Clinical trials: sponsored by University of Rochester
Asthma in Children
Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)
Physical activity (PA) is an important component of asthma management in children. Studies show that PA is associated with decreased severity of asthma symptoms, as well as improved disease control and quality of life.
- Trial name
- NCT04576442
- Testing
- Asthma-PASS, Basic Asthma Management (AM), Child/Caregiver Education session
- Where
- United States
- Volunteers
- 452 people
- Sponsor
- Montefiore Medical Center
End Stage Renal Disease, Chronic Kidney Diseases
Shared Decision Making in Dialysis
Older patients ≥65 years with chronic kidney disease (CKD) face challenges in decision making about dialysis. These patients report little effort by physicians to elicit treatment preferences, discuss prognoses, or explain the…
- Trial name
- DIAL-SDM (NCT04392440)
- Testing
- DIAL-SDM, usual care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Rochester
Human Metapneumovirus, Human Parainfluenza Virus Type 3
Study of the Infectivity, Safety and Immunogenicity of Two Recombinant, Live-Attenuated, B/HPIV3 Vectored Vaccines Expressing the Fusion Glycoprotein of HMPV Delivered by Nasal Spray to HPIV3-Seropositive Children 24 to <60 Months of Age
HPIV3 and HMPV are viruses that can cause breathing problems in children. The goal of this clinical trial is to look at the safety of 2 experimental HPIV3/HMPV vaccines in HPIV3-seropositive children ≥ 24 months to < 60 months of…
- Trial name
- NCT06546423
- Testing
- B/HPIV3/HMPV-PreF-A vaccine, B/HPIV3/HMPV-F-B365 vaccine
- Where
- 4 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Vaping, Preventive Psychiatry
Network Intervention to Prevent Vaping
Rates of adolescent vaping are increasing rapidly. Current high school student use of electronic vaping products (EVPs) rose from 1.5% in 2011 to 20.8% in 2018 - an increase from 220,000 to 3.05 million adolescent users.
- Conditions
- Vaping, Preventive Psychiatry, Social Networking
- Trial name
- NCT04678245
- Testing
- Above the Influence-Vaping (ATI-V)
- Where
- United States
- Volunteers
- 3,950 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Loneliness
Modifiers and Mechanisms of Loneliness Interventions
A specific aim of this research is to identify the role of emotion regulation in response to social threat in caregivers' response to a behavioral coaching intervention for loneliness.
- Trial name
- NCT05812989
- Testing
- Social Engage Coaching, Connect for Caregivers
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Rochester
Bone Metabolism Biomarkers, Bone Mineral Density
Vitamin D and Physical Activity on Bone Health
This research will examine the effectiveness of vitamin D or placebo (the placebo is a tablet that looks like Vitamin D study drug, but has no Vitamin D study drug in it), with and without physical activity (walking and…
- Conditions
- Bone Metabolism Biomarkers, Bone Mineral Density, Physical Fitness
- Trial name
- NCT01419730
- Testing
- Vitamin D3, Physical Activity
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- University of Rochester
Cigarette Smoking
Free Samples for Health
The Free Samples for Health (FreSH) study tests whether providing free samples of stop smoking medicine called nicotine replacement therapy at dental visits results in a greater number of people quitting smoking than providing a…
- Trial name
- FreSH (NCT05627596)
- Testing
- Ask-Advise-Refer, Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release, Nicotine lozenge
- Where
- United States
- Volunteers
- 1,239 people
- Sponsor
- Sandra Japuntich
Smoldering Multiple Myeloma
Denosumab for Smoldering Multiple Myeloma
This study will assess the safety and tolerability of denosumab in smoldering multiple myeloma subjects as well to see if denosumab can reduce subjects' risk of getting multiple myeloma.
- Trial name
- NCT03839459
- Testing
- Denosumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Rochester
Electronic Cigarette Use
Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems
This is a randomized, parallel-group open-label trial to evaluate respiratory symptoms in ENDS users switching from banned flavors to a non-banned flavor (tobacco) or 'tobacco free' nicotine pouches.
- Trial name
- CRoFT (NCT05423340)
- Testing
- E-cigarette Flavor, Tobacco Free Nicotine Pouch
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Advanced Rectal Cancer
Neoadjuvant FOLFOX Therapy With Short Course Radiation and Active Surveillance in Locally Advanced Rectal Cancer
The purpose of this study is to evaluate the treatment of patients with locally advanced rectal cancer for complete response to neoadjuvant chemotherapy without the use of radiation and surgery.
- Trial name
- NCT03781323
- Testing
- FOLFOX
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Cancer Patients, Young Adult
Bright IDEAS - Young Adults Problem-Solving Skills Training
The purpose of this project is to evaluate efficacy of Bright IDEAS, an evidence-based problem-solving skills training (PSST) program, as a supportive care intervention for young adult (YA) cancer patients compared with enhanced…
- Conditions
- Cancer Patients, Young Adult, Supportive Care
- Trial name
- NCT04585269
- Testing
- Bright IDEAS-YA
- Where
- 3 sites in United States
- Volunteers
- 344 people
- Sponsor
- Rutgers, The State University of New Jersey
Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4
Safety, Feasibility and Efficacy of Sulforaphane (Avmacol Extra Strength) in Chronic Kidney Disease
The Sulforaphane Production System® in Avmacol Extra Strength (ES) supplies broccoli seed extract (glucoraphanin) and Myrosimax® (Active Myrosinase Enzyme) which helps promote sulforaphane production in your body.
- Trial name
- NCT05797506
- Testing
- Sulforaphane (Avmacol Extra Strength)
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Rochester
Pregnant and Parenting Women
Promotion of Successful Parenting
Home visitation by community health workers is a commonly utilized approach to support families and prevent child maltreatment. At times, however, more intensive intervention is needed to address familial trauma, depression, or…
- Trial name
- PROMISE (NCT03808987)
- Testing
- Child-Parent Psychotherapy (CPP), Community Health Worker (CHW) home visitation
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Prostate Cancer, Multiple Myeloma
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer
To explore the use of curcumin and piperine supplementation at a dose of 4 gram/5mg twice a day in early stage prostate cancer patient undergoing active surveillance or patients on observation for MGUS/ low-risk smoldering…
- Conditions
- Prostate Cancer, Multiple Myeloma, Smoldering Multiple Myeloma (SMM), Monoclonal Gammopathy of Undetermined Significance
- Trial name
- NCT04731844
- Testing
- Curcumin plus Piperine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Acute Myeloid Leukemia
A Patient-Centered Communication Tool (UR-GOAL) Versus Usual Care for Older Patients With Acute Myeloid Leukemia, Their Caregivers, and Their Oncologists
The objective of this study is to evaluate the preliminary efficacy of the UR-GOAL tool in improving shared decision making and communication between older patients with AML and their oncologists in a pilot randomized trial.
- Trial name
- UR-GOAL 2 (NCT05335369)
- Testing
- UR-GOAL
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Rochester
Frailty, Inflammation
Reducing Frailty for Older Cancer Survivors Using Supplements
The purpose of the study is to examine the feasibility and safety of twelve weeks oral supplementation of Epigallocatechin-3-gallate (EGCG) in older survivors of cancer
- Trial name
- ReFOCUS1 (NCT04553666)
- Testing
- Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Rochester
Advanced Renal Cell Carcinoma
Software Monitoring of Treatment Related Toxicities in Advanced Renal Cell Carcinoma
To determine if Carevive software, which monitors treatment-related toxicities and then generates self-care management plans for these symptoms, will be feasible to implement among patients with metastatic renal cell carcinoma…
- Trial name
- NCT03229083
- Testing
- Carevive software
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Rochester
Caregivers of People With Dementia
A Cultural Adaptation of the Caregiver TLC Psychoeducational Program to Support Latino Caregivers (CUIDANDO JUNTOS)
This study will test the feasibility and influence of a behavioral intervention called "Cuidando Juntos" in Latino caregivers of people with dementia.
- Trial name
- CuidandoJuntos (NCT06394388)
- Testing
- Cuidando juntos
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Rochester
Acute Myeloid Leukemia
A Patient-centered Communication Tool (UR-GOAL) for Older Patients With Acute Myeloid Leukemia, Their Caregivers, and Their Oncologists
This is a pilot study to evaluate the usability and feasibility of a patient-centered communication tool (University of Rochester-Geriatric Oncology Assessment for acute myeloid Leukemia or UR-GOAL) among 15 older patients with…
- Trial name
- UR-GOAL 1 (NCT04625413)
- Testing
- Behavioral: UR-GOAL communication tool
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester