Research institution
University of Oklahoma Clinical Trials
Studies where University of Oklahoma is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 91Pancreas Cancer
ctDNA Assay in Patients With Resectable Pancreatic Cancer
The purpose of this study is to determine the proportion of positive ctDNA -freely circulating tumor DNA fragments found in the blood plasma- in patients with pancreatic cancer and to better understand the relationship between…
- Trial name
- OU-SCC-ctDNA (NCT05052671)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Breast Cancer, Lymphoma
Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy
This study is to determine if low level vagus nerve stimulation will lead to improvement in heart function, heart rate variation, and in the levels of certain chemical markers of inflammation in study participants' blood.
- Trial name
- OU-SCC-NCAN (NCT05921253)
- Testing
- PARASYM neuromodulation device
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Oklahoma
Head and Neck Cancer
Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse
This 2-arm phase II study proposes to determine the efficacy of ketamine oral rinse in pain relief from mucositis in head and neck cancer patients undergoing radiation treatment.
- Trial name
- NCT06660017
- Testing
- Ketamine Topical
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Oklahoma
Patient Outcomes
Program in Oncology for Tribal Health Systems.
This clinical trial aims to develop and implement more navigation assistance programs tailored specifically for Native American cancer patients, addressing the current lack of available support.
- Trial name
- NCT07217574
- Testing
- C3PO
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- University of Oklahoma
Prostate Cancer, Renal Cell Carcinoma (RCC)
Characterizing the Genomic Landscape of Cancer in Native American Populations (NAT-Geno)
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prespecified cancers of interest.
- Trial name
- NCT06960798
- Testing
- Bio-specimen Collection, Blood Draw
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Proton Therapy, Radiation Therapy, Secondary Skin Reactions
Protoacoustic Imaging For 3D Mapping
The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy.
- Conditions
- Proton Therapy, Radiation Therapy, Secondary Skin Reactions, Liver Cancer, Prostate Cancer
- Trial name
- NCT07832617
- Testing
- Radiacoustic Imaging w/Ultrasound.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Oklahoma
Breast Cancer
Biopsy-site-marker in Breast Cancer
The purpose of this study is to explore pro-metastatic changes in breast cancer (BC) associated with the stiffness of biopsy site markers.
- Trial name
- NCT07833566
- Testing
- Biopsy-Site Marker Placement.
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Oklahoma
Pancreatic Ductal Adenocarcinoma (PDAC)
Modified FOLFIRINOX and Pentamidine in Advanced and Metastatic Pancreatic Cancer
The purpose of this research is to observe the effects of using a new combination of drugs to inhibit tumor growth.
- Trial name
- FALCON (NCT07829185)
- Testing
- modified FOLFIRINOX, Pentamidine 300 MG Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Oklahoma
Completed, with results posted
All 62Time Restricted Eating
Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults
The central hypothesis of this study is that closer adherence to time restricted eating (TRE) will improve endothelial function, neurovascular (NVC) responses, resulting in improved cognitive performance, potentially through…
- Trial name
- NCT05488652
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Chemotherapy-induced Peripheral Neuropathy
Wearable Focal Vibration for Chemotherapy-Induced Peripheral Neuropathy
This study will perform an early Phase I feasibility study with single-arm, double-baseline repeated measured design. The investigators will test the feasibility of using focal vibration to improve symptoms of persistent CIPN.
- Trial name
- NCT04959929
- Testing
- Focal vibration therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Oklahoma
Missing Teeth
Osseodensification and Implant Survival and Success
Approximately 40 implants from patients seeking treatment at the University of Oklahoma, College of Dentistry will be recruited for this study.
- Trial name
- NCT04741594
- Testing
- Densah
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation
Small Financial Incentives to Promote Smoking Cessation
The primary objectives of this study are 1) to evaluate the longer-term impact of an adjunctive, low-cost financial incentives intervention (relative to standard care) on smoking abstinence rates among socioeconomically…
- Trial name
- PrevailII (NCT02737566)
- Testing
- Standard Care + Financial Incentives, Standard Care
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Oklahoma
Nutrition Poor, Health Behavior
Technical Assistance for Child and Adult Care Food Program in Family Child Care Home
This study evaluates the effect of a nutrition technical assistance training program for family child care home providers on the food they serve young children in their care and the food environment in their home.
- Trial name
- NCT03560050
- Testing
- Nutrition assistance, Children's environmental health/comparison
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma