Clinical trials: sponsored by Mayo Clinic
Human Microbiota
Implications of the Human Microbiota for Health and Disease
The purpose of this study is to advance the understanding of human health and disease as it relates to environmental factors that may affect intestinal and non-intestinal microbiota.
- Trial name
- NCT04203303
- Testing
- Observational
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Childhood Acute Lymphoblastic Leukemia, Childhood Lymphoblastic Lymphoma
Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study
This study evaluates the impact of calaspargase pegol (Cal-PEG) on the coagulation system in pediatric patients with acute lymphoblastic leukemia/lymphoma (ALL).
- Trial name
- NCT07071051
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Insomnia Chronic
Subjective Sleep Quality of Patients With Chronic Insomnia
The purpose of this study is to assess subjective sleep quality, diet quality, physical activity in patients with chronic insomnia before and after a brief lifestyle intervention during a traditional course of Cognitive…
- Trial name
- NCT06550388
- Testing
- Nutritional Education, Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia
This phase II trial studies how well pirtobrutinib and venetoclax work in treating patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.
- Trial name
- NCT05677919
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Osteoarthritis, OA
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
The purpose of this study is to determine the effectiveness and safety of autologous alpha-2 macroglobulin rich plasma (A2MRP) injections in the treatment of knee osteoarthritis (OA).
- Conditions
- Osteoarthritis, OA, Knee Osteoarthritis
- Trial name
- A2MRP (NCT06329492)
- Testing
- Autologous Alpha-2 Macroglobulin Rich Plasma (A2MRP)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux, Regurgitation
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Heartburn
- Trial name
- NCT05976165
- Testing
- Breath Testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Obesity
Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss
It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.
- Trial name
- NCT03238794
- Testing
- Roux-En-Y Gastric Bypass, Low-calorie Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Mild Autonomous Cortisol Secretion, Autonomous Cortisol Secretion (ACS)
Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)
The purpose of this study is to evaluate the safety and tolerability of 1 mg osilodrostat therapy in patients with mild autonomous cortisol secretion (MACS), and to determine the impact on 24h urine steroid metabolome and…
- Trial name
- NCT07104812
- Testing
- Osilodrostat 1 MG
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Goals
Shared Decision Making to Improve Goals of Care in the ED
This project will develop and refine a shared decision making (SDM) intervention (decision aid tool) to improve and normalize high quality end of life discussions in the Emergency Department (ED) setting.
- Trial name
- NCT03833622
- Testing
- Shared Decision Aid Assessment
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- Mayo Clinic
Human Papillomavirus Infection, Stage I Oropharyngeal Squamous Cell Carcinoma
Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer
This phase II trial studies how well radiation therapy and docetaxel work in treating patients with human papillomavirus (HPV)-related oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Conditions
- Human Papillomavirus Infection, Stage I Oropharyngeal Squamous Cell Carcinoma, Stage II Oropharyngeal Squamous Cell Carcinoma, Stage III Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT01932697
- Testing
- Docetaxel, Hyperfractionation, Intensity-Modulated Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Mayo Clinic
Spina Bifida, Congenital Diaphragmatic Hernia
Maternal-fetal Immune Responses to Fetal Surgery
Performing surgery in utero on fetuses with certain birth defects has led to significant improvements in outcomes after birth; however, many of these infants are born preterm which can decrease the effectiveness of these…
- Conditions
- Spina Bifida, Congenital Diaphragmatic Hernia, Lower Urinary Tract Obstructive Syndrome, Myelomeningocele
- Trial name
- NCT04484441
- Testing
- Blood and placenta specimen collection.
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Cirrhosis, Liver, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
ALTA TIPS: A 5-year Longitudinal Observational Study of Patients Undergoing TIPS Placement
ALTA is a multicenter consortium focused on the management of portal hypertension. ALTA TIPS is a longitudinal observational study of patients who are undergoing transjugular intrahepatic portosystemic shunt (TIPS) placement.
- Trial name
- NCT03973372
- Where
- 14 sites in United States
- Volunteers
- 852 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy Adult Participants
Acute Effects of Alpha-glycerylphosphorylcholine (A-GPC) on Lower Body Muscular Performance.
The purpose of the present study was to examine the effectiveness of acute A-GPC supplementation on upper and lower body muscular strength, endurance, power, and global levels of activation.
- Trial name
- A-GPC (NCT07397273)
- Testing
- L-Alpha glycerylphosphorylcholine, Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northern Illinois University
Crohn's Disease, Intestinal Fibrosis
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
This study is a prospective, case-control study evaluating whether the PET radiotracer 68Ga-FAPI-46 can detect fibrostenosing Crohn's disease in the small bowel.
- Conditions
- Crohn's Disease, Intestinal Fibrosis, Inflamatory Bowel Disease, Intestinal Strictures Related to Crohn´s Disease
- Trial name
- FAPI-PETCD (NCT07273188)
- Testing
- Ga68-FAPI-46
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Genetic Testing
Prospective Registry of Multiplex Testing (PROMPT)
This study is being done to learn more about how changes in certain genes may be linked to cancer. Some people with cancer got their disease because they inherited an abnormal (mutated) gene.
- Trial name
- NCT02665195
- Testing
- saliva specimen, questionnaire
- Where
- 10 sites in United States
- Volunteers
- 689 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hearing Loss
AI Noise Reduction in Phonak Hearing Aids
The purpose of this study is to determine if artificial intelligence- based noise reduction can offer objective improvement in hearing and speech perception for hearing impaired patients.
- Trial name
- NCT06743295
- Testing
- DEEPSONIC™ Deep Sound Optimized Neural Integrated Chip Artificial intelligence-based noise reduction
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Hematopoietic and Lymphatic System Neoplasm, Acute Lymphobkastic Leukemia
A Study to Determine Number of Patients Who Develop High Ammonia Levels After Receiving Recombinant Erwinia Asparaginase
This study evaluates the incidence of symptomatic hyperammonemia (high ammonia levels) in patients being treated with recombinant Erwinia asparaginase.
- Trial name
- NCT06600659
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Sepsis, Infection
BLOOM: Pragmatic Feasibility Trial
The goal of this study is to compare two different ways of dosing cefepime, an antibiotic for very sick patients - the usual approach to dosing or a new dosing method.
- Trial name
- NCT07287332
- Testing
- Up-front individualized dosing algorithm, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Non-traumatic Hemispheric Brain Lesions
A Study to Detect Progression of Mass Effect From Unilateral Brain Lesions
The purpose of this research is to gather information on the safety and effectiveness of the Brain4Care device for measuring intracranial pressure without invasive procedures.
- Trial name
- NCT04745884
- Testing
- Non-invasive bilateral monitoring of ICP waveform
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Arthropathy of Knee
How Many Dexamethasone Doses Should Be Given Perioperatively?
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea…
- Trial name
- DEXA_PERIOP (NCT06715709)
- Testing
- Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Mayo Clinic
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