Research institution
Nantes University Hospital Clinical Trials
Studies where Nantes University Hospital is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 178Chirurgical Intervention, Thrombocytopaenia
Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery.
Romiplostim has demonstrated its efficacy and good tolerance in multiple indications. If the efficacy of Romiplostim is confirmed in this population, thrombocytopenic patients will be able to undergo cardiac surgery, which is…
- Trial name
- CT-PLATE (NCT07278661)
- Testing
- Nplate, NaCl %0.9
- Where
- 8 sites in France
- Volunteers
- 142 people
- Sponsor
- Nantes University Hospital
Hereditary Heart Diseases
Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease
Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. These deaths (more than 5,000 per year in France) are due to hereditary arrhythmias or cardiomyopathies.
- Trial name
- PREVENT (NCT07257289)
- Testing
- Blood sample
- Where
- 15 sites in France, Martinique and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Infective Endocarditis
Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis
The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months…
- Trial name
- RIFREE (NCT07345325)
- Testing
- Rifampin-free regimen, Rifampin containing regimen
- Where
- 31 sites in France
- Volunteers
- 422 people
- Sponsor
- Nantes University Hospital
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Solid Tumor (Excluding CNS)
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance.
- Trial name
- Pulmojet 3 (NCT07408375)
- Testing
- High-Frequency Jet Ventilation (HFJV)
- Where
- 7 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Hypersensitivity Pneumonitis
Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a diffuse infiltrative pneumonitis (DIP) of immuno-allergic origin, caused by exposure to one or more antigenic substances of organic origin, in genetically predisposed individuals.
- Trial name
- PHSaDom (NCT05988437)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Gambling Disorder
Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study
The PASSENGER project aims to conduct a pilot feasibility study of the implementation of a randomized clinical trial on psilocybin-assisted psychotherapy for the treatment of gambling disorder.
- Trial name
- PASSENGER (NCT07391332)
- Testing
- Psychotherapy assisted by high-dose psilocybin (25mg or 40mg where appropriate), Psychotherapy assisted by low-dose psilocybin (1 mg)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Burnout
Study of Psychosocial and Contextual Determinants of General Practitioners' Management of Burnout
Burnout is a major public and occupational health issue. Despite accumulated knowledge to date on the determinants of burnout and its treatment, shortcomings when providing support against this complex phenomenon have been found.
- Trial name
- BOPEC-MG (NCT06811181)
- Where
- France
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Severe Bacterial Infections
Identification of Clinical, Genetic and Immunological Factors Involved in the Development of Severe Bacterial Infections in Pediatrics
Severe bacterial infections (SBI) are responsible for significant morbidity and mortality in the paediatric population. There is considerable individual variability in children's susceptibility to developing SBIs.
- Trial name
- IBSoFACTo (NCT07111793)
- Testing
- Extended phenotyping, Blood sample for WES, Blood sample for PBMC freezing
- Where
- 7 sites in France
- Volunteers
- 1,401 people
- Sponsor
- Nantes University Hospital
Pancreatic Transplant
"IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ"
A prospective, open-label, uncontrolled, non-randomized, single-center Phase I/II clinical trial evaluating the safety of Anakinra in the immediate post-transplant period following pancreatic transplantation
- Trial name
- ILIPO (NCT07503834)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Nantes University Hospital
Completed, with results posted
All 1Venous Ulcer
Comparison of the Effectiveness of Two Medical Compression Bandage Application Techniques by Measuring Interface Pressures Depending on Whether or Not the Heel is Included in Patients With Open Venous Ulcers
The importance of wearing medical compression to heal the venous ulcer has already been shown. However, no studies have been carried out on variations in medical compression tape and their impact on interface pressures which…
- Trial name
- COMPARACHILLE (NCT04046120)
- Testing
- Heel-free bandage
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Nantes University Hospital