Clinical trials: sponsored by Hadassah Medical Organization
Dyspareunia (Female)
Rigid Hymenal Ring as a Cause for Insertional Dyspareunia
Given the frequently observed rigid hymenal ring as a cause of insertional dyspareunia as well as the resolution of pain (including posterior vestibulodynia) following its targeted therapy, the study aims to describe its…
- Trial name
- NCT07913386
- Testing
- Hymenectomy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Bone Marrow Transplant Complications
Vaginal Microbiome and the Development of Vulvovaginal Graft Versus Host Disease
The suggested study aims to evaluate a possible association between vaginal microorganisms (the "microbiome") to the progress of VV-GVHD.
- Trial name
- NCT05316740
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Urinary Tract Infections, Menopause
Characterization of Vaginal, Urinary and Fecal Microbiomes in Women With Recurrent Urinary Tract Infections
The objectives are to evaluate whether variations in vaginal and/or urinary and/or fecal microbiome predispose postmenopausal women to recurrent cystitis.
- Trial name
- NCT04305808
- Where
- Israel
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Human Papilloma Virus, Vaginal Flora Imbalance
Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia
In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to…
- Conditions
- Human Papilloma Virus, Vaginal Flora Imbalance, Cancer Cervix Uterus, Cervical Dysplasia
- Trial name
- NCT05640700
- Where
- Israel
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Periodontitis, Adult
Garlic Product Impact on Periodontitis (GPIP)
This is a randomized, controlled, examiner-blind, 2-treatment parallel group study. The study will be conducted at the Hebrew University, Hadassah, Israel.
- Trial name
- NCT03492723
- Testing
- Aged Garlic Extract
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Panic Disorder
Exosomal microRNAs as a Biomarker in Panic Disorder and in Response to CBT
Cognitive behavior therapy (CBT) has long been known as an effective treatment for anxiety disorders, either when given by a therapist or when self-administered through a computer program.
- Trial name
- NCT04029740
- Testing
- CBT- both internet and face to face, No intervention
- Where
- Israel
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hebrew University of Jerusalem
Relapsed/Refractory Multiple Myeloma (RRMM), Light-Chain Amyloidosis
Phase 1a/b Study of GPRC5D CART Therapy in Relapsed/Refractory Multiple Myeloma and Light-chain Amyloidosis
A Phase 1a/b Open-Label Study to Evaluate Safety and Preliminary Efficacy of GPRC5D CART Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma and Light-chain Amyloidosis.
- Trial name
- NCT07874334
- Testing
- GPRC5D CART
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Hadassah Medical Organization
Relapsed/Refractory Multiple Myeloma (MM)
Study of Naive HBI0101 CAR-T Therapy in Relapsed/Refractory Multiple Myeloma
A Phase 1a/1b Open-Label Study with Dose Escalation and Expansion Phases to Evaluate Safety and Preliminary Efficacy of Naïve HBI0101 CART Therapy for the Treatment of Relapsed/Refractory Multiple Myeloma.
- Trial name
- NCT07333430
- Testing
- Naive HBI0101 CAR-T
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Dietary Fibers, Intermediate Fasting
The Role of the Microbiome in the Response to Dietary Fibers Intake During Intermittent Fasting
Dietary fibers are generally not degraded by the endogenous digestive enzymes, but rather by the complex ensemble of microorganisms that reside in the human gut [1].
- Trial name
- NCT04633369
- Testing
- dietary fibers, Intermediate fasting
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Postdural Puncture Headache, Cerebrospinal Fluid Leak
Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics
The SNOB study is a prospective, randomized, double-blind, placebo-controlled, cross-over pragmatic trial that has been designed in accordance with the CONSORT guidelines.
- Conditions
- Postdural Puncture Headache, Cerebrospinal Fluid Leak, Spinal; Puncture, Complications, Headache
- Trial name
- SNoB (NCT03181464)
- Testing
- Lidocaine 4%
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Recurrent Bacterial Vaginitis
Vaginal Flora for Treatment of Bacterial Vaginosis
Bacterial vaginosis (BV) is the most common vaginal infection in women. It is caused by a vaginal bacterial imbalance. Treatment with antibiotics is the standard of care but there is a high rate of recurrence.
- Trial name
- VFT (NCT02236429)
- Testing
- vaginal flora transplant
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Constipation, Constipation - Functional
The Effects of TTNS, TTNS Combined With PHUS, and Conventional Therapy With PHUS in the Treatment of PFC.
This study is a randomized, controlled trial designed to evaluate the effects of transcutaneous tibial nerve stimulation (TTNS), TTNS combined with pocket-sized handheld ultrasound (PHUS), and conventional therapy with PHUS on…
- Trial name
- constipation (NCT07077044)
- Testing
- The transcutaneous posterior tibial nerve stimulation device, PSUS
- Where
- Israel
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Schizoaffecitve Disorder, Schizophrenia and Schizoaffective Disorder
Combination Therapy of Deferiprone and N-Acetylcysteine for Treating Negative Symptoms in Schizophrenia
In following guidelines for studying negative symptoms in schizophrenia, 60 patients aged 18-40, diagnosed with schizophrenia or schizoaffective disorder during the last ten years, will receive a combination of the iron chelator…
- Conditions
- Schizoaffecitve Disorder, Schizophrenia and Schizoaffective Disorder, Schizophrenia and Predominant Negative Symptoms
- Trial name
- IronMan (NCT07759895)
- Testing
- Deferiprone (DFP), N-Acetyl Cysteine (NAC)
- Where
- 2 sites in Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Amit Lotan
Bacterial Vaginoses
Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis
Vaginal Microbiome Transplantation (VMT) may be beneficial in treating the most severe cases of recurrent and antibiotics-nonresponsive cases of BV.
- Trial name
- NCT04517487
- Testing
- Vaginal Microbiome Transplantation (VMT)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Labor Pain
Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural Analgesia
The current "gold standard" epidural analgesia for labor is associated with unwanted side effects, such as motor block (affecting ambulation and the ability to push) and sympathetic blockade (causing maternal hypotension).
- Trial name
- PSALM (NCT06302257)
- Testing
- Chlorprocaine, Lidocaine, Lidocaine-chlorprocaine combination
- Where
- 3 sites in Israel
- Volunteers
- 303 people
- Sponsor
- Hadassah Medical Organization
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Obesity, Weight Loss
The Role of Microbiome in Recurrent Obesity Before and After Antibiotic/Placebo Treatment
This past century witnessed a significant increase in the prevalence of obesity. Successful weight loss maintenance is defined as losing at least 10% of the initial body weight and maintaining it for at least one year.
- Trial name
- NCT06681246
- Testing
- Antibiotic treatment
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Preeclampsia (PE), Hypertension ,Pregnancy
Dipyridamole for Early-Onset Preeclampsia: A Pilot Study of Feasibility, Pharmacokinetics, and Biological Effects
Early-onset preeclampsia (PE), defined as preeclampsia presenting before 34 weeks of gestation, is a severe placental disorder associated with significant maternal and perinatal morbidity.
- Trial name
- NCT07738562
- Testing
- Dipyridamole 75 MG
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Hadassah Medical Organization
Bronchiolitis Obliterable Syndrome
Forced Oscillatory Technique for Bronchiolitis Obliterans Syndrome After Allogeneic Bone Marrow Transplantation
Bronchiolitis obliterans syndrome (BOS) is a severe pulmonary complication following allogeneic hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT07730931
- Testing
- FOT - Forced Oscillation Technique
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hadassah Medical Organization
Type 2 Diabetes Mellitus in Obese
Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide
This study aims to test whether a multi-disciplinary intervention involving exercise and nutrition can slow down the decline in physical function, muscle strength and mass in older adults (aged 65 and above) with Type 2 diabetes…
- Trial name
- STAY-STRONG (NCT06497595)
- Testing
- Wegovy (2.4 Mg Dose) + exercise & nutrition, Wegovy (2.4 Mg Dose) + usual care
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center