Clinical trials: sponsored by Duke University
Malaria, Febrile Illness
Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Nigeria
Highly subsidized first-line antimalarials (artemisinin combination therapy or ACT) are available over the counter in the private retail sector in most malaria-endemic countries.
- Trial name
- NCT04428385
- Testing
- Testing incentive, Conditional artemisinin combination therapy subsidy
- Where
- Nigeria
- Volunteers
- 2,205 people
- Sponsor
- Duke University
Healthy
Improving Physician Vaccine Recommendation Using Social Norms, Trust, and Presumptive Language
This research examines vaccination recommendation perceptions and behaviors of physicians and advanced practice providers.
- Trial name
- NCT05957393
- Testing
- Quantity of vaccination recommendations, Quality of vaccination recommendations, Control
- Where
- 3 sites in United States, Brazil
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- Duke University
Inflammatory Response
Beef and Plant Burger Metabolomics Study
The purpose of this study is to determine the effects of meat on inflammatory and metabolite profiles in middle-aged individuals after an acute meal.
- Trial name
- NCT05690061
- Testing
- Grain-Fed Beef Hamburger, Grass-Fed Beef Hamburger, Impossible BurgerTM
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Utah State University
Well-Being, Psychological, Anxiety Depression
Personal Resilience Skills to Improve Surgery Training
The objective of the current study (PERSIST) is to 1) determine acceptability of an 8-session (16 week) group curriculum on personal resilience skills for residents in the Duke General Surgery Program, and 2) examine changes in…
- Trial name
- PERSIST (NCT06139614)
- Testing
- PERSIST
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Obesity, Cardiovascular Risk Factor
RESILIENCE: Personalizing Cardiovascular Health
Obesity is a rapidly growing epidemic that is associated with the development of cardiovascular disease (CVD). However, some individuals with obesity appear to be resistant to CVD, and other individuals demonstrate resilience to…
- Trial name
- RESILIENCE (NCT04551872)
- Testing
- Digital weight loss intervention
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Duke University
Malaria,Falciparum
Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)
This is a randomized, three-arm, open-label, clinical trial of malaria chemoprevention in children with sickle-cell anemia (SCA) at a single site in Homa Bay, Kenya.
- Trial name
- EPiTOMISE (NCT03178643)
- Testing
- Proguanil Oral Tablet, Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ), Dihydroartemisinin-Piperaquine (DP)
- Where
- Kenya
- Volunteers
- 246 people
- Sponsor
- Duke University
Preterm Infants
Very Low Birth Weight Preterm Infant Bundled Care in the NICU
The purpose of this study is to explore the impact of bundling nursing care activities on the overall health of Very Low Birthweight (VLBW) preterm infants who receive bundled care in a Level IV Neonatal Intensive Care Unit…
- Trial name
- NCT03370757
- Testing
- 3-hour bundled care, 6-hour bundled care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Duke University
Pediatric Obesity
Inspiratory Muscle Rehabilitation in Children With Obesity
This is a single-center, randomized, SHAM-controlled, parallel assignment, double-masked, interventional trial among children aged 8-17 years (not yet 18 years old) of age with obesity (n=30), recruited from the Duke Healthy…
- Trial name
- BREATHE Fit (NCT05412134)
- Testing
- Pro2 - 75% of participant's MIP, Pro2 - 15% of participant's MIP
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Duke University
Misophonia Treatment
Instructed Cognitive Reappraisal in Reducing Affective, Behavioral and Psychophysiological Symptoms of Misophonia
Misophonia is a disorder causing intense reactions to specific sounds, disrupting daily life. Current treatments lack evidence-based support.
- Trial name
- NCT06372405
- Testing
- Cognitive reappraisal, Schultz Autogenic Training
- Where
- Poland
- Volunteers
- 108 people
- Sponsor
- University of Warsaw, Poland
PTSD
The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
Some individuals who are exposed to traumatic events experience both psychological and cardiovascular changes that affect their health and well-being.
- Trial name
- ACCEPT (NCT02736929)
- Testing
- Cognitive Processing Therapy - Cognitive
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Duke University
Microbiome
Effect of Lactobacillus on the Microbiome of Household Contacts Exposed to COVID-19
The purpose of this study is to evaluate the effect of the probiotic Lactobacillus rhamnosus GG (LGG) and the effect of COVID-19 on the microbiome (the microorganisms that live in and on the human body) in exposed household…
- Trial name
- NCT04399252
- Testing
- Lactobacillus rhamnosus GG
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes Mellitus, Type 2
Empowering Patients With Chronic Disease Using Profiling and Targeted Feedbacks Delivered Through Wearable Device
Chronic diseases are the leading cause of deaths in Singapore. The rising prevalence in chronic diseases with age and Singapore's rapidly aging population calls for new models of care to effectively prevent the onset and delay…
- Trial name
- EMPOWER (NCT04518566)
- Testing
- Nudges
- Where
- 7 sites in Singapore
- Volunteers
- 1,000 people
- Sponsor
- Singapore General Hospital
Diabetes Mellitus, Type 2, Hypertension
EMPOWERing Patients With Chronic Diseases Through Smartphone App, Health Coaching and Shared Decision Making
Chronic diseases are the leading cause of deaths in Singapore. The rising prevalence in chronic diseases with age and Singapore's rapidly aging population calls for new models of care to effectively prevent the onset and delay…
- Trial name
- NCT05486390
- Testing
- Nudge, health coaching and shared decision-making
- Where
- 3 sites in Singapore
- Volunteers
- 320 people
- Sponsor
- Singapore General Hospital
Heart Block AV
Micra AV Tracking During Exercise Testing
The purpose of this study is to determine the effectiveness of the Micra AV 2.0 device during exercise or elevated heart rates. Participation in research studies is voluntary.
- Trial name
- NCT05966168
- Testing
- Medtronic Micra AV Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Infections
Cerebrospinal Fluid (CSF) Pharmacokinetics of Antimicrobials in Children
The purpose of this study is to learn more about antimicrobials, especially drug levels in the CSF that would normally be used in young children as part of standard care.
- Trial name
- NCT00991185
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Preterm Infants, Dolichocephaly
Treatment of Cranial Molding Deformities in Preterm Infants
The purpose of this study is to determine the effectiveness of the Tortle Midliner positioning system in prevention and/or treatment of dolichocephaly, which can develop in preterm infants during the hospital stay.
- Conditions
- Preterm Infants, Dolichocephaly, Positional Scaphocephaly
- Trial name
- NCT02366936
- Testing
- Tortle Midliner
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Hernia, Diaphragmatic
Early Childhood Follow-up of Congenital Diaphragmatic Hernia Survivors
The primary objective of this study is to determine the medical and neurodevelopmental outcomes of congenital diaphragmatic hernia (CDH) survivors at school-age (4-6 years) follow-up.
- Trial name
- CDH (NCT01029665)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Bronchopulmonary Dysplasia, Prematurity
Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia
The purpose of this study is to identify biological markers that might predict premature infants who are at a higher risk for developing BPD, and to correlate the presence of these markers with infant symptoms and lung function…
- Trial name
- GRP (NCT01748565)
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Duke University
Infection
Dynamics of the Microbiome in the Premature Infant
The purpose of the study is to describe the dynamics of the microbiome in the premature infant as a means to adapt the premature infant gut to affect better health outcomes.
- Trial name
- NCT02121938
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Gastroschisis
Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair
The purpose of this study is to determine which type of food results in a shorter hospital stay and better overall outcome for babies born with gastroschisis.
- Trial name
- NCT02575846
- Testing
- Enteral Intake - Human Milk, Enteral Intake - Formula
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University