Drug or intervention
conventional surgery Clinical Trials
Studies that test conventional surgery, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 1,021Bladder Cancer
Role of ERBT Plus Intravesical BCG in Intermediate-Risk or High-Risk NMBC
This is a prospective, multi-centre randomised trial comparing between cTURBT plus 1-year BCG therapy, and ERBT plus 1-year BCG therapy, in patients with intermediate-risk or high-risk NMIBC.
- Trial name
- NCT07724886
- Testing
- Conventional Transurethral Resection of Bladder Tumour, Transurethral En Bloc Resection of Bladder Tumour
- Where
- 2 sites in Hong Kong
- Volunteers
- 732 people
- Sponsor
- Chinese University of Hong Kong
Hemostasis, Surgical Blood Loss
Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray Amputation
This is a multicentre, prospective, three-arm, parallel-group randomized controlled superiority trial evaluating fibrillar Type-I collagen haemostat (Hemocoll®) FTC, Avitene™ Microfibrillar Collagen Hemostat (MCH), and…
- Conditions
- Hemostasis, Surgical Blood Loss, Amputation Stump, Hemorrhage
- Trial name
- CANHAEM-Ray (NCT07788846)
- Testing
- Hemocoll® Fibrillar type-I collagen haemostat, Bone wax, Avitene™ Microfibrillar Collagen Hemostat
- Where
- 3 sites in India
- Volunteers
- 135 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Cataract, Endothelial Cell Density
Trial Comparing miLOOP Device Assisted Phacoemulsification vs Standard Surgery for Dense Cataracts: Effects on Endothelial Cell Loss, Energy Use, and Vision Recovery
The goal of this clinical trial is to find out if using the miLOOP device during cataract surgery confers additional protection against cornea (endothelial) cells loss by reducing the amount of ultrasound energy needed.
- Conditions
- Cataract, Endothelial Cell Density, Cumulative Dispersive Energy
- Trial name
- NCT07898007
- Testing
- The miLOOP utilizes a nickel-titanium (nitinol) loop to ensnare and exert centripetal cutting forces on the lens nucleus with decreasing loop diameter, Conventional phacoemulsification cataract surgery
- Where
- Malaysia
- Volunteers
- 68 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Kidney Calculi, Nephrolithiasis
Comparison of Suction and Conventional Ureteral Access Sheaths in Kidney Stone Surgery
The goal of this observational study is to compare conventional and suction (aspiration) ureteral access sheaths used during retrograde intrarenal surgery (RIRS) in adults with kidney stones.
- Trial name
- NCT07866209
- Testing
- Conventional Ureteral Access Sheath, Suction Ureteral Access Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Antalya Health Sciences University
Periodontitis, Periodontitis Stage II
Spirulina Gel in the Treatment of Periodontitis
This randomized clinical trial aims to evaluate the clinical and immunological effects of locally delivered Spirulina gel as an adjunct to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- non (NCT07893587)
- Testing
- spirulina gel exracted by 1.5% calcium chloride (CaCl2) aqueous solution., conventional scaling and root planing
- Volunteers
- 20 people
- Sponsor
- Misr University for Science and Technology
Endometrial Cancer, Cervical Cancer (Early Detection)
Remote Robotic Surgery for Gynecologic Cancer: A Safety and Effectiveness Study
This investigator-initiated, multicenter, single-blind, randomized controlled clinical study is designed to evaluate the safety and effectiveness of the MP2000 thoracoabdominal endoscopic surgical system (Shenzhen Jingfeng…
- Trial name
- RRS-GYN-RCT (NCT07896720)
- Testing
- MP2000 Thoracoabdominal Endoscopic Surgical System
- Volunteers
- 92 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Coronary Revascularization, Coronary Artery Disease
The CORE Platform Trial
Background: The leading cause of death worldwide is cardiovascular disease, with an estimated 19.8 million deaths per year. Coronary artery disease is a type of cardiovascular disease that can be treated with revascularisation…
- Trial name
- CORE (NCT07892976)
- Testing
- MIDCAB procedure, CABG procedure
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 15,000 people
- Sponsor
- Copenhagen Trial Unit, Center for Clinical Intervention Research
Malignant Testicular Germ Cell Tumor
MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial
This study evaluates the accuracy of blood-based biomarker testing to predict the presence of active testicular cancer.
- Trial name
- NCT06060873
- Testing
- Clinical Stage I Disease, Clinical Stage I with relapse, CSII Disease
- Where
- 7 sites in United States, Canada
- Volunteers
- 418 people
- Sponsor
- University of Southern California
Nephrolithiasis, Kidney Calculi
Ureteral Access Strategies in Retrograde Intrarenal Surgery
Retrograde intrarenal surgery (RIRS) is a standard minimally invasive treatment for kidney stones up to 20 mm. During the procedure, irrigation fluid raises the pressure inside the kidney and laser energy raises the fluid…
- Conditions
- Nephrolithiasis, Kidney Calculi, Retrograde Intrarenal Surgery, Flexible Ureteroscopy
- Trial name
- NCT07898020
- Testing
- Flexible and navigable suction ureteral access sheath, Conventional ureteral access sheath, Sheathless flexible ureteroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Ondokuz Mayıs University
Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma
Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer
This phase Ib trial tests the safety, side effects, and best dose of M1774 when given with ZEN-3694 in treating patients with ovarian and endometrial cancer that has come back (recurrent).
- Conditions
- Recurrent Endometrial Carcinoma, Recurrent Endometrial Clear Cell Adenocarcinoma, Recurrent Endometrial Endometrioid Adenocarcinoma, Recurrent Endometrial Low Grade Endometrioid Adenocarcinoma
- Trial name
- NCT05950464
- Testing
- BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection
- Where
- 14 sites in United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Completed, with results posted
All 290Endometriosis
Cardiovascular Disease Risk in Women With Endometriosis
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
- Trial name
- NCT03746535
- Testing
- Elagolix
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Stage I Prostate Adenocarcinoma, Stage II Prostate Adenocarcinoma
Stereotactic Body Radiation Therapy With Boost Using Urethral-Sparing Intensity-Modulated Radiation Therapy Planning in Treating Patients With Prostate Cancer
This phase I/II trial studies the side effects and best dose of stereotactic body radiation therapy while using intensity-modulated radiation therapy (IMRT) planning to help avoid radiation to normal tissue in patients with…
- Trial name
- NCT02470897
- Testing
- Radiation Therapy Treatment Planning and Simulation, SBRT
- Where
- 3 sites in United States
- Volunteers
- 115 people
- Sponsor
- University of Wisconsin, Madison
HER2-Positive Breast Carcinoma, Hormone Receptor-Positive Breast Carcinoma
Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients With Hormone Receptor-Positive, HER2-Positive Operable or Locally Advanced Breast Cancer
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen…
- Conditions
- HER2-Positive Breast Carcinoma, Hormone Receptor-Positive Breast Carcinoma, Stage IB Breast Cancer AJCC v7, Stage IIA Breast Cancer AJCC v6 and v7
- Trial name
- NCT02003209
- Testing
- Aromatase Inhibition Therapy, Carboplatin, Cytology Specimen Collection Procedure
- Where
- 732 sites in United States, Puerto Rico
- Volunteers
- 315 people
- Sponsor
- National Cancer Institute (NCI)
Minimal Flow Anesthesia, General Anaesthesia
Minimal Flow Anesthesia and Infection Risk
This study is being done to find out if the heat and moisture that build up during minimal flow anesthesia can lead to the growth of germs (microorganisms) inside the anesthesia equipment.
- Conditions
- Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia, Infection Risk
- Trial name
- NCT07092046
- Testing
- Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Anemia
Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients
The objective of this study is to evaluate the efficacy and safety of RBC transfusion for support of acute anemia in cardiovascular surgery patients based on the clinical outcome of renal impairment following transfusion of red…
- Trial name
- ReCePI (NCT03459287)
- Testing
- INTERCEPT, Control
- Where
- 18 sites in United States
- Volunteers
- 581 people
- Sponsor
- Cerus Corporation