Drug or intervention
Treatment as Usual (TAU) Clinical Trials
Studies that test Treatment as Usual (TAU), alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 339Opioid Use Disorder
Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD
The researchers will study the KIOS app, a digital health tool made to help people recovering from opioid addiction take better care of themselves.
- Trial name
- NCT07348796
- Testing
- KIOS App
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Substance Use Disorder (SUD)
Fighting Addictions, Improving Lives: COmprehensive Drug Rehabilitation With Music
FALCO is a parallel pragmatic randomized control trial addressing long-term effects of music therapy (MT) on substance use disorder (SUD). 600 participants will be recruited from multiple European countries (see Locations).
- Trial name
- FALCO (NCT07028983)
- Testing
- Active Music Group (AMG), Music Listening Group (MLG), Treatment as Usual (TAU)
- Where
- 11 sites in Austria, Israel and 6 more
- Volunteers
- 600 people
- Sponsor
- NORCE Norwegian Research Centre AS
Alcohol Use and Intimate Partner Violence
Adjunctive Motivational Alcohol Intervention to Prevent IPV
This is a study to provide much-needed experimental data on the efficacy of a brief alcohol Motivational Enhancement Therapy (MET) pre-group intervention for Veterans receiving group treatment for IPV perpetration.
- Trial name
- MET-SAH (NCT05287711)
- Testing
- Motivational Enhancement Therapy, Alcohol Education Control, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Agitation in Dementia, Including Alzheimer's Disease
Virtual Darkness Theraphy for Agitation in Dementia
Behavioral and psychological symptoms of dementia (BPSD) such as anxiety, depression, psychosis and agitation, are prevalent, often treatment resistant, resource demanding and significantly deteriorates cognition, independency…
- Trial name
- DARKDEM (NCT06451952)
- Testing
- Virtual darkness
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University of Bergen
Psychiatric Disorder, Involuntary Psychiatric Hospitalization
A Brief Case Management Intervention to Promote Personal Recovery and Prevent Psychiatric Involuntary Readmissions.
The goal of this randomized control trial is to assess the effectiveness of a Brief Case Management (BCM) intervention aimed at promoting personal recovery and reducing the negative effects of coercion among people involuntarily…
- Trial name
- CARP-RCT (NCT07497763)
- Testing
- Brief Case Management intervention, TAU
- Where
- Switzerland
- Volunteers
- 262 people
- Sponsor
- Stéphane Morandi
Depressive Disorder, Major Depressive Disorder, Suicidal Ideation
Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults With Depression
The goal of this clinical trial is to learn if a multi-layered digital and pharmacogenomic intervention works to prevent suicide re-attempts in adults with depression.
- Conditions
- Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- SMARTomicS (NCT07885722)
- Testing
- Digital Monitoring (Active/Passive EMA), Ecological Momentary Intervention (EMI) via Digital Safety Plan, Pharmacogenetic-Guided Care and Therapeutic Drug Monitoring
- Where
- Spain
- Volunteers
- 525 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Autism Spectrum Disorder
FMS-CrossFit Training Program (FCTP) to Improve School Readiness in Preschool Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is an increasing public health concern, with preschool children often exhibiting persistent deficits in school readiness.
- Trial name
- NCT07532395
- Testing
- FCTP program, treatment as usual (TAU) (Control Group)
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Peking University
Major Depressive Disorder (MDD)
Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU
Problem statement. Major Depressive Disorder (MDD) is a significant concern among adolescents, characterized by episodes of mood changes, cognitive symptoms, and neurovegetative dysfunction, often lasting months or even years…
- Trial name
- CARIBOU-FR (NCT07806825)
- Testing
- CARIBOU Integrated Care Pathway, Treatment as Usual (TAU)
- Where
- Chile
- Volunteers
- 72 people
- Sponsor
- Universidad de los Andes, Chile
Idiopathic Pulmonary Fibrosis
Autoantibody Reduction Therapy for Progressive Idiopathic Pulmonary Fibrosis
This Phase IIb trial will compare effectiveness and safety of a multi-component autoantibody reduction therapy (AART), consisting of therapeutic plasma exchange (TPE), rituximab, and intravenous immunoglobulin (IVIg) for…
- Trial name
- STRIVE II (NCT07674745)
- Testing
- Therapeutic Plasma Exchange, Rituximab, Intravenous immunoglobulin
- Where
- 9 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Alabama at Birmingham
Opioid Use Disorder (OUD)
MethaLoad Dose-Finding Study
Methadone is an effective treatment for opioid use disorder (OUD), but starting it has become harder now that most people with OUD use fentanyl. Methadone is usually started at a low dose and increased slowly over several weeks.
- Trial name
- NCT06877858
- Testing
- Methadone hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ashish P Thakrar, MD MS
Completed, with results posted
All 135Chronic Pain
ElderTree Smart System for Older Adults
Multiple chronic conditions (MCCs) are costly and pervasive among older adults. MCCs account for 90% of Medicare spending, and 65% of Medicare beneficiaries have 3 or more chronic conditions; 23% have 5 or more.
- Trial name
- NCT04798196
- Testing
- ElderTree on laptop (ET- LT), ElderTree on smart system (ET- SS), Treatment as usual (TAU)
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Opioid Use Disorder, Medication Adherence
MHealth Incentivized Adherence Plus Patient Navigation
Polysubstance use involving opioids and methamphetamine is emerging as a new public health crisis. Patients with opioids and methamphetamine use often experience serious medical complications requiring hospitalization, which…
- Conditions
- Opioid Use Disorder, Medication Adherence, Polysubstance Drug Use (Indiscriminate Drug Use), Methamphetamine-dependence
- Trial name
- MIAPP (NCT06027814)
- Testing
- Patient Navigation and mHealth (PN+mHealth)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Parenting, Adolescent - Emotional Problem
Optimizing Residential Treatment Gains for Adolescents
The goal of this randomized controlled trial is to determine the feasibility, acceptability, and preliminary effects of a web-based parent training augmented with facilitated parent groups.
- Conditions
- Parenting, Adolescent - Emotional Problem, Mental Disorder in Adolescence
- Trial name
- NCT05764369
- Testing
- Parenting Wisely Residential Treatment (PWRT), TAU
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Ohio State University
Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute
Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration
The investigators are conducting a randomized controlled trial to assess the impact of Resiliency in Stressful Experiences (RISE) - a comprehensive trauma-based program for young men releasing from a southeastern state's prisons.
- Conditions
- Stress Disorders, Traumatic, Stress Disorders, Traumatic, Acute, Depressive Symptoms, Anxiety
- Trial name
- NCT04785677
- Testing
- Resiliency in Stressful Experiences (RISE) Program
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- Florida State University