Research institution
University of British Columbia Clinical Trials
Studies where University of British Columbia is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 192OSA COPD Overlap Syndrome
Comparing Two Types of Breathing Support in People With COPD, High Carbon Dioxide Levels, and Sleep Apnea
This pilot study compares two positive airway pressure strategies for patients with both COPD and obstructive sleep apnea (overlap syndrome) who retain excess carbon dioxide.
- Trial name
- PAVE-OVS (NCT07891962)
- Testing
- Bilevel
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Bipolar Disorder (BD), Quality of Life (QOL)
Evaluating the PolarUs App in People With Bipolar Disorder
Our team recently pilot tested a new mobile app, PolarUs, co-designed with people who live with bipolar disorder (BD), to support BD self-management and quality of life (QoL) measurement.
- Trial name
- NCT07890805
- Testing
- PolarUs Mobile App
- Where
- Canada
- Volunteers
- 504 people
- Sponsor
- University of British Columbia
Perimenopause, Subjective Cognitive Complaints
Exercise in Perimenopause to Improve Cognitive Health
Perimenopause is now considered a possible risk factor for dementia and may contribute to the fact that 2/3 of those living with Alzheimer's disease are females.
- Trial name
- EPIC (NCT07272174)
- Testing
- Progressive Resistance Training, Balance, Flexibility, and Tone Exercises
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation (AF)
Optimal PharmacoTherapy and Invasive Management of Atrial Fibrillation in Patients With Heart Failure
Atrial Fibrillation (AF) and Heart Failure (HF) are colliding global cardiovascular epidemics, individually impairing quality of life and cardiac performance, as well as increasing the risk of hospitalisation and mortality.
- Trial name
- OPTIMal AF-HF (NCT07238452)
- Testing
- Pulmonary Vein Isolation, Pharmacological Rate Control
- Volunteers
- 1,050 people
- Sponsor
- University of British Columbia
Urinary Incontinence
Synthetic Versus Autologous Sling For Stress Incontinence
This is a multi-centre randomized controlled trial comparing mid-urethral synthetic mesh sling or tension-free vaginal tape (TVT) and autologous fascia sling (AFS) in elderly patients with stress predominant urinary incontinence.
- Trial name
- SASSI (NCT07276295)
- Testing
- autologous fascia sling, tension-free vaginal tape
- Where
- 7 sites in Canada
- Volunteers
- 232 people
- Sponsor
- University of British Columbia
SCI - Spinal Cord Injury
Cardiocentric Inotropic Optimization in Spinal Cord Injury
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected.
- Trial name
- CARDIO-SCI (NCT07871643)
- Testing
- Dobutamine crossover
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of British Columbia
Healthy Adult
Ivabradine for Heart Rate Reduction During Exercise in Healthy Adults
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume).
- Trial name
- NCT07717710
- Testing
- Ivabradine (single oral dose)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Shared Decision Making, Cesarean Section
Shared Decision-Making During Anesthesia Consent for Elective Cesarean Delivery
Shared decision-making (SDM) is the accepted ethical and legal standard for informed consent, but it is not known how it operates in anesthesia consent for cesarean delivery.
- Conditions
- Shared Decision Making, Cesarean Section, Anesthesia, Obstetrical, Informed Consent
- Trial name
- SDM-Consent (NCT07858084)
- Testing
- Observation of anesthesia consent encounter and postpartum questionnaire
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- University of British Columbia
Healthy Adult Male, Healthy Adult Females
Investigating Sex Differences in Mitochondrial Function and Leg Blood Flow During Exercise
This study will compare mitochondrial function and leg blood flow during exercise in healthy endurance-trained females and males aged 19-35.
- Trial name
- MITOP (NCT07866651)
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Completed, with results posted
All –Hip Osteoarthritis
Feasibility of the Hip Instructional Prehabilitation Program for Enhanced Recovery (HIPPER)
Osteoarthritis (OA), leading to hip replacement, is a leading contributor to global mobility impairment. Given the boom in the older demographic it is not surprising that there is an 11% increased demand for replacement every 5…
- Trial name
- HIPPER (NCT02969512)
- Testing
- HIPPER, OASIS Online Educational Webinars
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- University of British Columbia
Joint Disease, Rheumatoid Arthritis
an On-demand Program to EmpoweR Active Self-management (OPERAS)
Self-management is a key component of successful chronic disease management and patients can benefit from learning about how daily activities and treatments relate to their symptoms and health status on an ongoing basis.
- Trial name
- OPERAS (NCT03404245)
- Testing
- Education, Fitbit/self-management app, physiotherapist counselling., Same intervention with a 6 month delay
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- University of British Columbia
Joint Diseases, Knee Osteoarthritis
SuPRA: Using Wearable Activity Trackers With a New Application to Improve Physical Activity in Knee Osteoarthritis
Physical activity is an essential first-line treatment for patients with knee osteoarthritis (OA). However, only 13% of patients meet the activity recommendation of 150 minutes or more per week.
- Trial name
- NCT02585323
- Testing
- Education session, Fitbit/FitViz, PT counselling, Same intervention with a 3 month delay
- Where
- 2 sites in Canada
- Volunteers
- 51 people
- Sponsor
- University of British Columbia
Ketosis, Type 2 Diabetes
Exogenous Ketones in Type 2 Diabetes
Exogenous ketone supplements are proposed to have glucose-lowering potential, provide an alternative fuel for the brain and to enhance cognitive function.
- Trial name
- NCT04194450
- Testing
- Ketone monoester
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of British Columbia
Sepsis, Infection
Paediatric Rapid Sepsis Trigger (PRST) Tool
Sepsis is the leading cause of death and disability in children, every hour of delay in treatment is associated with greater organ damage and ultimately death.
- Trial name
- PRST (NCT04304235)
- Testing
- Pediatric Rapid Sepsis Trigger (PRST) tool, Emergency Triage and Treatment (ETAT) guidelines
- Where
- 3 sites in Kenya, Uganda
- Volunteers
- 18,693 people
- Sponsor
- University of British Columbia