Clinical trials: sponsored by UMC Utrecht
Acute Otitis Media, Pain
Analgesic Ear Drops for Children With Acute Otitis Media
This trial aims to investigate whether analgesic ear drops added to usual care provide superior ear pain relief over usual care alone in children presenting to primary care with AOM.
- Trial name
- OPTIMA (NCT05651633)
- Testing
- lidocaine hydrochloride 5mg/g
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- UMC Utrecht
Locked-In Syndrome
First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
In this study a new means of communication for people with locked-in syndrome will be tested. The investigators will record brain signals directly from the surface of the brain by means of a completely implantable system.
- Trial name
- UNP (NCT02224469)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- UMC Utrecht
COVID-19
Characterising Transmission of SARS-CoV-2 in a Peri-urban Population in Mozambique
A population-based COVID19 surveillance in a household cohort will be set-up using an existing Household demographic surveillance system (HDSS).
- Trial name
- AfriCoVER (NCT04442165)
- Where
- Mozambique
- Volunteers
- 6,049 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Respiratory Tract Infections
ADEQUATE Advanced Diagnostics for Enhanced Quality of Antibiotic Prescription
To assess the impact of rapid diagnostic testing of patients with Acute Respiratory Tract Infection (ARTI) at the emergency department, on (1) hospital admission rates and (2) antimicrobial prescriptions (days of treatment) and…
- Trial name
- ADEQUATE (NCT04547556)
- Testing
- BioFire
- Where
- 4 sites in Belgium, Hungary and 1 more
- Volunteers
- 185 people
- Sponsor
- UMC Utrecht
Perinatal Arterial Ischemic Stroke, Neonatal Stroke
Perinatal Arterial Stroke Treated With Stromal Cells Intranasally
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, administered by the nasal route, in neonates who suffered from PAIS.
- Trial name
- PASSIoN (NCT03356821)
- Testing
- Mesenchymal Stem Cells
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Clostridium Difficile Infection
COMBACTE-CDI Understanding the Burden of C. Difficile Infection
Clostridium difficile infection (CDI) is the most common cause of antibiotic associated diarrhoea in the western world. The infection causes significant diarrhoea, which in some cases can be serious and lead to secondary…
- Trial name
- COMBACTE-CDI (NCT03503474)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 3,240 people
- Sponsor
- University of Leeds
HSV-2 Infection, Genital Herpes
The VIBLOK SAfety and perFormancE Trial
Genital herpes has a high prevalence in industrialized as well as developing countries. Genital herpes causes genital ulcers, increases risk for acquiring HIV infection, and may be transmitted mother to child during birth with…
- Trial name
- SAFE (NCT03080961)
- Testing
- VIBLOK barrier cream
- Where
- 3 sites in Netherlands
- Volunteers
- 82 people
- Sponsor
- CLJI Worldwide
Hypotension
Decision Support for Intraoperative Low Blood Pressure
The purpose of this study is to determine whether a decision support system can improve the adherence to thresholds for low blood pressure by anesthesia providers, which in turn prevents their patients from having organ injury.
- Trial name
- NCT02726620
- Testing
- Attending real-time decision support, In-room real-time decision support, Attending feedback emails
- Where
- United States
- Volunteers
- 22,435 people
- Sponsor
- Vanderbilt University Medical Center
Peripheral Arterial Disease
Edoxaban in Peripheral Arterial Disease
This study is a randomized, open-label, blinded endpoint, parallel-group, active-control, multi-center, proof-of-concept study in subjects with Peripheral Arterial Disease (PAD), designed to assess the safety and potential…
- Trial name
- ePAD (NCT01802775)
- Testing
- edoxaban, Clopidogrel, Aspirin
- Where
- 42 sites in United States, Austria and 5 more
- Volunteers
- 203 people
- Sponsor
- Daiichi Sankyo
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Chest Pain
Impact on Management of the HEART Risk Score in Chest Pain Patients
Aim of this study is to quantify the impact of the use of the HEART risk score on patient outcome and on costs in patients with chest pain presenting at the emergency room, as compared to not using the score.
- Trial name
- HEART-Impact (NCT01756846)
- Testing
- usual care, use of HEART risk score
- Where
- 9 sites in Netherlands
- Volunteers
- 3,666 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Foreign-Body Reaction, Inflammation
IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee.
Articular cartilage defects in the knee have a poor intrinsic healing capacity and may lead to functional disability and osteoarthritis.
- Conditions
- Foreign-Body Reaction, Inflammation, Effusion (L) Knee, Knee Pain Swelling
- Trial name
- IMPACT (NCT02037204)
- Testing
- Cartilage repair surgery
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- UMC Utrecht
Anxiety, Depression
Coping Intervention After Embryo Transfer
Background of the study: Undergoing an IVF or ICSI treatment is an emotional and physical burden for both the woman and her partner.
- Trial name
- NCT01701011
- Testing
- Coping intervention
- Where
- Netherlands
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Hepatitis C, Human Immunodeficiency Virus
Dutch Acute HCV in HIV Study (DAHHS)
Prospective open label proof of concept feasibility interventional clinical trial in which 60 acute HCV genotype 1 patients co-infected with HIV will receive 12 weeks of boceprevir in addition to Standard Of Care Peginterferon +…
- Trial name
- DAHHS (NCT01912495)
- Testing
- Boceprevir
- Where
- 9 sites in Netherlands
- Volunteers
- 65 people
- Sponsor
- Erasmus Medical Center
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Cetrotide Treatment Optimization
Rationale: In daily practice fertility treatment is increasingly patient focused and innovative medication and standardized treatment guidelines are being developed to improve patient convenience.
- Trial name
- NCT00866034
- Testing
- Cetrotide (Ovarian stimulation)
- Where
- Netherlands
- Volunteers
- 617 people, healthy volunteers welcome
- Sponsor
- Bart CJM Fauser
Metabolic Syndrome
The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study
The purpose of this study is to investigate whether low-dose simvastatin in combination with ezetimibe in comparison to high-dose simvastatin alone, has a beneficial effect on the function of the endothelium after an oral fat…
- Trial name
- PANACEA (NCT00817843)
- Testing
- Simvastatin, Simvastatin/Ezetimibe
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 100 people
- Sponsor
- dr.Frank L.J. Visseren
Chronic Otitis Media
Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media
Chronic suppurative otitis media is one of the most common chronic infections in children worldwide. Symptoms include otorrhea, otalgia and hearing loss.
- Trial name
- NCT00189098
- Testing
- Sulfamethoxazole-trimethoprim
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- UMC Utrecht