Condition
Heart Failure Clinical Trials
Studies of heart failure, matched by condition name and medical subject headings. Start with those open to enrolment.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 1,476Heart Failure
Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
Background: More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year.
- Trial name
- NCT06280820
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Heart Failure
Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload
This trial aims to identify the best strategy for treating acute heart failure (AHF) with volume overload in patients at risk of diuretic resistance.
- Trial name
- DRAIN-AHF (NCT06166654)
- Testing
- Acetazolamide, Metolazone 2.5 MG
- Where
- 6 sites in Denmark
- Volunteers
- 939 people
- Sponsor
- Johannes Grand
Atrial Fibrillation (Paroxysmal), Hypertension
Renal Denervation in Patients With Atrial Fibrillation and Hypertension
High blood pressure is a major risk factor for atrial fibrillation (AF), an irregular heart rhythm, and heart failure with preserved ejection fraction (HFpEF), a condition in which the heart becomes stiff and cannot relax…
- Conditions
- Atrial Fibrillation (Paroxysmal), Hypertension, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07893821
- Testing
- Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Pavel Antiperovitch
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Heart Failure, Muscle Atrophy
Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure
This study aims to determine, via skeletal muscle ultrasound (US), the extent, timing and relationship between skeletal muscle mass loss and outcomes after orthotropic heart transplantation (OHT) and left ventricular assist…
- Conditions
- Heart Failure, Muscle Atrophy, Skeletal Muscle Atrophy, Cardiogenic Shock
- Trial name
- NCT06253104
- Testing
- BodyMetrix Body Composition Ultrasound
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tufts Medical Center
Atrial Functional, Mitral Regurgitation (MR)
PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk
Atrial functional mitral regurgitation (AFMR) develops when enlargement and remodeling of the left atrium and mitral annulus prevent the mitral valve leaflets from closing completely, allowing blood to leak backward through the…
- Trial name
- PRECISE-AFMR I (NCT07741253)
- Testing
- Transcatheter Edge-to-Edge Repair
- Where
- China
- Volunteers
- 182 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Hypertension
A Clinical Study of Sotatercept (MK-7962) in People With Combined Postcapillary and Precapillary Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (MK-7962-041)
Researchers are looking for other ways to treat people with combined postcapillary and precapillary pulmonary hypertension (CpcPH).
- Trial name
- CHORUS (NCT07839585)
- Testing
- Sotatercept
- Volunteers
- 352 people
- Sponsor
- Merck Sharp & Dohme LLC
Heart Failure, Heart Failure With Preserved Ejection Fraction
Assessment of CCM in HF With Higher Ejection Fraction
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.
- Conditions
- Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction
- Trial name
- AIM HIGHer (NCT05064709)
- Testing
- Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, OPTIMIZER™ Smart Mini System
- Where
- 67 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Impulse Dynamics
Heart Failure
Mobile Health Intervention to Increase Activity in Heart Failure Study
Physical activity is known to help patients with heart failure feel better and live longer though few patients with heart failure are sufficiently active.
- Trial name
- MOVIN-HF (NCT07750262)
- Testing
- Mobile application intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Heart Failure With Reduced Ejection Fraction
Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
RECOVER HF is a clinical study designed to evaluate the safety and efficacy of Synchronized Diaphragmatic Stimulation delivered using the VisONE System in the treatment of patients with heart failure.
- Trial name
- RECOVER-HF (NCT06552637)
- Testing
- Synchronized Diaphragmatic Stimulation
- Where
- 5 sites in United States, Georgia
- Volunteers
- 270 people
- Sponsor
- VisCardia Inc.
Completed, with results posted
All 787Chronic Disease, Frail
Functional Exercise and Nutrition Education Program for Older Adults
There is strong evidence that specific types of exercise can improve health and physical function in older adults. While community exercise classes exist, many older adults with chronic conditions may need guidance from…
- Conditions
- Chronic Disease, Frail, Diabetes Mellitus, Cancer
- Trial name
- MoveStrong (NCT04037436)
- Testing
- Strength and Balance Training & Nutrition Education, Usual Care
- Where
- 5 sites in Canada
- Volunteers
- 44 people
- Sponsor
- University of Waterloo
Chronic Heart Failure
Acupuncture on Cardiac and Autonomic Function in Human Heart Failure
Acupuncture treatment may improve the cardiac function and the quality of life in heart failure patients. These effects may be related to the inhibition of sympathetic activity and/or increased vagal function.
- Trial name
- NCT01804816
- Testing
- Acupuncture, No Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The Cleveland Clinic
HIV/AIDS, Heart Failure With Preserved Ejection Fraction
The ENCHANTMENT HIV Study
Persons with HIV, even those well-treated, are at increased risk for heart disease when compared to the general population. Two hormones called aldosterone and brain natriuretic peptide (BNP), which have been shown to be abnormal…
- Trial name
- NCT04153136
- Testing
- Sacubitril-Valsartan 49-51Mg Oral Tablet
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Heart Failure
Patient-centered Mobile Health Intervention to Improve Self-care in Patients With Chronic Heart Failure
Approximately 6.5 million people have heart failure (HF) in the United States, and 960,000 new cases are reported each year. HF is one of the most common hospital diagnosis among older adults.
- Trial name
- iCardia4HF (NCT03642275)
- Testing
- iCardia4HF
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois at Chicago
Heart Failure
REGN5381 in Heart Failure Adult Participants With Elevated Pulmonary Capillary Wedge Pressure
This study is researching an experimental drug called REGN5381, further referred to as study drug. The study is focused on adult participants with heart failure that, in the opinion of the study doctor, have a clinical indication…
- Trial name
- NCT05353166
- Testing
- REGN5381
- Where
- Moldova
- Volunteers
- 59 people
- Sponsor
- Regeneron Pharmaceuticals