Clinical trials: sponsored by Unity Health Toronto
Schizophrenia, Bipolar Disorder
Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities (AFTERMATH)
The COVID-19 pandemic significantly impacted primary care across Canada. Inequities in prevention activities and chronic disease management likely increased but the extent is unknown.
- Trial name
- AFTERMATH (NCT05823805)
- Testing
- Community Health Worker
- Volunteers
- 520 people
- Sponsor
- Unity Health Toronto
Covid19
The Canadian COVID-19 Prospective Cohort Study
The CANCOV study will be the first Canadian study to provide a comprehensive evaluation of early, and 1-year, outcomes of outpatient and hospitalized COVID-19 survivors and their family caregivers, their varied trajectories and…
- Trial name
- CANCOV (NCT05125510)
- Where
- 14 sites in Canada
- Volunteers
- 2,176 people
- Sponsor
- University Health Network, Toronto
Perinatal Depression
Scaling Up Maternal Mental Healthcare by Increasing Access to Treatment (SUMMIT)
SUMMIT's (Scaling Up Maternal Mental health care by Increasing access to Treatment) overarching goal is to examine the scalability and patient-centered provision of brief, evidence-based psychological treatments for perinatal…
- Trial name
- SUMMIT (NCT04153864)
- Testing
- Brief Behavioral Activation Treatment
- Where
- 5 sites in United States, Canada
- Volunteers
- 1,230 people
- Sponsor
- Mount Sinai Hospital, Canada
Bleeding Disorder
Early Genomic Testing for Inherited Bleeding Disorders
The investigators aim to test the introduction of genomic testing early in the diagnostic pathway for inherited bleeding disorders in patients who have not received a diagnosis after first-line testing.
- Trial name
- GT4BD (NCT06736158)
- Testing
- Genetic testing for inherited bleeding disorders
- Where
- 3 sites in Canada
- Volunteers
- 212 people
- Sponsor
- Queen's University
MCI, Amnestic Mild Cognitive Disorder
Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI)
Over 50 million people worldwide are currently living with dementia-a number projected to rise to 152 million by 2050. Mitochondrial dysfunction in the brains of individuals with Mild Cognitive Impairment (MCI) and Alzheimer's…
- Trial name
- NCT05563298
- Testing
- Neuro RX Gamma device
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Bronchiolitis
Low-value Care, and Variation in Practice for Children Hospitalized With Bronchiolitis
Low-value care is defined as the use of a health service, such as diagnostics and treatments, for which the harms or costs outweigh the benefits.
- Trial name
- CareBEST (NCT06506474)
- Testing
- Provision of any of six different low-value health services for treatment of bronchiolitis
- Where
- 15 sites in Canada
- Volunteers
- 3,000 people
- Sponsor
- St. Justine's Hospital
Autism Spectrum Disorders
A Pilot Study of Riluzole Versus Placebo in the Treatment of Children and Adolescents With ASD
This study will examine the potential efficacy and safety of riluzole for core and associated symptom domains of autism and will explore biological markers of safety and treatment response.
- Trial name
- RILISE (NCT01661855)
- Testing
- Riluzole
- Where
- 3 sites in Canada
- Volunteers
- 58 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
Arbaclofen vs. Placebo in the Treatment of Children and Adolescents With ASD (ARBA)
This study will examine the safety and efficacy of arbaclofen vs. placebo on social function in children and adolescents with Autism Spectrum Disorder (ASD).
- Trial name
- ARBA (NCT03887676)
- Testing
- Arbaclofen
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders
There is substantial evidence from animal model and healthy control data, that oxytocin is involved in the modulation of social cognition.
- Trial name
- INOXT (NCT01788072)
- Testing
- Intranasal Oxytocin
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorders
Tideglusib vs. Placebo in the Treatment of Adolescents With Autism Spectrum Disorders
This study will examine the safety and efficacy of tideglusib vs. placebo for the treatment of core symptom domains in adolescents with Autism Spectrum Disorders
- Trial name
- TIDE (NCT02586935)
- Testing
- Tideglusib
- Where
- 3 sites in Canada
- Volunteers
- 83 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
HIV Infections, Syphilis Infection
Multiplo Near Patient Non-HCP Study
To help reach the undiagnosed living with HIV and/or syphilis in Canada, point-of-care (POC) tests for HIV and Syphilis may have substantial utility for increased identification of infected individuals through their relative ease…
- Trial name
- NCT06463314
- Testing
- Multiplo TP/HIV Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Neuroinflammatory Diseases, Multiple Sclerosis
FIT-ATOMIC Exercise Feasibility Trial
This multi-center, randomized controlled feasibility trial will assess a 20-week home-based exercise intervention in youth with Multiple Sclerosis (MS).
- Trial name
- FIT-ATOMIC (NCT06870968)
- Testing
- Exercise Training, Mobility and Flexibility Training
- Where
- 4 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Mechanical Ventilator Weaning, Respiratory Muscle Training
Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training
Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure.
- Trial name
- FLEX (NCT05710432)
- Testing
- Quasi-Isometric Neck Flexion, Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Acute Hypercapnic Respiratory Failure
The Simplify Project
The high frequency of unplanned hospital visits of patients with chronic hypercapnic respiratory failure (e.g., chronic obstructive pulmonary disease, obesity-related hypoventilation) constitutes a major public health problem.
- Trial name
- SIMPLIFY (NCT05011877)
- Testing
- High-flow nasal cannula therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Acute Hypoxemic Respiratory Failure
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator.
- Trial name
- PUMA (NCT06494085)
- Testing
- Measuring Respiratory Mechanics, Randomized Pressure Support
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Trauma Chest, Mechanical Ventilation
Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study
This is a single-center, prospective, physiological study. The study will enroll the traumatic lung injury patient who has at least 2 rib fractures requiring mechanical ventilation being on partially assisted breathing mode and…
- Trial name
- VICTORY (NCT06196125)
- Testing
- Four body positions
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Respiratory Support
The ACCESSIT Study
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
- Trial name
- ACCESSIT (NCT05207046)
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto