Research institution
Hadassah Medical Organization Clinical Trials
Studies where Hadassah Medical Organization is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 33Relapsed/Refractory Multiple Myeloma (RRMM), Light-Chain Amyloidosis
Phase 1a/b Study of GPRC5D CART Therapy in Relapsed/Refractory Multiple Myeloma and Light-chain Amyloidosis
A Phase 1a/b Open-Label Study to Evaluate Safety and Preliminary Efficacy of GPRC5D CART Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma and Light-chain Amyloidosis.
- Trial name
- NCT07874334
- Testing
- GPRC5D CART
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Hadassah Medical Organization
Relapsed/Refractory Multiple Myeloma (MM)
Study of Naive HBI0101 CAR-T Therapy in Relapsed/Refractory Multiple Myeloma
A Phase 1a/1b Open-Label Study with Dose Escalation and Expansion Phases to Evaluate Safety and Preliminary Efficacy of Naïve HBI0101 CART Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma.
- Trial name
- NCT07333430
- Testing
- Naive HBI0101 CAR-T
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Labor Pain
Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural Analgesia
The current "gold standard" epidural analgesia for labor is associated with unwanted side effects, such as motor block (affecting ambulation and the ability to push) and sympathetic blockade (causing maternal hypotension).
- Trial name
- PSALM (NCT06302257)
- Testing
- Chlorprocaine, Lidocaine, Lidocaine-chlorprocaine combination
- Where
- 3 sites in Israel
- Volunteers
- 303 people
- Sponsor
- Hadassah Medical Organization
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Preeclampsia (PE), Hypertension ,Pregnancy
Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological Effects
Early-onset preeclampsia (PE), defined as preeclampsia presenting before 34 weeks of gestation, is a severe placental disorder associated with significant maternal and perinatal morbidity.
- Trial name
- NCT07738562
- Testing
- Dipyridamole 75 MG
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Hadassah Medical Organization
Bronchiolitis Obliterable Syndrome
Forced Oscillatory Technique for Bronchiolitis Obliterans Syndrome After Allogeneic Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS) is a severe pulmonary complication following allogeneic hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT07730931
- Testing
- FOT - Forced Oscillation Technique
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hadassah Medical Organization
Pain After Surgery, PSP
Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT/TVT-O Surgery. Randomized Double-Blind Trial
This randomized, double-blind controlled trial will evaluate whether intraoperative injection of bupivacaine at the sling insertion site reduces postoperative pelvic and thigh pain in women undergoing TVT or TVT-O surgery for…
- Conditions
- Pain After Surgery, PSP, Chronic Pain Syndrome, Local Anesthesia Infiltration
- Trial name
- PAIN-TVT (NCT07429019)
- Testing
- Bupivacain (Postoperative)
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Labor, Obstetric, Pregnancy
Obstetric Risk Assessment & Cesarean-delivery in Labor Estimation Using Artificial Intelligence
ORACLE-AI is a single-center, open-label, randomized clinical trial comparing primiparous women managed with a real-time machine-learning dashboard against a concurrent control group receiving standard intrapartum care.
- Conditions
- Labor, Obstetric, Pregnancy, Cesarean Section Rate
- Trial name
- ORACLE-AI (NCT07430358)
- Testing
- Software-based, real-time AI dashboard providing continuous risk estimates for unplanned cesarean delivery during labor.
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cancer Related Cognitive Impairment, Breast Cancer Survivor
The Computerized Retraining and Functional Treatment - Group Intervention
The goal of this clinical trial is to examine the efficacy of a novel, remotely-applied group intervention, Cognitive Retraining and Functional Treatment Group (CRAFT-G), designed to improve cognitive function, mental health and…
- Trial name
- CRAFT-G (NCT07591857)
- Testing
- CRAFT-G, CCT
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Hadassah Medical Organization
Healthy
Determinants of Warfarin Metabolism
The anticoagulant effect of warfarin varies greatly among individuals. Some of this variability is attributed to differences in the activity of CYP2C9, the predominant enzyme involved in the metabolism of S-warfarin.
- Trial name
- NCT00162474
- Testing
- Warfarin, Phenytoin, Losartan & Hydrochlorothiazide
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Completed, with results posted
All 10Conscious Sedation
Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care
The general objective of the study is to compare the efficacy of administering midazolam orally as syrup versus nasally with nasal atomizer.
- Trial name
- NCT02679781
- Testing
- oral midazolam, nasal midazolam
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Dental Anxiety
Waiting Room's Environment and Children Anxiety Prior Dental Treatment
The amount of time the patient has spent awaiting treatment and the nature of the waiting room environment influence the anxiety level prior treatment.
- Trial name
- NCT03197129
- Testing
- sensory adapted waiting room
- Where
- Israel
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bowel Dysfunction
Gastrointestinal Activation Post-elective CS (Cesarean Section) :A Comparison of Paula Method to Standard Care
Women generally report discomfort and a delay in GI motility after CS. The Paula method, circular exercises of ring muscles has been shown to increase GI motility. This method had not been studied in women post CS.
- Trial name
- NCT03761147
- Testing
- Paula exercises
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Pain, Postoperative, Analgesia
Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
The aim of the study is to compare the efficacy of the pre-operative administration of Paracetamol and placebo in reducing postoperative pain after routine dental treatment in children.
- Trial name
- NCT02393339
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Children's Dental Anxiety
Reducing Children's Anxiety Using Homeopathic Remedy Before Dental Treatment
Pharmacological interventions to aid behavior management's techniques are commonly used in pediatric dentistry. The aim of the medicaments is to control behavior and allow safe completion of a dental procedure.
- Trial name
- NCT01658059
- Testing
- Homeopathic remedy
- Where
- Israel
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization