Clinical trials: not yet recruiting
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Participants
A Trial to Assess the Relative Bioavailability of Different Subcutaneous Formulations of AZD9550 and AZD6234
This study in healthy volunteers aims to compare blood levels and side effects after administration of different formulations of two test medicines, AZD9550 and AZD6234.
- Trial name
- NCT07911514
- Testing
- AZD9550 solution for injection, AZD6234 solution for injection, Formulation 1 solution for injection
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity (Disorder), Inflammation
Effects of Taurine Supplementation and Morning or Evening High-intensity Exercise on Circadian Clock Genes and Inflammatory Parameters in Adult Women With Obesity
The goal of this clinical trial is to evaluate whether taurine supplementation, alone or combined with high-intensity interval training (HIIT) performed in morning or evening, affects circadian clock gene expression and…
- Trial name
- NCT07910747
- Testing
- Taurine supplementation, High-intensity interval training (HIIT)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Acute Myeloid Leukemia, High-risk Myelodysplastic Syndrome
ATRN-119 in Combination With Decitabine in Patients With TP53-Mutated AML or Higher-Risk MDS
This single-center, open-label, phase I study will evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antileukemic activity of ATRN-119 (mosipasertib) alone and in combination with decitabine…
- Trial name
- NCT07617363
- Testing
- ATRN-119, Decitabine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Femur Neck Fracture, Hip Fractures
Lumbar Erector Spinae Plane Block Versus PENG Block for Hip Fracture Surgery
The purpose of this clinical trial is to compare two different nerve block techniques-the Pericapsular Nerve Group (PENG) block and the Lumbar Erector Spinae Plane Block (L-ESPB)-for managing pain after hip fracture surgery in…
- Conditions
- Femur Neck Fracture, Hip Fractures, Postoperative Pain
- Trial name
- NCT07910487
- Testing
- Pericapsular Nerve Group Block, Lumbar Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Beni-Suef University
Biliary Tract Cancer (BTC)
Prospective AI-Assisted Screening of Biliary Tract Cancer Using Non-Contrast CT
Biliary tract cancer is a group of malignant tumors involving the intrahepatic bile ducts, extrahepatic bile ducts, and gallbladder.
- Trial name
- BTC-NCCT-AI (NCT07911397)
- Testing
- AI-Assisted Biliary Tract Cancer Screening Using NCCT
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Chronic Granulomatous Disease
Lentiviral Gene Therapy for CGD
This is a Phase I/II clinical trial of gene therapy for treating Chronic Granulomatous Disease using a high-safety, high-efficiency, self-inactivating lentiviral vector TYF to functionally correct the defective gene.
- Trial name
- NCT03645486
- Testing
- Infusion of lentiviral TYF-CGD-modified autologous stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Spinal Cord Injury
Influence of Transcranial Electrical Stimulation on Arm and Hand Function After Cervical Spinal Cord Injury
The goal of this pilot study is to find out how four different types of transcranial electrical stimulation (tES) affect brain activity, the process of acquiring new skills (also called motor learning), and hand function after…
- Trial name
- NCT07909317
- Testing
- transcranial direct current stimulation (tDCS) + FTP, transcranial pulsed current stimulation (tPCS) + FTP, transcranial random noise stimulation (tRNS) + FTP
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shepherd Center, Atlanta GA
Lung Cancer Screening
C-Raven LDCT: Lung Cancer Screening Intervention
This study is a three-arm, randomized controlled pilot of a lung cancer screening intervention. The investigators will recruit participants ages 50-80 who are likely to meet lung cancer screening guidelines.
- Trial name
- C-Raven LDCT (NCT07819318)
- Testing
- Video/Brochure, Video/Brochure/Follow-up Call
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Multiple Myeloma, Plasmacytoma
Frontline Combination CAR-T Cell Therapy for Multiple Myeloma or Plasmacytoma
The aim of this clinical trial is to assess the feasibility, safety, and efficacy of CAR-T cell therapy targeting multiple cancer cell antigens in high-risk multiple myeloma or plasmacytoma as part of a frontline treatment…
- Trial name
- NCT06429150
- Testing
- CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Solid Tumor
Comparing Radiotherapy Dose Strategies for Symptom Relief in Large Solid Tumors
This study will compare three ways of giving radiotherapy to relieve symptoms caused by a large solid tumor. Radiotherapy uses radiation to treat cancer.
- Trial name
- SCALE-LRT (NCT07908914)
- Testing
- Homogeneous External-Beam Radiotherapy, 20 Gy in Five Fractions, Homogeneous External-Beam Radiotherapy, 25 Gy in Five Fractions, LATTICE Radiotherapy, 20 Gy With a Simultaneous Integrated Boost to 66.7 Gy in Five Fractions
- Where
- Poland
- Volunteers
- 426 people
- Sponsor
- Affidea Nu-med Center of Oncological DIagnostics and Therapy
Gastroenteropancreatic Neuroendocrine Tumors
TRINITY TRIAL; Trial Of PRRT Plus CAPTEM Vs CAPTEM Alone In Well Differentiated GEP NETS
The goal of this Phase III randomized controlled, open-label clinical trial is to evaluate the efficacy and safety of adding peptide receptor radionuclide therapy (PRRT) with Lutetium-177 DOTATATE to standard-of-care chemotherapy…
- Trial name
- TRINITY (NCT07910760)
- Testing
- Capecitabine, Temozolomide (TMZ), Lutetium Lu 177 Dotatate
- Volunteers
- 123 people
- Sponsor
- Tata Memorial Hospital
Anxiety, Cesarean Section
Virtual Reality for Anxiety and Birth Satisfaction During Elective Cesarean Section
This study will examine whether virtual reality during planned cesarean birth reduces women's anxiety and improves their satisfaction with the birth experience.
- Conditions
- Anxiety, Cesarean Section, Birth Satisfaction
- Trial name
- NCT07908771
- Testing
- Virtual Reality Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Tarsus University
Postoperative Pain After Breast Augmentation Surgery, Postoperative Analgesia
Effect of Adding Ultrasound-Guided PECS II Block to Standard Multimodal Analgesia in Breast Augmentation Surgery
This randomized, controlled clinical study will evaluate the effect of an ultrasound-guided PECS II block on postoperative pain control in patients undergoing elective augmentation mammoplasty.
- Trial name
- NCT07879053
- Testing
- Ultrasound-Guided PECS II Block, Standard multimodal analgesia
- Volunteers
- 50 people
- Sponsor
- Ergun Gunduz
Idiopathic Pulmonary Fibrosis (IPF)
A Phase 2 Study of HB0056 in Patients With Idiopathic Pulmonary Fibrosis
This trial is a 58 week randomized, double-blind, placebo-controlled, parallel-group, multicenter trial in which the efficacy, safety, and pharmacokinetics of HB0056, either on top of stable IPF therapy or as monotherapy, are…
- Trial name
- NCT07909655
- Testing
- HB0056
- Where
- 2 sites in China
- Volunteers
- 75 people
- Sponsor
- Shanghai Huaota Biopharmaceutical Co., Ltd.
Cancer Disease
GD2/CD70 Bi-specific CAR-T Cell Therapy
The purpose of this study is to assess the feasibility, safety and efficacy of GD2/CD70 bi-specific CAR-T cell therapy in patients with GD2 and/or CD70 positive tumor.
- Trial name
- NCT05438368
- Testing
- bi-4SCAR GD2/CD70 T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Hemorrhoidal Disease
A Three-Arm, Randomized, Placebo-Controlled, Double-Blind Phase 2 Study to Evaluate the Safety and Efficacy of Two Dosage Regimens of a Novel Hydrocortisone Acetate Suppository Formulation Administered With a Proprietary Suppository Applicator in Subjects With Hemorrhoidal Disease
The goal of this clinical trial is to evaluate the efficacy of two dosage regimens of hydrocortisone acetate suppository administered with a proprietary suppository applicator (Study Drug) compared to placebo in the treatment of…
- Trial name
- NCT07909291
- Testing
- hydrocortisone acetate 50 mg, hydrocortisone acetate 75 mg, proprietary suppository applicator
- Volunteers
- 78 people
- Sponsor
- Cristcot LLC
Kidney Stones, Urolithiasis, Hypocitraturia, Pain, Postoperative
Intertransverse Process Block Versus Erector Spinae Plane Block for Postoperative Analgesia After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is the preferred minimally invasive procedure for renal stones larger than 2 cm, staghorn calculi and complex stone burdens, but it is frequently associated with moderate-to-severe…
- Trial name
- NCT07908992
- Testing
- Ultrasound-guided intertransverse process block, Ultrasound-guided erector spinae plane block
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
High-altitude Pulmonary Edema
High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in Children High-altitude Pulmonary Edema
This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in children with High-Altitude Pulmonary Edema (HAPE).
- Trial name
- NCT07910357
- Testing
- High-flow Nasal Cannula Oxygen Therapy (HFNC)
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Ye Fan
Acute Respiratory Tract Infection
HAIQU (Hospital AIr QUality)
The purpose of this research is to assess whether integration of an aerosol biosensor and air quality risk assessment software that integrates into a building management system will improve indoor air quality metrics in hospital…
- Trial name
- HAIQU (NCT07670117)
- Testing
- Self-swab test
- Where
- 3 sites in United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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