Clinical trials: sponsored by Ohio State University Comprehensive Cancer Center
Leukemia, Other
Hairy Cell Leukemia Patient Data Registry
The overall objective is to develop a clinical data registry that can be used to facilitate research with the ultimate goal of reducing the morbidity and/or mortality and improving the quality of life of patients diagnosed or…
- Trial name
- HCL-PDR (NCT02560883)
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma
This phase I trial tests the side effects and best dose of TGFbi natural killer (NK) cells (TiNK) when given together with isatuximab for the treatment of patients with multiple myeloma that has come back after a period of…
- Trial name
- NCT06203912
- Testing
- Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Cyclophosphamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Elvira Umyarova
Lung Carcinoma
Endobronchial Ultrasound-Guided Transbronchial Needle-Aspiration With Suction in Obtaining Samples From Patients With Suspected Nodal Metastatic Lung Cancer
This trial studies how well endobronchial ultrasound-guided transbronchial needle-aspiration (EBUS-TBNA) with suction works in obtaining samples from patients with suspected lung cancer that has spread to the nodal.
- Trial name
- EBUS-Suction (NCT04116970)
- Testing
- Bronchoscopy, Ultrasound-Guided Transbronchial Needle Aspiration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Locally Advanced Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer
This phase I trial finds out the best dose, possible benefits and/or side effects of papaverine when given together with chemoradiation intreating patients with stage II-III non-small cell lung cancer.
- Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8
- Trial name
- NCT05136846
- Testing
- Carboplatin, Durvalumab, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking-Related Carcinoma
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
This clinical trial compares the use of oral nicotine pouches to nicotine replacement therapy, consisting of nicotine patches and lozenges, to reduce cigarette use in smokers living in rural Appalachia.
- Trial name
- ARISE (NCT06763536)
- Testing
- Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer
This clinical trial aims to see if patients with triple negative breast cancer can complete a biobehavioral stress reduction program that also addresses health related social needs (e.g., utilities, transportation, etc.).
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma
- Trial name
- NCT05677802
- Testing
- Biospecimen Collection, Medical Chart Review, Stress Management Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco-Related Carcinoma, Addiction
Comparative Evaluation of Nicotine Analogs
This phase I trial compares electronic cigarette (EC) user preferences and smoking behaviors of nicotine analogs to nicotine to improve the understanding of nicotine analog addictiveness.
- Trial name
- CENA (NCT07585006)
- Testing
- Biospecimen Collection, Nicotine, 6-Methyl Nicotine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma
Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
This phase II trial studies the effect of cemiplimab in combination with low-dose paclitaxel and carboplatin in treating patients with squamous cell carcinoma of the head and neck that has come back (recurrent) or spread to other…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT04862650
- Testing
- Carboplatin, Cemiplimab, Paclitaxel
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Marcelo Bonomi
Clinical Stage II Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study
This study evaluates the time spent on obtaining insurance approval and drugs, means of insurance coverage, out-of-pocket costs for patients, and the surgical outcomes after neoadjuvant treatment is completed in skin cancer…
- Conditions
- Clinical Stage II Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8, Locally Advanced Basal Cell Carcinoma
- Trial name
- NCT07215988
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer, HER2-positive Breast Cancer
Neoadjuvant Complete Response Customized Treatment Approach for Definitive Management of Breast Cancer
This study will evaluate the efficacy and non-inferiority of a non-surgical approach for the treatment of patients with locally advanced breast cancer.
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Triple Negative Breast Cancer
- Trial name
- NoCUT-BC (NCT07217990)
- Testing
- Neoadjuvant Chemotherapy, Radiation Therapy, MRI
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Acute Myeloid Leukemia
IDH Targeted/Non- Targeted vs Non-targeted/IDH-targeted Approaches in the Treatment of Newly Diagnosed IDH Mutated AML Patients Not Candidates for Intensive Induction Therapy (I- DATA Study)
This phase II study compares the order of treatment with ivosidenib or enasidenib and azacitidine plus venetoclax in treating older patients with acute myeloid leukemia with genetic changes in the IDH1 or IDH2 genes (IDH…
- Trial name
- NCT05401097
- Testing
- Azacitidine, Biopsy, Enasidenib
- Where
- 4 sites in United States
- Volunteers
- 125 people
- Sponsor
- Alice Mims
Cigarette Smoker, Current Smoker
Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer
This randomized clinical trial studies the Beating Lung Cancer in Ohio protocol in improving survival in patients with stage IV non-small cell lung cancer.
- Conditions
- Cigarette Smoker, Current Smoker, Lung Adenocarcinoma, Squamous Cell Lung Carcinoma
- Trial name
- BLCIO (NCT03199651)
- Testing
- Best Practice, Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 3,584 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Carcinoma, Obesity-Related Malignant Neoplasm
A Dietary Intervention (Soy Soft Pretzels) for Reducing Chronic Inflammation in Obese Individuals
This clinical trial compares the effects of soy soft pretzels versus wheat pretzels on inflammatory markers in individuals with obesity.
- Trial name
- NCT07650409
- Testing
- Biospecimen Collection, Dietary Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Chronic Lymphocytic Leukemia, Refractory Chronic Lymphocytic Leukemia
Bcl-2 Inhibitor GDC-0199 in Combination With Obinutuzumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or Previously Untreated Chronic Lymphocytic Leukemia
This phase Ib/II trial studies the best dose and safety of Bcl-2 inhibitor GDC-0199 in combination with obinutuzumab and ibrutinib and to see how well they work in treating patients with chronic lymphocytic leukemia that has…
- Trial name
- NCT02427451
- Testing
- Bcl-2 Inhibitor GDC-0199, Obinutuzumab, Ibrutinib
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Kerry Rogers
Pancreatic Carcinoma, Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type
Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer
This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer.
- Trial name
- NCT03711890
- Testing
- Optical Coherence Tomography, Therapeutic Conventional Surgery, Laboratory Evaluation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Chronic Lymphocytic Leukemia
Daratumumab and Ibrutinib in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia
This phase Ib trials studies the side effects of daratumumab and ibrutinib and how well they work in treating patients with symptomatic chronic lymphocytic leukemia.
- Trial name
- NCT03447808
- Testing
- Daratumumab, Ibrutinib, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jennifer Woyach
Cervical Carcinoma, Human Papillomavirus-Related Malignant Neoplasm
I Vaccinate: Testing Multi-Level Interventions to Improve HPV Vaccination
This trial studies how well a multi-level health system-based intervention works in improving human papillomavirus (HPV) vaccine initiation and completion among children in health systems in four Appalachian states.
- Trial name
- IVaccinate (NCT04452526)
- Testing
- Best Practice, Educational Intervention, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Abuse Tobacco, Exposure
Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study
This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.
- Trial name
- ICE (NCT06208202)
- Testing
- Behavioral Intervention, Biospecimen Collection, Survey Administration
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Healthy Volunteers
Black Raspberry Confection in Preventing Oral Cancer in Healthy Volunteers
This clinical trial studies black raspberry confection in preventing oral cancer in healthy volunteers. Black raspberry contains ingredients that may prevent or slow the growth of certain cancers.
- Trial name
- NCT01961869
- Testing
- Fast release BRB confection, Intermed release BRB confection, Prolong release BRB confection
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia
Impact of Dietary Inflammatory Potential on Breast Cancer Risk
This study evaluates the association of dietary inflammatory potential with breast cancer risk. Information collected in this study may help doctors to identify modifiable risk factors, screen high risk patients early, improve…
- Conditions
- Breast Atypical Ductal Hyperplasia, Breast Atypical Lobular Hyperplasia, Breast Carcinoma, Breast Lobular Carcinoma In Situ
- Trial name
- NCT05178498
- Testing
- Follow-Up, Physical Examination, Questionnaire Administration
- Where
- United States
- Volunteers
- 960 people
- Sponsor
- Ohio State University Comprehensive Cancer Center