Clinical trials: sponsored by Nantes University Hospital
Heterozygous Familial Hypercholesterolemia
Assessment of the Prevalence of Steatotic Liver Disease Associated With Metabolic Dysfunction in Patients With Heterozygous Familial Hypercholesterolemia
The main goal of the STEATO-FH study is to determine the prevalence of liver steatosis within the Heterozygous Familial Hypercholesterolemia patient population.
- Trial name
- STEATO-FH (NCT06634160)
- Testing
- Fibroscan, Sample collection
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Chirurgical Intervention, Thrombocytopaenia
Preoperative Use of Romiplostim in Thrombocytopenic Patients Undergoing Cardiac Surgery.
Romiplostim has demonstrated its efficacy and good tolerance in multiple indications. If the efficacy of Romiplostim is confirmed in this population, thrombocytopenic patients will be able to undergo cardiac surgery, which is…
- Trial name
- CT-PLATE (NCT07278661)
- Testing
- Nplate, NaCl %0.9
- Where
- 8 sites in France
- Volunteers
- 142 people
- Sponsor
- Nantes University Hospital
Hereditary Heart Diseases
Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease
Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. These deaths (more than 5,000 per year in France) are due to hereditary arrhythmias or cardiomyopathies.
- Trial name
- PREVENT (NCT07257289)
- Testing
- Blood sample
- Where
- 15 sites in France, Martinique and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Fall
Impact of Telephone Coaching on Physical Performance in a Physical Exercise Maintenance Program for Fallers Elderly Patients Living at Home
At home, maintenance, physical performance declines more or less rapidly from 6 weeks depending advancing age and duration of the training period .
- Trial name
- STEP-PA (NCT02828826)
- Testing
- telephone coaching
- Where
- 10 sites in France
- Volunteers
- 101 people
- Sponsor
- Nantes University Hospital
Bacteremia
Predicting the Optimal Empirical Antibiotic Therapy for Bacteremia Using an Artificial Intelligence-based Model
Bacteremia, a common infection associated with high morbidity and mortality, requires prompt and appropriate antibiotic treatment.
- Trial name
- OPTIBact (NCT07894237)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 8,765 people
- Sponsor
- Nantes University Hospital
Infective Endocarditis
Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis
The primary objective of this study is to demonstrate that a rifampin-free regimen is non-inferior to the rifampin-containing regimen in terms of all-cause mortality in staphylococcal prosthetic valve endocarditis within 6 months…
- Trial name
- RIFREE (NCT07345325)
- Testing
- Rifampin-free regimen, Rifampin containing regimen
- Where
- 31 sites in France
- Volunteers
- 422 people
- Sponsor
- Nantes University Hospital
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Ischemia Lesions
Polytetrafluoroethylen (PTFE) Vascular Prostheses With Heparin Bonded Luminal Surfaces vs Crude ePTFE
Open repair could be recommended in a first line of treatment to revascularize critical limb ischemia patients or performed in a second line of treatment in case of failure of endovascular repair.
- Trial name
- REPLACE (NCT03430076)
- Testing
- revascularization, Propaten®, Crude PTFE
- Where
- 21 sites in France
- Volunteers
- 228 people
- Sponsor
- Nantes University Hospital
Solid Tumor (Excluding CNS)
Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology
Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance.
- Trial name
- Pulmojet 3 (NCT07408375)
- Testing
- High-Frequency Jet Ventilation (HFJV)
- Where
- 7 sites in France
- Volunteers
- 560 people
- Sponsor
- Nantes University Hospital
Hypersensitivity Pneumonitis
Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis
Hypersensitivity pneumonitis (HP) is a diffuse infiltrative pneumonitis (DIP) of immuno-allergic origin, caused by exposure to one or more antigenic substances of organic origin, in genetically predisposed individuals.
- Trial name
- PHSaDom (NCT05988437)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Gambling Disorder
Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study
The PASSENGER project aims to conduct a pilot feasibility study of the implementation of a randomized clinical trial on psilocybin-assisted psychotherapy for the treatment of gambling disorder.
- Trial name
- PASSENGER (NCT07391332)
- Testing
- Psychotherapy assisted by high-dose psilocybin (25mg or 40mg where appropriate), Psychotherapy assisted by low-dose psilocybin (1 mg)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Aortic Root Aneurysm, Aortic Regurgitation
Aortic Valve-sparing Root Replacement, According to the Inclusion Technique Described by Tirone David
Retrospective observational study of all patients undergoing aortic root surgery with aortic valve conservation, using the inclusion technique described by Tirone David, between January 1, 2004 and December 31, 2020, at six…
- Trial name
- AORTLANTIC (NCT05515848)
- Testing
- No intervention
- Where
- 5 sites in France
- Volunteers
- 529 people
- Sponsor
- Nantes University Hospital
Burnout
Study of Psychosocial and Contextual Determinants of General Practitioners' Management of Burnout
Burnout is a major public and occupational health issue. Despite accumulated knowledge to date on the determinants of burnout and its treatment, shortcomings when providing support against this complex phenomenon have been found.
- Trial name
- BOPEC-MG (NCT06811181)
- Where
- France
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Severe Bacterial Infections
Identification of Clinical, Genetic and Immunological Factors Involved in the Development of Severe Bacterial Infections in Pediatrics
Severe bacterial infections (SBI) are responsible for significant morbidity and mortality in the paediatric population. There is considerable individual variability in children's susceptibility to developing SBIs.
- Trial name
- IBSoFACTo (NCT07111793)
- Testing
- Extended phenotyping, Blood sample for WES, Blood sample for PBMC freezing
- Where
- 7 sites in France
- Volunteers
- 1,401 people
- Sponsor
- Nantes University Hospital
Pancreatic Transplant
"IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ"
A prospective, open-label, uncontrolled, non-randomized, single-center Phase I/II clinical trial evaluating the safety of Anakinra in the immediate post-transplant period following pancreatic transplantation
- Trial name
- ILIPO (NCT07503834)
- Testing
- Anakinra 100Mg/0.67Ml Inj Syringe
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Nantes University Hospital
Chronic Pain
"Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study."
Chronic pain is a major public health issue. According to the most recent sources, it affects around 11 million people in France, leading to a significant deterioration in patients' quality of life, limitations in their…
- Trial name
- LIDOC-POPEYE (NCT07869173)
- Testing
- Lidocain
- Where
- 6 sites in France
- Volunteers
- 266 people
- Sponsor
- Nantes University Hospital
Coccyx Disorder, Neuropathic Pain
Study Evaluating the Analgesic Efficacy of Capsaicin 8% Patches in Chronic Coccygodynia.
The primary objective is to demonstrate the analgesic effect at day 60 of 8% capsaicin patch (Qutenza) for the treatment of patients with coccygodyinia.
- Conditions
- Coccyx Disorder, Neuropathic Pain, Coccygodynia
- Trial name
- CAPSACOX (NCT06023706)
- Testing
- Capsaicin 179 Mg Cutaneous Patch, Capsaicin low concentration patch (capsaicin 0,04%, 3,2 mg/cm2)
- Where
- 6 sites in France
- Volunteers
- 188 people
- Sponsor
- Nantes University Hospital
Heart Diseases, Heart Failure
Echocardiography in Nursing Home
The study seeks to explore the implementation characteristics (acceptability, appropriateness, feasibility, adoption, fidelity, penetration, implementation cost and sustainability) of systematic echocardiography in nursing homes…
- Conditions
- Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- ECHOGER (NCT06445231)
- Testing
- Implementation of echocardiography in nursing homes
- Where
- France
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Pediatric Cancer, Palliative Care
Integration of Palliative Care in Pediatric Onco-hematology
PALONCOPED is a multicentre, interregional, observational and qualitative study aiming to better understand the early integration of palliative care in children with cancer.
- Trial name
- PALONCOPED (NCT07838168)
- Testing
- PALONCOPED semi-structured interview
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Lung Cancer, Carcinoma, Non-Small-Cell Lung
Prospective, Longitudinal Biocollection in Thoracic Oncology, Including Newly Diagnosed Lung Cancer Patients
In clinical trials, patients are selected according to strict eligibility criteria (inclusion and exclusion criteria). These criteria aim to ensure homogeneity within the trial population, but may omit patients with specific…
- Conditions
- Lung Cancer, Carcinoma, Non-Small-Cell Lung, Small Cell Lung Carcinoma, Metastatic Lung Cancer
- Trial name
- BREATHE (NCT06481813)
- Testing
- Blood Sampling (2*8mL Tubes), PBMC Sampling (1*8mL Tubes), Paxgene Sampling
- Where
- 4 sites in France
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital