Research institution
The Hospital for Sick Children Clinical Trials
Studies where The Hospital for Sick Children is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 78Maternal Nutrition, Child Nutrition
Climate-Responsive Nutrition, WASH, and Heat Counselling for Maternal and Child Health in Sindh, Pakistan
The goal of this trial is to evaluate whether a climate- and gender-responsive integrated package of nutrition, hygiene (WASH), and heat-adaptation counselling can improve maternal and child health and nutrition outcomes among…
- Trial name
- IGNIT3 (NCT07819994)
- Testing
- Training of Lady Health Workers (LHWs), Training of Healthcare Providers (HCPs) at Facilities
- Where
- Pakistan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Congenital Heart Disease (CHD), Mentorship
Optimizing Care Transitions in CHD
Adolescents and young adults (AYA) with congenital heart disease (CHD) face psychosocial stresses as they transition to adult care. Parents of AYA with CHD also experience increased caregiver burden and psychosocial stresses.
- Conditions
- Congenital Heart Disease (CHD), Mentorship, Transition of Care, Peer Support
- Trial name
- NCT07898384
- Testing
- Peer mentorship
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Heart Failure
Exploratory Study on Bio-signal Telemonitoring Using Electronic Textiles in a Pediatric Acute and Critical Care Setting
The primary research objective is to determine the safety, feasibility, usability and validity of textile-enabled monitoring systems designed to capture physiologic variables, or "biological signals," related to cardiopulmonary…
- Trial name
- NCT05961176
- Testing
- Skiin pediatric band and Skiin biometric pod
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Hemophilia
3D Ultrasound in Hemophilic Ankles
The study examines whether a mechanical arm ultrasound system provides diagnostic accuracy comparable to expert-performed full ultrasound for detecting key joint components and whether it can reduce acquisition variability…
- Trial name
- NCT07452575
- Testing
- Mechanical Ultrasound
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- The Hospital for Sick Children
Neurofibromatosis 1 (NF1), Executive Function (Cognition)
Cognitive Intervention for Children and Adolescents With NF1
Psychological interventions have been shown to be effective for managing cognitive and mental health challenges in different patient populations.
- Conditions
- Neurofibromatosis 1 (NF1), Executive Function (Cognition), Cognitive Intervention
- Trial name
- NCT07869914
- Testing
- Unstuck and On Target!
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Lupus
Exploring Biological Mechanisms Underlying the TEACH Intervention for Adolescents With Lupus
This study aims to understand how the TEACH program helps improve mental health and well-being in adolescents with childhood-onset lupus.
- Trial name
- NCT07771088
- Testing
- TEACH
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Inflammatory Bowel Diseases, Crohn's
The Canadian Children Inflammatory Bowel Disease Network (CIDsCaNN)
The CIDsCaNN Network is being established with the major goals of identifying why IBD develops so commonly in children and adolescents living in Canada, and of determining the best treatment strategies for different types of IBD.
- Conditions
- Inflammatory Bowel Diseases, Crohn's, Ulcerative Colitis
- Trial name
- CIDsCaNN (NCT02308917)
- Where
- 12 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- The Hospital for Sick Children
Neonatal Patients Undergoing Major Non-cardiac Surgery, Congenital Anomaly
Neonatal Enhanced Recovery After Surgery (ERAS) Outcomes Study
The goal of this observational study is to improve the way newborn babies are cared for before, during, and after major surgery. Surgery can be very stressful on a baby's body.
- Trial name
- NEO (NCT07771478)
- Testing
- Pre-nERAS Guideline Implementation Intervention, Multifaceted Implementation of nERAS Guideline Intervention
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 400 people
- Sponsor
- The Hospital for Sick Children
Developmental Dysplasia of Hip, DDH
8 vs 12 Weeks: A Pavlik Harness Trial
Developmental dysplasia of the hip is the most common bone and joint condition in babies. It is usually treated with a harness that holds the hips in a safe position so they can develop normally.
- Conditions
- Developmental Dysplasia of Hip, DDH, Developmental Dysplasia of the Hip, Developmental Dysplasia of the Hip (DDH)
- Trial name
- NCT07847619
- Testing
- Pavlik Harness
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Evaluation of Mainstreamed Models of Genetic Service Delivery, Genetic Disease
Implementation-effectiveness Trial of Mainstreaming of Clinical Genomic Sequencing for Rare Disease in Ontario, Canada
Genomic sequencing (GS) is increasingly recommended as a diagnostic test for patients with suspected genetic disorders, but access often remains limited to those referred to medical geneticists.
- Conditions
- Evaluation of Mainstreamed Models of Genetic Service Delivery, Genetic Disease, Neurodevelomental Disorders
- Trial name
- NCT07799792
- Testing
- Genome-wide Sequencing Ordering
- Volunteers
- 100 people
- Sponsor
- The Hospital for Sick Children
Completed, with results posted
All 31Non-anemic Iron Deficiency
Iron Treatment for Young Children With Non-anemic Iron Deficiency
The pre-school years are critical years for children to acquire early learning skills such as language, fine motor and social skills; this is termed early child development.
- Trial name
- OptEC (NCT01481766)
- Testing
- Ferrous Sulfate, Dietary counseling
- Where
- 2 sites in Canada
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Pediatric Cancer, Quality of Life
Symptom Screening Linked to Care Pathways
Most children with cancer survive because they are given intensive treatments, but unfortunately, these treatments are associated with distressing symptoms.
- Trial name
- NCT04614662
- Testing
- SPARK Symptom Screening Linked to Feedback to Providers
- Where
- 21 sites in United States, Canada
- Volunteers
- 445 people
- Sponsor
- The Hospital for Sick Children
Pediatric Oncology, Quality of Life
SPARK Symptom Screening and Feedback to Providers
Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a web-based application which builds upon the Symptom Screening in Pediatrics Tool (SSPedi) and consists of two components: (1) a symptom…
- Trial name
- NCT03593525
- Testing
- SPARK
- Where
- Canada
- Volunteers
- 345 people
- Sponsor
- The Hospital for Sick Children
Clubfoot
Novel Dynamic Foot Abduction Bar for Treatment of Clubfoot
The goal of this clinical trial is to evaluate a new Dynamic Bar for foot abduction bracing for clubfoot treatment. The main questions that this study aims to answer are: How easy is it to recruit and retain participants for a…
- Trial name
- NCT05293743
- Testing
- Foot abduction bracing for clubfoot with novel Dynamic Bar, Foot abduction bracing for clubfoot with Standard Bar
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Crohn's Disease, Ulcerative Colitis
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease
Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Healthy Controls
- Trial name
- NCT03397108
- Testing
- The IBD group was divided into 2 subgroups: with or without anti-TNF antibody use
- Where
- 2 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children