Research institution
Maastricht University Medical Center Clinical Trials
Studies where Maastricht University Medical Center is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 81Small Cell Lung Cancer, Brain Metastases, Adult
Tarlatamab for SCLC Brain Metastases
A single arm phase II study evaluating intracranial efficacy of tarlatamab in patients with asymptomatic active brain metastases from small cell lung cancer (SCLC).
- Trial name
- T-BRAIN (NCT07402343)
- Testing
- Tarlatamab
- Where
- 4 sites in Netherlands
- Volunteers
- 35 people
- Sponsor
- Maastricht University Medical Center
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT)
Real-world Evaluation of the Implementation of LC-OCT in Daily Clinical Practice
Basal cell carcinoma (BCC) is the most common skin cancer in the Netherlands, with incidence rates continuing to rise. The current diagnostic standard combines clinical evaluation and dermoscopy, while biopsy followed by…
- Conditions
- Basal Cell Carcinoma of Skin, Optical Coherence Tomography (OCT), Neoplasms, Neoplasms, Basal Cell
- Trial name
- RELI (NCT07501780)
- Where
- Netherlands
- Volunteers
- 297 people
- Sponsor
- Maastricht University Medical Center
Prehabilitation, Pancreas Cancer
Preoperative Optimisation of Modifiable Risk Factors in Surgery of the Pancreas
The goal of this stepped-wedge randomized controlled trial is to investigate whether implementation of a best practice program for preoperative optimisation (prehabilitation program) with a focus on screening, assessment, and…
- Conditions
- Prehabilitation, Pancreas Cancer, Surgery, Postoperative Complications
- Trial name
- PROMISE-P (NCT05851534)
- Testing
- Preoperative optimisation program
- Where
- 13 sites in Netherlands
- Volunteers
- 2,575 people
- Sponsor
- Maastricht University Medical Center
Heart Failure, Cardiomyopathies
The Multicenter Cardiology Monitoring Platform Registry
The multicenter Cardiology Monitoring Platform registry (mCMP-registry) is a prospective observational registry including multi-omics (diagnostic) measurements performed as part of routine clinical care, bio-banking (optional)…
- Conditions
- Heart Failure, Cardiomyopathies, Atrial Fibrillation, Ventricular Arrythmia
- Trial name
- mCMPregistry (NCT04976348)
- Where
- Netherlands
- Volunteers
- 40,000 people
- Sponsor
- Maastricht University Medical Center
Lifestyle Intervention, Lifestyle Risk Reduction
Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial
Lifestyle Intervention in the memory clinics of General and academic Hospitals Trial (LIGHT) is a multi-center, randomized, controlled, lifestyle intervention trial among 300 older adults (≥50 years) with subjective cognitive…
- Conditions
- Lifestyle Intervention, Lifestyle Risk Reduction, Cognitive Decline, Dementia
- Trial name
- LIGHT (NCT06832761)
- Testing
- Personalized lifestyle intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Maastricht University Medical Center
Hemorrhagic Disorders, Bleeding Disorder of Unknown Cause
Bleeding Disorder of Unknown Cause in the Netherlands
The purpose of the Bleeding Disorder of Unknown Cause in the Netherlands study (BDUC-iN) is to learn more about unexplained bleeding in individuals with a bleeding disorder of unknown cause (BDUC).
- Trial name
- BDUC-iN (NCT07454161)
- Where
- 8 sites in Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
Prospective Evaluation of Flare Detection in IBD With Digital Biomarkers: Bring Your Own Device Study
The aim of this study is to identify HRV changes predictive of IBD flares using patient-own wearable devices in a large cohort supplemented by additional data layers including sleep parameters, step count and clinical data…
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- BYOD (NCT07647640)
- Testing
- Wearing their own wearable device.
- Where
- 3 sites in Netherlands
- Volunteers
- 600 people
- Sponsor
- Maastricht University Medical Center
Depression, Unipolar
FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction.
- Trial name
- NCT05640089
- Testing
- fMRI-based neurofeedback
- Where
- 3 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury, Severe Traumatic Brain Injury
Optimal Cerebral Perfusion Pressure Guided Therapy: Assessment of Target Effectiveness - II
After severe traumatic brain injury, adequate blood flow to the brain is essential for recovery. This depends on arterial blood pressure, yet intensive care units apply fixed targets to all patients - treating every brain and…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Intracranial Pressure, Cerebral Perfusion Pressure
- Trial name
- Cogitate II (NCT07287358)
- Testing
- Optimal cerebral perfusion pressure
- Where
- 4 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Maastricht University Medical Center
Completed, with results posted
All 9Fruit and Vegetable Consumption in Children
Kokkerelli Learning Street Effect Evaluation
In 2012, the Kids University for Cooking Foundation BV has developed a nutrition education programme called 'Kokkerelli Learning Street'.
- Trial name
- NCT04190680
- Testing
- Kokkerelli Learning Street
- Where
- Netherlands
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Health and Wellbeing of Primary School-aged Children
Healthy Childcare Centre of the Future
Rationale: In 2015-2020, the Dutch 'Healthy Primary School of the Future' intervention took place. Two schools became 'Healthy Primary Schools of the Future'; providing a healthy lunch and structured physical activity (PA)…
- Trial name
- HCCF (NCT04193410)
- Testing
- Various health-promoting initiatives
- Where
- Netherlands
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Irritable Bowel Syndrome, Abdominal Pain
Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®), a Pharmacokinetic Study
This is a pilot study to compare the relative bioavailability between two peppermint oil formulations, namely a ileocolonic release peppermint oil and an small intestinal release peppermint oil (Tempocol®).
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases, Visceral Pain
- Trial name
- NCT02291445
- Testing
- Menthae piperitae aetheroleum/peppermint oil (enteric coated capsule), Menthae piperitae aetheroleum/peppermint oil (colon-targeted-delivery capsule)
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hepatitis B
Safety and Immunogenicity of HBAI20 Hepatitis B Vaccine in Naive Adults and Non-responders
The purpose of this study is to determine whether the HBAI20 vaccine is safe and more immunogenic than the HBVaxPro-10µg in people who have never been vaccinated with a hepatitis B vaccine and in people who have been vaccinated 6…
- Trial name
- NCT02540538
- Testing
- HBVaxPro, HBAI20
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Ovarian Cancer, Sentinel Node
Sentinel Node Detection in Clinical Early Stage Ovarian Cancer
As most cancers, ovarian cancer also spreads to regional lymph nodes. The concept of sentinel lymph node surgery is to see whether the cancer has spread to the very first lymph node or sentinel node (SN).
- Trial name
- SONAR (NCT01734746)
- Testing
- Tracerinjection
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Maastricht University Medical Center