Research institution
University of Manchester Clinical Trials
Studies where University of Manchester is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 34Rare Disease, Undiagnosed Disease
EpiSign International: Expanding Epigenomic Testing in Rare Disease
The purpose of this study is to assess the utility of EpiSign software and an integrated DNA methylation and copy number variant (CNV) microarray technology in helping to diagnose individuals with rare diseases.
- Conditions
- Rare Disease, Undiagnosed Disease, Genetic Diseases, Inborn, Congenital Abnormalities
- Trial name
- NCT07839754
- Testing
- Integrated EPIC/CNV microarray with EpiSign analysis, EpiSign analysis with EPIC DNA methylation microarray
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University of Manchester
Psychosis, Schizophrenia Spectrum Disorders
A Case Series of Culturally-adapted CBTp for Black People in the UK
The goal of this case series study is to learn if culturally-adapted cognitive-behavioural therapy is practical, acceptable and safe among Black Sub-Saharan African and Caribbean people experiencing psychosis.
- Trial name
- NCT07252206
- Testing
- Culturally-adapted cognitive-behavioural therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Manchester
Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Left Ventricular Outflow Tract Obstruction
Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial
Hypertrophic obstructive cardiomyopathy (HOCM) is a heritable heart condition that leads to the thickening of the heart muscle and causes obstruction of blood flow, impeding it's ejection from the heart (LVOT obstruction).
- Conditions
- Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Left Ventricular Outflow Tract Obstruction, Myocardial Ischaemia
- Trial name
- PEACH (NCT07120776)
- Testing
- Camzyos (Mavacamten)
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Manchester
Bladder (Urothelial, Transitional Cell) Cancer, Prostate Cancer
Selecting Hypoxic Tumours for Treatment Modification
Approximately 50% of cancer patients with solid tumours will be treated with radiotherapy. A significant proportion (>25%) of patients have hypoxic tumours which respond poorly to radiotherapy.
- Trial name
- SELECT (NCT06787053)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Manchester
Cancer
MR-BIO: A Study to Evaluate Changes in MR Imaging and Biological Parameters
The MR BIO study aims to understand the changes in the tumour and normal tissues during a course of radiotherapy. This is accomplished by studying the MR images taken during each treatment session on the MR Linear accelerator (MR…
- Trial name
- MR-BIO (NCT04903236)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Chondral Defect
The Biomechanical Outcomes of Autologous Chondrocyte Implantation
Injury to the knee can damage the lining of the knee's bones, called cartilage. Cartilage injuries cause pain and limit movement, making activities like walking, playing sports, and working difficult.
- Trial name
- NCT06921889
- Testing
- Autologous Chondrocyte Implantation (ACI)
- Where
- 7 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Manchester
Hypertrophic Cardiomyopathy (HCM)
Multicentre Hypertrophic Cardiomyopathy Registry
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart condition, affecting approximately 1 in 500 people. It causes the heart muscle to thicken, which can lead to blockages in blood flow (left ventricular outflow…
- Trial name
- NCT07381894
- Where
- United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- University of Manchester
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Patient Safety Concerns
Using IF-THEN Plans to Support Healthcare Professionals in Raising Patient Safety Concerns
This study aims to test whether a brief behavioural intervention can help healthcare professionals raise and respond to patient safety concerns in their work.
- Trial name
- NCT07506096
- Testing
- Implementation intention planning
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Stillbirth, Perinatal Death
A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death
The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible.
- Conditions
- Stillbirth, Perinatal Death, Psychological, Grief
- Trial name
- PEARL-C (NCT07494760)
- Testing
- Bereavement Counselling, Usual bereavement care
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Completed, with results posted
All 5Physical Activity, Aging
A Study of Physical Activity paTTerns and Major Health Events in Older People With Implantable Cardiac Devices
An observational study of physical activity patterns in 150 older adults with cardiac implantable electronic devices (CIED)
- Conditions
- Physical Activity, Aging, Cardiac Disease
- Trial name
- PATTErn (NCT03544424)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 183 people
- Sponsor
- University of Manchester
Functional Neurological Disorder
Body Signal Integration Training: A Case Series
The goal of this clinical trial is to learn about an intervention package in individuals with Functional Neurological Disorder (FND).
- Trial name
- NCT05941702
- Testing
- Body Signal Integration Training
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Manchester
Self Injurious Behaviour
Skin Camouflage for Women Prisoners With Self-Harm Scarring
Women prisoners are more likely to commit suicide or self-harm than women in the community or male prisoners. Healthcare services have improved how they manage self-harm in the community and prisons.
- Trial name
- COVER (NCT02638974)
- Testing
- Medical Skin Camouflage
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- University of Manchester
Stillbirth
The Midlands and North of England Stillbirth Study
The United Kingdom has one of the highest rates of stillbirth in Europe, with more than 4,000 stillbirths every year; which equates to more than 11 deaths every day.
- Trial name
- MiNESS (NCT02025530)
- Testing
- Questionnaire
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,030 people
- Sponsor
- University of Manchester
Postoperative Pain, Wisdom Tooth
Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery
The purpose of this study is to investigate whether robust analgesic regime (protective analgesia) can improve postoperative pain experience for patients undergoing lower wisdom teeth extraction under day case general anaesthetic.
- Trial name
- NCT00895843
- Testing
- Brufen retard, ibuprofen, Bupivacaine
- Where
- 2 sites in United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Manchester