese Patients
A multicenter, cross-sectional study to characterize the clinical profiles of the Chinese elderly population and to determine the prevalence of preoperative anxiety and depression.
- Conditions
- Depression, Anxiety, Elderly Patients, Non-cardiac Major Surgery
- Trial name
- NCT07744295
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Multiple Myeloma and Other Plasma Cell Neoplasms
Longitudinal Data Registry of Plasma Cell Dyscrasia
The goal of this multicenter observational study is to better understand the clinical and molecular characteristics, disease progression, treatment response, and clinical outcomes of patients with plasma cell dyscrasias…
- Trial name
- NCT06760052
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Comprehensive Complication Index
Assessing the Effectiveness of Continuous Glucose Monitoring in Enhancing Surgical Outcomes for Patients With Diabetes
The goal of this multi-center, pragmatic, randomized controlled trial is to assess the effectiveness of continuous glucose monitoring (CGM) compared with conventional monitoring in enhancing surgical outcomes for diabetic…
- Trial name
- NCT06331923
- Testing
- Continuous glucose monitoring (CGM) device
- Where
- 8 sites in China
- Volunteers
- 9,877 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Phelan-McDermid Syndrome, SHANK3 Haploinsufficiency
RB001 Gene Therapy Study in Children With SHANK3-related Phelan-McDermid Syndrome (PMS)
This is an open-label, dose-escalation study to evaluate the safety, tolerability, and clinical activity of a single dose of RB001 administered via intracerebroventricular (ICV) injection in pediatric with SHANK3 related…
- Trial name
- NCT07014020
- Testing
- RB001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University First Hospital
Tetanus
A Study of Tetanus Antibody of Healthy Adults
The goal of this observational study is to learn about antibody level of tetanus of adults in high-income city of china. The main question it aims to answer is: 1.
- Trial name
- tetanus (NCT07724379)
- Where
- China
- Volunteers
- 2,009 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Cutaneous T-Cell Lymphoma/Mycosis Fungoides, Primary Cutaneous Anaplastic Large Cell Lymphoma
Efficacy and Safety of Brentuximab Vedotin Combined With Lisaftoclax in CD30+ Cutaneous T-cell Lymphoma (CTCL)
This is a prospective, single-center, open-label, randomized, controlled phase II clinical trial. The main purpose of this study is to evaluate the efficacy and safety of combining brentuximab vedotin (an anti-CD30 antibody-drug…
- Trial name
- BV-LISA-CTCL (NCT07717580)
- Testing
- Brentuximab Vedotin (Bv), Lisaftoclax (APG-2575)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Peking University First Hospital
Colorectal Cancer, Advanced Neoplasia
Development and Validation of a Colorectal Cancer Diagnostic Model
This is a multicenter, observational study designed to develop and validate a diagnostic model for colorectal cancer and advanced colorectal neoplasia among adults undergoing routine-care colonoscopy in the Chinese population.
- Conditions
- Colorectal Cancer, Advanced Neoplasia, Prediction Models, Risk Stratification
- Trial name
- NCT07692555
- Where
- 4 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Bladder Urothelial Carcinoma, Bladder Cancer
Sun Yat-Sen Treatment Strategy for Enhancing Response in Muscle-invasive Bladder Cancer
This is a multicenter, prospective, open-label, Phase II, four-arm parallel study evaluating the efficacy and safety of different sensitization strategies combined with disitamab vedotin and toripalimab in patients with…
- Trial name
- SYSTEM (NCT07717242)
- Testing
- Disitamab vedotin, Toripalimab, Sitagliptin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Anesthesia, General, Major Abdominal Surgeries
The Impact of Multimodal Brain Monitoring on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery
The purpose of this clinical trial is to investigate the effect of multimodal brain monitoring under general anesthesia on postoperative outcomes in elderly patients undergoing abdominal surgery.The research hypothesis is that…
- Trial name
- NCT07713355
- Testing
- Multimodal brain monitoring guided anesthesia, Bispectral Index(BIS) monitoring guided anesthesia
- Where
- 4 sites in China
- Volunteers
- 368 people
- Sponsor
- Xuanwu Hospital, Beijing
Pregnancy Complication, Aortic Dissection
PregnAncy-Related Aortic DISsEction in China
A multicenter observational study on pregnancy-related aortic dissection
- Conditions
- Pregnancy Complication, Aortic Dissection, Marfan Syndrome, Loeys-Dietz Syndrome
- Trial name
- PARADISE (NCT07672210)
- Testing
- Intervention strategies including medication or surgery
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- DeltaHealth Hospital · Shanghai
Chest Pain Center, STEMI - ST Elevation Myocardial Infarction
Current Status and Determinants of Care for Patients With Acute Chest Pain in China: A Retrospective Analysis of Data From the China Chest Pain Center Registry
Chinese Cardiovascular Association is an association dedicated to establishing Chest Pain Centers in hospitals that have basic qualifications and meet pre-designed quality control targets.The vision of Chinese Cardiovascular…
- Conditions
- Chest Pain Center, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Unstable Angina (UA)
- Trial name
- NCT04014972
- Volunteers
- 3,000,000 people
- Sponsor
- China Cardiovascular Association
Prostate Cancer
Radioactive Counts From PSMA PET/CT-Targeted Biopsy Specimens for Real-time Diagnosis of Prostate Cancer: A Prospective Study
This study aims to establish the diagnostic threshold and efficacy of radioactive counts (CPM) from biopsy specimens in distinguishing cancer-containing from non-cancer-containing cores, using prostate biopsy pathology as the…
- Trial name
- NCT07709403
- Testing
- No intervention (observational study)
- Volunteers
- 20 people
- Sponsor
- Peking University First Hospital
Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS
PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke
This study is a prospective, multicenter, double-blind, randomized, placebo-controlled clinical trial designed to evaluate whether early administration of PCSK9 inhibitors can effectively improve functional outcomes at 90 days in…
- Conditions
- Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS, Atherosclerotic Plaque
- Trial name
- PISTIAS-3 (NCT07466251)
- Testing
- Recaticimab plus standard therapy
- Where
- 19 sites in China
- Volunteers
- 1,212 people
- Sponsor
- Peking Union Medical College Hospital
Sleep Apnea, Obstructive
Evaluating the Diagnostic Efficacy of Smartwatch and Smartphone for Sleep Apnea
The purpose of this study is to evaluate the diagnostic value of smartphones and watches for OSA screening. The study will be conducted in individuals suspected of having OSA.
- Trial name
- NCT06573372
- Where
- China
- Volunteers
- 377 people
- Sponsor
- Peking University First Hospital
SHANK3 Haploinsufficiency, Phelan-McDermid Syndrome
Long-Term Follow-Up Study for RB001 Gene Therapy Study in Children With SHANK3-related Phelan McDermid Syndrome (PMS)
This is a long-term follow-up study of participants in the RB001-101 gene replacement therapy clinical trial for Children With SHANK3-related Phelan-McDermid Syndrome (PMS).
- Trial name
- RB001-101-LTFU (NCT07690527)
- Testing
- RB001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University First Hospital