Clinical trials: sponsored by Imperial College London
Asthma
Non-Eosinophilic Biological Effects of IL-5
This study aims to investigate the role of IL-5 in suppressing anti-viral immune responses in bronchial epithelial cells (BECs) and in peripheral blood mononuclear cells (PBMCs) from 5 people with asthma.
- Trial name
- NCT06026202
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Imperial College London
Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA
Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)
Patients with chronic obstructive pulmonary disease (COPD) experience breathing difficulties because the airways deep in their lungs become narrowed. COPD patients use inhaler drugs to provide relief from breathlessness.
- Conditions
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, HEALTHY SUBJECTS
- Trial name
- NCT01721291
- Testing
- SALBUTAMOL
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Hepatocellular Carcinoma
Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma
The PRIME-HCC trial will assess the effects of combination treatment with nivolumab (OPDIVO) and ipilimumab (YERVOY) pre-operatively in hepatocellular carcinoma patients for whom liver resection is planned.
- Trial name
- PRIME-HCC (NCT03682276)
- Testing
- Ipilimumab, Nivolumab
- Where
- United Kingdom
- Volunteers
- 33 people
- Sponsor
- Imperial College London
Lynch Syndrome
Colonoscopy Check-up in People With Lynch Syndrome
Lynch syndrome, an inherited condition, increases bowel cancer risk. People with Lynch syndrome are recommended to have regular colonoscopies where a camera in a tube is used to look inside the bowel for cancer and for polyps…
- Trial name
- NCT06126120
- Where
- United Kingdom
- Volunteers
- 231 people
- Sponsor
- Imperial College London
Respiratory Tract Infections
Novel Mucosal Correlates Of RSV Protection In Older Adults
Respiratory syncytial virus (RSV) is one of the most common causes of chest infection worldwide. Despite this, it remains an underappreciated health problem, with the first effective RSV vaccines only approved by the FDA in May…
- Trial name
- CHIRP01 (NCT06274619)
- Testing
- RSV A Memphis 37
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Advanced Hepatocellular Carcinoma
Itacitinib in Advanced Hepatocellular Carcinoma
This research will assess the effects of Itacitinib as a second line treatment for patients with advanced inflammatory hepatocellular carcinoma (HCC), a type of liver cancer.
- Trial name
- JAKaL (NCT04358185)
- Testing
- Itacitinib
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Imperial College London
Cancer of Unknown Primary Site
Trial of Pembrolizumab in Cancer of Unknown Primary
Abbreviated Title : CUPem Clinical Indication : A Phase II, Two-Stage, Trial of Pembrolizumab in Cancer of unknown primary Trial Type : Single Arm, non-randomised; Two-stage; Hypothesis generating Type of control : None Route of…
- Trial name
- CUPem (NCT03752333)
- Testing
- Pembrolizumab
- Where
- 3 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Healthy
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.
- Trial name
- ASCENT (NCT04765644)
- Testing
- Celecoxib, L-arginine + celecoxib
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Colorectal Cancer
Axitinib Monotherapy With Early Dynamic Contrast Enhanced Ultrasound Monitoring in Chemorefractory Third Line Metastatic Colorectal Cancer
This is a study of Axitinib versus placebo as monotherapy for people with colorectal cancer who have liver metastases and who have relapsed within 6 months of their last chemotherapy regime.
- Trial name
- AXMUS-C (NCT04355156)
- Testing
- Axitinib
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- Imperial College London
Venous Leg Ulcer
Diagnostics in the Leg Ulcer Pathway
This project aims to investigate 'The minimum diagnostic requirements for patients presenting to primary care with suspected venous ulcers.' In order to do this, the investigators intend to run a series of questionnaires with…
- Trial name
- NCT06181708
- Testing
- N/A - Questionnaire based study
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cardiovascular Diseases, Acute Coronary Syndrome
Telemedicine in High-Risk Cardiovascular Patients Post-ACS
This is a non-CTIMP randomised controlled trial looking at the utilisation of telemedicine devices to provide remote, clinically necessary, diagnostic information, without the need for hospital attendance that patients will take…
- Trial name
- TELE-ACS (NCT05015634)
- Testing
- Active Arm, Control Arm
- Where
- United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
Atrial Fibrillation
Specific Electrophenotypes in Atrial Fibrillation
This study will investigate a common heart rhythm disturbance (arrhythmia), atrial fibrillation (AF), to improve understanding of how best to treat it in different patients.
- Trial name
- INSPECT-AF (NCT05366530)
- Testing
- Biomarkers, electrocardiographic imaging, intracardiac electrograms, cardiac magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Imperial College London
Acute Coronary Syndrome, Myocardial Infarction
OptimiZation Of Lipid Lowering Therapies Using a Decision Support System In Patients With Acute Coronary Syndrome.
The goal of this clinical trial is to compare implementation of a Decision Support System (DSS) - aligned to the 2019 ESC/EAS Guidelines - in addition to routine clinical care versus routine clinical care without availability of…
- Trial name
- ZODIAC (NCT05844566)
- Testing
- Decision Support System (DSS)
- Where
- 42 sites in Italy, Spain and 1 more
- Volunteers
- 1,139 people
- Sponsor
- Imperial College London
RSV Infection
The Impact of Age on Adaptive Immunity in Adults Infected With Respiratory Syncytial Virus
This study will for the first time systematically investigate the immune responses in an elderly cohort challenged with a well-defined RSV inoculum.
- Trial name
- INFLAMMAGE (NCT03728413)
- Testing
- RSV A Memphis 37
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Helminthiasis, Filariasis
Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)
Over 1.5 billion people are infected with soil-transmitted helminths (STH). Global STH guidelines recommend MDA (mass drug administration) of albendazole or mebendazole to targeted populations, including pre-school age children…
- Trial name
- NCT03014167
- Testing
- Albendazole
- Where
- 3 sites in Benin, India and 1 more
- Volunteers
- 357,716 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Positive, Ageing
The Effects of Ageing on the 'Pharmacokinetic and Clinical Observations in People Over Fifty'
The purpose of this study is to identify medical conditions that may cause particular problems to individuals receiving care for HIV infection over the age of 50.
- Trial name
- POPPY (NCT01737047)
- Where
- 8 sites in Ireland, United Kingdom
- Volunteers
- 1,377 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetic Foot, Peripheral Arterial Disease
Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes
In the UK there are over 7,000 leg amputations each year because of diabetes. The most important cause of this is poor circulation. The detection of poor circulation in patients with diabetes is difficult.
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Diabetic Foot Ulcer, Peripheral Vascular Diseases
- Trial name
- DM PAD (NCT05009602)
- Testing
- Toe Brachial Pressure Index (TBPI), Ankle Brachial Pressure Index (ABPI), Exercise Ankle Brachial Pressure Index (ABPI)
- Where
- 17 sites in United Kingdom
- Volunteers
- 604 people
- Sponsor
- Imperial College London
May-Thurner Syndrome
The Use and Reproducibility of Duplex Ultrasound to Provide Indices of Left Common Iliac Vein Diameter
The goal of this feasibility/pilot study is to investigate whether or not vascular ultrasound can be used to aid the diagnosis of May Thurner Syndrome, in adult patients presenting to the vascular department with unexplained left…
- Trial name
- NCT06180122
- Testing
- Duplex ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
COPD, LUNG DISEASES, OBSTRUCTIVE
Airway Effects of Tiotropium in Patients With COPD
The aim of the study is to investigate the effect of tiotropium from different devices on a panel of small (IOS, MBNW, DLCO, FVC) and large airway (FEV1, PEF) responses in patients with mild-moderate COPD.
- Trial name
- NCT02683668
- Testing
- Handihaler-Tiotropium 18 mcg untrained, Handihaler-Tiotropium 18 mcg trained, Respimat-Tiotropium 5 mcg trained
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Imperial College London