Clinical trials: sponsored by University of Manchester
Dementia, Abuse Client
Partnership in Safeguarding People With Dementia From Primary and Social Care Perspectives
"Adult safeguarding is everyone's responsibility". The Care Act 2014 makes safeguarding a legal duty. It provides local authorities and other agencies in England with a responsibility to protect adults with care and support needs…
- Conditions
- Dementia, Abuse Client, Neglect; Care, Malnutrition
- Trial name
- NCT05883527
- Testing
- Not applicable as not an intervention - PLwD and family/carers, Not applicable as not an intervention - HCP's
- Where
- 5 sites in United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
Type 2 Diabetes, Chronic Kidney Disease 5D
A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis
Diabetes is the leading cause of kidney failure in the UK. Many people with diabetes and advanced kidney failure inject themselves with insulin and do finger-prick blood glucose tests.
- Trial name
- AID-HD (NCT07422532)
- Testing
- Omnipod 5, Insulin injections
- Where
- 4 sites in United Kingdom
- Volunteers
- 84 people
- Sponsor
- Imperial College London
Prostate Cancer, mHSPC
Evaluating Hormone Therapy to Achieve Optimal Doses in Metastatic Prostate Cancer
The goal of this phase 3 clinical trial is to determine the clinical effectiveness and cost effectiveness of using lower doses of Androgen Receptor Pathway Inhibitors (ARPI) to treat patients with prostate cancer that has spread…
- Conditions
- Prostate Cancer, mHSPC, mCRPC
- Trial name
- ENHANCE (NCT07751133)
- Testing
- Abiraterone, Apalutamide, Enzalutamide or Darolutamide (ARPI therapy) (per standard of care) therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- University College, London
Liver Cirrhosis, Hepatocellular Carcinoma
Real-world Elecsys® GAAD Implementation and Validation to Improve Surveillance and Early Detection of HCC
Patients with liver cirrhosis are at high risk of developing hepatocellular carcinoma (HCC) which implies significant mortality.
- Trial name
- REVISE-HCC (NCT05971108)
- Testing
- Elecsys® GAAD
- Where
- United Kingdom
- Volunteers
- 657 people
- Sponsor
- Manchester University NHS Foundation Trust
Major Depressive Disorder (MDD)
Prescribing the Right Agent for Depression in Adults
Depression is a common mental health problem affecting almost 300 million people worldwide. Antidepressants are recommended as one of the first line treatments for people with moderate-to-severe symptoms of depression.
- Trial name
- PRADA (NCT07796295)
- Testing
- PRADA Tool, PETRUSHKA Tool
- Where
- 3 sites in Ethiopia, Pakistan and 1 more
- Volunteers
- 2,142 people
- Sponsor
- University of Oxford
Anxiety, Cervical Cancer Screening
Cervical Cancer Awareness Education to Aid Confidence and Screening upTake (ACT): A Pilot Randomised Control Trial
Cervical cancer remains a major threat to women's health and wellbeing, with the burden disproportionately concentrated in low- and middle-income countries such as Nigeria, where inadequate awareness, limited access to screening…
- Conditions
- Anxiety, Cervical Cancer Screening, Health Education, Wellbeing
- Trial name
- ACT (NCT07863596)
- Testing
- cervical cancer Awareness education to aid Confidence and screening upTake (ACT), Control group
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Teesside University
Stent Thrombosis
Flow Patterns and Stent Thrombosis
The goal of this observational study is to study the effect of haemodynamic forces on thrombus formation and identify haemodynamic markers that predict stent thrombosis events in patients who have undergone OCT-guided…
- Trial name
- TISIS registry (NCT06700018)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Queen Mary University of London
Rare Disease, Undiagnosed Disease
EpiSign International: Expanding Epigenomic Testing in Rare Disease
The purpose of this study is to assess the utility of EpiSign software and an integrated DNA methylation and copy number variant (CNV) microarray technology in helping to diagnose individuals with rare diseases.
- Conditions
- Rare Disease, Undiagnosed Disease, Genetic Diseases, Inborn, Congenital Abnormalities
- Trial name
- NCT07839754
- Testing
- Integrated EPIC/CNV microarray with EpiSign analysis, EpiSign analysis with EPIC DNA methylation microarray
- Where
- United Kingdom
- Volunteers
- 192 people
- Sponsor
- University of Manchester
Pollen Allergy, Venom Allergy
Identification of B Regulatory Cells by Flow Cytometry
The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients…
- Trial name
- NCT06876506
- Testing
- Venepuncture, Allergen Specific Immunotherapy
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature
Building a Computational Model of Auditory Hallucinations
Some people hear voices or sounds that other people cannot hear; these are called auditory hallucinations. The study aims to understand what is happening in the brain when this occurs and will use brain scans to learn more.
- Conditions
- Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature, Psychosis, SCHIZOPHRENIA 1 (Disorder)
- Trial name
- CLARITY WP1 (NCT07820553)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- King's College London
Polycythemia Vera, Essential Thrombocythemia
Myeloproliferative Neoplasms: an In-depth Case-control Study
There is a paucity of data on the aetiology of myeloproliferative neoplasms (MPNs). The investigators conducted a systematic review of the literature which identified several cohort and case-control studies that have investigated…
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Primary Myelofibrosis
- Trial name
- MOSAICC (NCT01831635)
- Testing
- Methodological pens, Methodological compensation, Methodological trolley tokens
- Where
- 3 sites in United Kingdom
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Cleft Palate
Timing of Primary Surgery for Cleft Palate
This trial is a randomised controlled trial with a parallel design taking place in centres across the UK, Scandinavia and Brazil.
- Trial name
- TOPS (NCT00993551)
- Testing
- primary surgery for cleft palate
- Where
- 23 sites in Brazil, Denmark and 3 more
- Volunteers
- 558 people
- Sponsor
- Kevin Munro
Anxiety, Prostate Cancer
proState Cancer Health Education to pRomote Early sreENing Uptake (SCREEN): A Pilot Randomised Control Trial
Prostate cancer is an issue of significant public health concern. Yet in low- and middle-income countries like Nigeria, men are adversely affected due to factors including poor early prostate cancer screening uptake.
- Conditions
- Anxiety, Prostate Cancer, Health Education, Screening and Brief Interventions
- Trial name
- SCREEN (NCT07800390)
- Testing
- proState Cancer awareness education to pRomote Early screENing uptake, Control group
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Teesside University
Diabetes Mellitus, Foot Ulcer
Impact of Removable Cast Walker Design on Usability for Patients With Diabetic Foot Ulcers
Within their lifetime, over 30% of people living with diabetes will develop a diabetic foot ulcer (DFU), many of which will never heal and may require amputation.
- Trial name
- NCT05415878
- Testing
- RCW design form
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rosalind Franklin University of Medicine and Science
Haematological Malignancy, Malignant Neoplasm
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This clinical trial is looking at two drugs called dabrafenib and trametinib. Dabrafenib and trametinib are approved as standard of care treatment for adult patients with melanoma (a type of skin cancer) or lung cancer and in…
- Conditions
- Haematological Malignancy, Malignant Neoplasm, Lymphoproliferative Disorders, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT07440290)
- Testing
- Dabrafenib, Trametinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Unintentional Burn Injury, Depression
Integrated Case Management for Burns Care in Pakistan
To test whether a culturally adapted multicomponent intervention for improving burns care and patient/family rehabilitation is effective in improving survival among burn victims in Pakistan and is cost-effective.
- Conditions
- Unintentional Burn Injury, Depression, Anxiety, Burns
- Trial name
- BURNS (NCT06559501)
- Testing
- Integrated case manager care
- Where
- 11 sites in Pakistan
- Volunteers
- 1,045 people
- Sponsor
- Pakistan Institute of Living and Learning
Fall Patients
Keep Exercising & Stay Steady: Development and Feasibility of a Health Intervention to Encourage Exercise Maintenance After Fall Prevention Exercise Programmes End.
Falls and broken bones are a common health problem faced by older adults. Worldwide, one third of adults aged over 65 years old, and half of adults aged over 80 years, fall each year.
- Trial name
- KESS (NCT06447948)
- Testing
- Keep Exercising and Stay Steady
- Where
- 4 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Heart Failure
Monitoring Oedema in Heart Failure to Improve Function and Reduce Hospitalisation Risk
This study will evaluate the Heartfelt device, a novel, passive monitoring system that detects early signs of fluid build-up in patients (oedema) with heart failure by measuring changes in foot and lower leg volume through…
- Trial name
- ME-HF (NCT07067658)
- Testing
- Installation of Heartfelt Device, Enhanced Standard care, Questionnaires
- Where
- 18 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- Heartfelt Technologies
Mental Health, Oral Health Care
The Mouth Matters in Mental Health Trial -2
This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment.
- Conditions
- Mental Health, Oral Health Care, Psychosis
- Trial name
- NCT07470437
- Testing
- Link work intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 480 people
- Sponsor
- Lancashire and South Cumbria NHS Foundation Trust