Clinical trials: conventional surgery
Weaning Failure
Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit
monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included random assignation in two…
- Trial name
- NCT03505814
- Testing
- High Flow Nasal Cannula Oxygen therapy (OPTIFLOW®), Conventional oxygen therapy
- Where
- Tunisia
- Volunteers
- 126 people
- Sponsor
- Hôpital d'enfants Béchir-Hamza
Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present
Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma
This phase I/II trial studies the side effects and best dose of genetically modified T cells in treating patients with stage III-IV non-small cell lung cancer (NSCLC) or mesothelioma.
- Conditions
- Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present, Recurrent Non-Small Cell Lung Carcinoma, Recurrent Pleural Malignant Mesothelioma
- Trial name
- NCT02408016
- Testing
- Aldesleukin, Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes, Cyclophosphamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Fred Hutchinson Cancer Center
Gummy Smile
Fully Digital Guided Esthetic Crown Lengthening Surgery
The goal of this randomized controlled clinical study is to compare Fully digital to wax-up/mock-up guided esthetic crown lengthening procedure in management of excessive gingival display caused by altered passive eruption type…
- Trial name
- NCT06801548
- Testing
- Esthetic crown lengthening surgery, Esthetic crown lengthening surgery using Digital guide
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University
Echocardiography, Aortic Valve
Short- and Medium-term Results of New Generation Aortic
Over the past decade, aortic valve replacement surgery has undergone significant changes in terms of both the approaches and the prostheses used.
- Conditions
- Echocardiography, Aortic Valve, Cardiac Surgery, Mortality
- Trial name
- RVANG (NCT05055089)
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Venous Insufficiency
National Varicose Vein Study - Portugal
The National Varicose Vein Study is a cross-sectional, multicenter, observational study. The primary goal is to evaluate the 30 days outcome of the conventional great saphenous vein surgery (stripping) in the treatment of the…
- Trial name
- NCT05625074
- Testing
- Conventional surgery for great saphenous vein insufficiency
- Where
- Portugal
- Volunteers
- 250 people
- Sponsor
- Universidade do Porto
Brain and Central Nervous System Tumors
Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas
RATIONALE: Diagnostic procedures, such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI), (done before, during, and after treatment) may help doctors predict a patient's response to treatment…
- Trial name
- NCT00274755
- Testing
- chemotherapy, conventional surgery, magnetic resonance imaging
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Francisco
Gastrectomy, Laparoscopy
A Clinical Study for Comparison of the Effects Between Gasless Laparoscopy and Conventional Laparoscopy for Distal Gastric Cancer
The aim of this trial is to confirm the non-inferiority of Gasless laparoscopy-assisted distal D2 radical gastrectomy to the conventional laparoscopy-assisted distal D2 radical gastrectomy for the treatment of advanced gastric…
- Trial name
- NCT05495217
- Testing
- Conventional Laparoscopy, Gasless Laparoscopy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xue Yingwei
Postoperative Atelectasis, Postoperative Pulmonary Complications
HFNC for Postoperative Atelectasis After Laparoscopic Surgery
Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative…
- Trial name
- NCT07676760
- Testing
- High-Flow Nasal Cannula (HFNC), Conventional Oxygen Therapy
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Delirium, Postoperative
Effect of Percutaneous Acupoint Electrical Stimulation on Delirium
This study is a multicenter, prospective, randomized controlled clinical trial that aims to observe the impact of Transcutaneous Electrical Acupoint Stimulation (TEAS) on plasma TK/MMP3 in a randomized controlled setting.
- Trial name
- NCT06360549
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Qin Zhang
Paediatric Outpatient Surgery
Reduction of Preoperative Anxiety in Children: Electronic Tab vs Midazolam
Rationale: The most frequently used means to prevent pre-anaesthetic anxiety in children is a drug premedication. Midazolam, a benzodiazepine, is mainly used.
- Trial name
- IPAD (NCT02192710)
- Testing
- electronic tab, Midazolam oral intake
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Hospices Civils de Lyon
B-Cell Non-Hodgkin Lymphoma
Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy
This phase II trial studies how well anakinra works in decreasing the occurrence of cytokine release syndrome (CRS) and damage to the nerves (neurotoxicity) in patients with B-cell non-Hodgkin lymphoma who are receiving CD-19…
- Trial name
- NCT04359784
- Testing
- Anakinra, X-Ray Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Fred Hutchinson Cancer Center
Abdomen Hernia, Respiratory Complication
Virtual Reality on Pulmonary Function After Upper Abdominal Surgeries
After upper abdomen surgery, respiratory muscle dysfunction is well recognised. After laparotomy and even laparoscopy, maximum static inspiratory and expiratory pressures are lowered, and recovery can take several days.
- Trial name
- NCT06301126
- Testing
- Virtual reality, conventional physical therapy exercise program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Endometriosis, Quality of Life
The Impact of NOSE-colectomy on Fertility and Quality of Life Among Patients With Colorectal Endometriosis
Deep infiltrating endometriosis (DIE) represents the most severe form of endometriosis and is present in 20-35% of all women suffering from the disease. Intestinal nodules are observed in 3% to 37% of endometriosis patients.
- Trial name
- NOSERES (NCT04109378)
- Testing
- Surgical procedures( conventional laparoscopic and NOSE technique) for the treatment of colorectal DIE
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Semmelweis University
Abdominal Aortic Aneurysm
Endoprosthesis Treatment Effects on Human Abdominal Aorta Aneurysms (AAA) Metabolic Activity
The purpose of this study is to determine whether Positron Emission Tomography imaging can help to predict the evolutivity of AAA treated with endovascular prosthesis.
- Trial name
- AAAendo (NCT01253252)
- Testing
- [18F] Fluorodeoxyglucose PET Scan Imaging, CT scan, Blood sampling for biological investigations
- Where
- 7 sites in France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Breast Cancer
Targeted T Cells After Neoadjuvant Chemotherapy in Treating Women With Stage II or III Breast Cancer Undergoing Surgery
RATIONALE: Neoadjuvant chemotherapy for women with stage II-III Her negative breast cancer followed by Her2Bi armed activated T cells (ATCs) may significantly improve the pathologic complete response (pCR) rate at the time of…
- Trial name
- NCT01147016
- Testing
- HER2Bi-armed activated T cells, cyclophosphamide, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Borderline Resectable Pancreatic Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma
Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer
This pilot and feasibility study studies how well nivolumab and combination chemotherapy work before surgery in treating patients with pancreatic cancer that could possibly be removed by surgery.
- Trial name
- NCT03970252
- Testing
- Fluorouracil, Irinotecan, Irinotecan Hydrochloride
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Coronary Artery Disease
Effect of Rotablator on Balloon Resistant Calcified Coronary Lesion
The optimal treatment of calcified coronary lesion remained to be elucidated. A Prospective, randomized controlled trial was perform to explore the immediate effect and long-term outcome of rotational atherectomy in patients with…
- Trial name
- NCT01887704
- Testing
- Rotablator, conventional angioplasty, stenting
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Brain and Central Nervous System Tumors
Magnetic Resonance Imaging in Treating Children With Progressive Low-Grade Astrocytoma
RATIONALE: New imaging procedures such as magnetic resonance imaging may improve the ability to determine the growth rate of progressive astrocytoma.
- Trial name
- NCT00005084
- Testing
- conventional surgery, magnetic resonance spectroscopic imaging, radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Missing Teeth, Edentulous Alveolar Ridge
Hybrid Funnel Technique a Innovative Technique for Implant Site Preparation
Hybrid Funnel Technique arises from the union of subtractive and non-subtractive techniques for implant site preparation. Hybrid funnel technique is performed with specially designed drills and osteotome.
- Conditions
- Missing Teeth, Edentulous Alveolar Ridge, Tooth Loss
- Trial name
- NCT05499533
- Testing
- implant site preparation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Luigi Canullo
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