Clinical trials: sponsored by University of Chicago
Stimulant Use, MDMA ('Ecstasy')
Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function
To study the effects of MDMA, compared to a prototypical stimulant, on social motivation, social ability, and neural indices of social function in healthy volunteers
- Conditions
- Stimulant Use, MDMA ('Ecstasy'), Social Behavior, Motivation
- Trial name
- MASM (NCT05379959)
- Testing
- MDMA, Methamphetamine
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy, Mood
Brain Function and EEG
In this project, we will examine effects of MA on reward function using electroencephalograms (EEG), which will complement our ongoing study with MA and fMRI.
- Trial name
- DEG (NCT05003076)
- Testing
- Methamphetamine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
HIV Infections
Papuan Indigenous Model of Male Circumcision
The purpose of the study is: AIM 1: To engage Papuan community members to explore acceptability, barriers and facilitators for introducing a school-based age and culturally appropriate, comprehensive VMMC intervention to reduce…
- Trial name
- NCT06212531
- Testing
- Medical male circumcision using standard surgical technique.
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV
Advanced HIV Prevention (PrEP Chicago)
This study will evaluate the feasibility of a network intervention to train individuals to disseminate PrEP information and motivate initial PrEP interest and knowledge of PrEP in their social networks.
- Trial name
- NCT02896699
- Testing
- PrEP Intervention Group, Control Group
- Where
- United States
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Fertility Issues, Disclosure
Feasibility Trial of the TELL Tool Intervention
A radical paradigm shift is taking place where technology, notably the explosion in easy accessible direct-to-consumer genetic testing (e.g., 23andMe) and a high consumer interest in genealogy (e.g., Ancestry.com), has hijacked…
- Conditions
- Fertility Issues, Disclosure, Parenting
- Trial name
- NCT04841967
- Testing
- TELL Tool Intervention, eBook Attention Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy, MDMA ('Ecstasy')
Effect of Stimulant Drugs on Social Perception
The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA).
- Trial name
- ESP (NCT03790618)
- Testing
- 3,4-Methylenedioxymethamphetamine, methamphetamine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Mesothelioma, Peritoneal Mesothelioma
A Study of Immunotherapy Drugs Nivolumab and Ipilimumab in Patients w/Resectable Malignant Peritoneal Mesothelioma
This study is for individuals who have peritoneal mesothelioma, a cancer of the lining of your abdominal wall and organs (the peritoneum).
- Trial name
- NCT05041062
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Chicago
Perianal Wart
Comparing CO2 Laser and Electrosurgical Treatments for Perianal Condyloma
Perianal condyloma are skin- colored and fleshy lesions caused by various variants of Human Papilloma Virus (HPV), most commonly 6 and 11.
- Trial name
- NCT06166290
- Testing
- CO2 LASER Vaporisation, Electrosurgical Fulguration
- Volunteers
- 110 people
- Sponsor
- University of Illinois Chicago
Sickle Cell Disease, Kidney Diseases, Chronic
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia
This is a multicenter prospective, longitudinal cohort study which will evaluate the predictive capacity of machine learning (ML) models for progression of CKD in eligible patients for a minimum of 12 months and potentially for…
- Trial name
- PREMIER (NCT05214105)
- Testing
- Biospecimen/DNA collection and analysis
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Tennessee
Breast Neoplasms, Breast Diseases
Abbreviated MRI Protocol: Initial Experience With Dotarem® (Gadoterate Meglumine)
Standard breast MRI studies often have lengthy protocols that make them inherently expensive and time-consuming. Several studies of the use of abbreviated MRI protocols have shown that the shorter protocols have diagnostic…
- Conditions
- Breast Neoplasms, Breast Diseases, Breast Fibroadenoma, Breast Cancer
- Trial name
- NCT04341129
- Testing
- Abbreviated MRI protocol: initial experience with Dotarem® (Gadoterate Meglumine)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Head and Neck Cancer
Phase II Trial of Pemetrexed-Based Induction Chemotherapy Followed by Concomitant Chemoradiotherapy in Previously Irradiated Head and Neck Cancer Patients
The purpose of this study is to determine 1-year survival of previously irradiated Head and Neck cancer (HNC) patients with loco-regional recurrent disease treated with induction chemotherapy with pemetrexed and gemcitabine…
- Trial name
- NCT01172470
- Testing
- Gemcitabine, Pemetrexed, Carboplatin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Menopause, Hot Flashes
Caria: Digital Intervention for Menopause Symptom
Menopause is the time of life when menstrual cycles cease. Women typically spend 30-40% of their lives in menopause. Individual experiences of menopause vary and although some women do not experience any significant symptoms…
- Trial name
- NCT04882982
- Testing
- Caria app, Menopause Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Illinois Chicago
Head and Neck Cancer
Organ Preservation in the Multispeciality Therapy of Stage II-IV Locally Advanced Head and Neck Cancer
This protocol was opened to collect long term survival information on subjects enrolled in a previous study which evaluated the impact of neoadjuvant chemotherapy and concomitant chemoradiotherapy with organ preserving optional…
- Trial name
- NCT01187472
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Healthy
Mood Effects of Serotonin Agonists Extended
In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.
- Trial name
- MESA-E (NCT03934710)
- Testing
- Serotonin agonist - 13ug, Serotonin agonist - 26ug
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Head and Neck Cancer
A Phase II Study of 250-mg ZD1839 Monotherapy in Recurrent or Metastatic or Both Recurrent and Metastatic Squamous Cell Carcinoma
The purpose of this study is to find out what effects (good and bad) ZD1839 has on one's squamous cell head and neck cancer. The research is being done because currently no effective treatment exists for metastatic (spread of…
- Trial name
- NCT01185158
- Testing
- ZD1839 (IRESSA)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Chicago
Metastatic Renal Cell Carcinoma
MRI Study of BAY 43-9006 in Metastatic Renal Cell Carcinoma
The purpose of this study is to determine maximum tumor shrinkage, time to progression, survival, drug concentration, and degree of skin toxicity.
- Trial name
- MRI (NCT00606866)
- Testing
- Sorafenib
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Chicago
Prostate Cancer
A Randomized Study of Testosterone Replacement in Patients With Low Risk Hormone Refractory Prostate Cancer
The purpose of this study is to see how safe Androderm® (the study drug) is at three different doses in subjects with early hormone refractory prostate cancer.
- Trial name
- NCT01187485
- Testing
- Androderm® 2.5mg, Androderm® 5.0mg, Androderm® 7.5mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Atopic Dermatitis
Brief Cognitive Behavioral Therapy to Treat Itch Rumination "Itch CBT" in Eczema
The main purpose of this study is to adapt cognitive behavior therapy (CBT) to improve itch in children with eczema.
- Trial name
- NCT04486742
- Testing
- Itch CBT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Tolerance, Adolescent Behavior
Age-Related Effects of THC
Increased accessibility to cannabis and its primary psychoactive constituent THC has raised public health concerns. One major concern surrounds the potential risks associated with acute THC intoxication and who might be most at…
- Conditions
- Tolerance, Adolescent Behavior, THC
- Trial name
- ART (NCT04294966)
- Testing
- Dextrose, Dronabinol
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Supply and Demand of Early Care and Education in the US
National Survey of Early Care and Education
The primary purpose of the National Survey of Early Care and Education (NSECE) was to provide a comprehensive snapshot of both the availability and utilization of early care and education in the United States.
- Trial name
- NSECE (NCT02188329)
- Where
- United States
- Volunteers
- 31,436 people
- Sponsor
- National Opinion Research Center
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