Clinical trials: sponsored by Copenhagen University Hospital, Rigshospitalet
Gastrointestinal Bleeding, Stress Ulcers
Stress Ulcer Prophylaxis in the Intensive Care Unit
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported.
- Trial name
- SUP-ICU (NCT02467621)
- Testing
- Pantoprazole, Saline (0.9%)
- Where
- 33 sites in Denmark, Finland and 4 more
- Volunteers
- 3,350 people
- Sponsor
- Dr. Morten Hylander Møller
Trauma, Trauma Injury
Hypoxemia in the First 24 Hours After Trauma - an Observational Study
The goal of this observational study is to investigate the occurrence of hypoxemia (an abnormally low concentration of oxygen in the blood) in trauma patients within the first 24 hours of hospital admission following arrival to a…
- Conditions
- Trauma, Trauma Injury, Hypoxemia, Hypoxia
- Trial name
- HYPOX24 (NCT06256692)
- Testing
- Pulse oximeter
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Kidney Failure, Chronic, Peritoneal Dialysis-associated Peritonitis
Prevention of Peritonitis in Peritoneal Dialysis
BACKGROUND: Peritonitis remains a significant problem in peritoneal dialysis (PD). It is the leading cause of technique failure, and contributes to mortality. The incidence is highest during the first year of treatment.
- Conditions
- Kidney Failure, Chronic, Peritoneal Dialysis-associated Peritonitis, Dialysis Capd Infection
- Trial name
- PEPS (NCT01293799)
- Testing
- Retraining
- Where
- Sweden
- Volunteers
- 713 people
- Sponsor
- Sahlgrenska University Hospital
Septic Shock
The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
The purpose of this trial is to assess patient important benefits and harms of IV fluid restriction vs. standard care fluid therapy in patients with septic shock.
- Trial name
- CLASSIC (NCT03668236)
- Testing
- Isotonic crystalloids
- Where
- 31 sites in Belgium, Czechia and 6 more
- Volunteers
- 1,554 people
- Sponsor
- Anders Perner, MD, PhD
Xerostomia
Mesenchymal Stemcells for Radiation Induced Xerostomia
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants.
- Trial name
- MESRIX (NCT02513238)
- Testing
- Mesenchymal stem cell, Isotonic NaCl
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-small Cell Lung Cancer
Navelbine And Radiotherapy in Locally Advanced Lung Cancer
This study is an open label randomized multi-centre phase II trial in patients with inoperable locally advanced stage IIB-IIIB Non Small Cell Lung Cancer who fulfils the general criteria for curatively intended irradiation.
- Trial name
- NARLAL (NCT00887783)
- Testing
- Navelbine, 66 Gy/33F, 60 Gy/30F
- Where
- 6 sites in Denmark
- Volunteers
- 117 people
- Sponsor
- Odense University Hospital
Complication, Postoperative
Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period
Background: Several randomized clinical trials have shown beneficial effects of pre-operative glucocorticoids on post-operative complications.
- Trial name
- STEREO (NCT03403517)
- Testing
- Methylprednisolone, Dexamethasone
- Where
- Denmark
- Volunteers
- 174 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-small Cell Lung Cancer
Tarceva And Radiotherapy in Locally Advanced Lung Cancer Non-small Cell Lung Cancer
The trial is a phase II study of daily Tarceva combined with definitive radiotherapy in inoperable locally advanced non small cell lung cancer (stage IIB-IIIB).
- Trial name
- TARLAL (NCT00888511)
- Testing
- Tarceva, Radiotherapy
- Where
- 7 sites in Denmark
- Volunteers
- 15 people
- Sponsor
- Olfred Hansen
Quality of Life, Brain Diseases
Long Term Survivors of High-grade Glioma and Their Caregivers
This study builds on the limited body of existing literature combined with the results from the investigators' previous research conducted with 30 newly diagnosed patients with high-grade glioma (HGG) and 33 of their caregivers.
- Conditions
- Quality of Life, Brain Diseases, Depression, Physical Impairment
- Trial name
- NCT02965144
- Testing
- no treatment
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Elective Surgery
Neuromuscular Blocking Agents in the Elderly
The number of elderly patients (>80 years) is increasing and a large proportion of these patients will require surgery and anaestheasia within the next decades.
- Trial name
- NCT03857750
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hip Dysplasia, Postoperative Complications
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after periacetabular osteotomy.
- Trial name
- DEX-GANZ (NCT03161938)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetes Mellitus, Type II, Hypoglycemia
Effects of Mild Hypoglycaemia on Cognitive Function in Type 2 Diabetes
Hypoglycaemia in subjects suffering from type 2 diabetes may have substantial consequences including a significant negative impact on quality of life.
- Conditions
- Diabetes Mellitus, Type II, Hypoglycemia, Cognitive Change
- Trial name
- NCT03014011
- Testing
- Hypoglycaemic clamp, Euglycaemic clamp
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Bispebjerg Hospital
Aortic Valve Stenosis, Cardiovascular Diseases
Comparison of a Rivaroxaban-based Strategy With an Antiplatelet-based Strategy Following Successful TAVR for the Prevention of Leaflet Thickening and Reduced Leaflet Motion as Evaluated by Four-dimensional, Volume-rendered Computed Tomography (4DCT)
The aortic valve is located between the left ventricle and the aorta. Patients with symptomatic, severe aortic valve stenosis conventionally have it surgically replaced requiring direct access to the heart through the chest.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Ventricular Outflow Obstruction
- Trial name
- GALILEO-4D (NCT02833948)
- Testing
- Acetylsalicylic acid, Clopidogrel, Rivaroxaban
- Where
- 25 sites in United States, Canada and 5 more
- Volunteers
- 231 people
- Sponsor
- ECRI bv
Dexamethasone, Glucocorticoids
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after breast cancer surgery, with removal of the breast (mastectomy).
- Conditions
- Dexamethasone, Glucocorticoids, Mastectomy, Breast Cancer
- Trial name
- DEX-MAS (NCT03125941)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Puberty
The COPENHAGEN Puberty Study
By clinical examinations and withdrawing of blood samples from a large number of healthy Danish children, this study will reveal if age of pubertal onset is declining.
- Trial name
- NCT01411527
- Where
- Denmark
- Volunteers
- 1,957 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Education
Simulation-based Training for Flexible Cystoscopy - a Patient Transfer Randomized Trial
Simulation training in surgical education in Urology specialist training in flexible cystoscopy has been demonstrated a valid and efficient learning instrument.
- Trial name
- NCT02411747
- Testing
- Testing, Directed self-regulated simulation training
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Psychomotor Agitation
Does Intraoperative Clonidine Reduce Post Operative Agitation in Children?
Clonidine is widely used off-label in children for several indications. Clonidine is used for treatment and/or prevention of postoperative agitation in children anaesthetised with Sevoflurane.
- Trial name
- NCT02361476
- Testing
- Clonidine
- Where
- 3 sites in Denmark
- Volunteers
- 379 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gastrointestinal Neoplasms
Cerebral Blood Flow During Propofol Anaesthesia
General anaesthesia often reduces blood pressure whereby blood flow to the brain and other vital organs may become insufficient. Thus, medicine is often administered during anaesthesia to maintain blood pressure.
- Trial name
- NCT02951273
- Testing
- Study of cerebral blood flow
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypoglycemia, Cognitive Impairment
The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
The purpose of this study is to evaluate the cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone system which is involved in the regulation of…
- Trial name
- NCT00264641
- Testing
- Human insulin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hypoglycaemia Research Group
Leukemia, Lymphocytic, Acute
NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic Leukemia
The present pharmacokinetic (PK)-pharmacodynamic (PD) study will explore the toxicity and antileukemic response during the initial 3 months of individualised therapy of children and young adults with acute lymphoblastic leukemia…
- Trial name
- NCT00548431
- Testing
- 6-mercaptopurine
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 38 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet