Clinical trials: sponsored by University of Oklahoma
Pneumonia
Is Osteopathic Manipulative Treatment (OMT) Beneficial for Elderly Patients Hospitalized With Pneumonia?
Osteopathic Manipulative Treatment (OMT) were used in the 1800s and 1900s to treat pneumonia before the introduction of antibiotics in the mid-1900s.
- Trial name
- MOPSE (NCT00258661)
- Testing
- Osteopathic Manipulative Treatment, Light-touch Treatment
- Where
- 7 sites in United States
- Volunteers
- 406 people
- Sponsor
- A.T. Still University of Health Sciences
Neuromodulation
Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study
The Non-invasive Vagus Nerve Stimulation in Patients Undergoing Electrophysiological Study is a single center, pilot, prospective study that aims at evaluating the effects of auricular vagus nerve stimulation (aVNS) on the human…
- Trial name
- VNS-EPS (NCT05350150)
- Testing
- Auricular Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Pancreas Cancer
ctDNA Assay in Patients With Resectable Pancreatic Cancer
The purpose of this study is to determine the proportion of positive ctDNA -freely circulating tumor DNA fragments found in the blood plasma- in patients with pancreatic cancer and to better understand the relationship between…
- Trial name
- OU-SCC-ctDNA (NCT05052671)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
Breast Cancer, Lymphoma
Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy
This study is to determine if low level vagus nerve stimulation will lead to improvement in heart function, heart rate variation, and in the levels of certain chemical markers of inflammation in study participants' blood.
- Trial name
- OU-SCC-NCAN (NCT05921253)
- Testing
- PARASYM neuromodulation device
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Oklahoma
Smoking Cessation
Contingency Management to Promote Smoking Cessation Study
Adherence to medication and counseling are strong predictors of smoking cessation success. To provide these two components of care, healthcare providers typically provide people who smoke with prescriptions for cessation…
- Trial name
- NCT07685899
- Testing
- Health Rewards, Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Tobacco Use Disorder
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily.
- Trial name
- NCT07425119
- Testing
- Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Invasive Breast Carcinoma, Gynecologic Malignancies
Self-Acceptance and Supportive Accountability for Active Living Among Adults Receiving Chemotherapy
Physical activity can improve health-related quality of life among people receiving cancer treatment. Yet, chemotherapy imposes considerable barriers to maintaining an active lifestyle.
- Trial name
- NCT07819045
- Testing
- Acceptance- and Mindfulness-Based Intervention
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Oklahoma
Metastatic Invasive Breast Cancer, Metastatic Invasive Gynecologic Cancer
Promoting Active Living Among People With Advanced Cancer
Individuals with metastatic cancer are living longer but often face persistent fatigue, functional decline, and psychological distress. Physical activity is generally safe for this population and may alleviate symptom burden.
- Trial name
- NCT07238023
- Testing
- Acceptance- and mindfulness-based physical activity promotion
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Oklahoma
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Opioid Overdose (Trial 3 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT07875569
- Testing
- Opioid Overdose Prevention Training
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Gestational Diabetes, Pregnancy, High Risk
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
- Conditions
- Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
- Trial name
- iGDM (NCT05124808)
- Testing
- Intensive glycemic targets, Standard glycemic targets
- Where
- 5 sites in United States
- Volunteers
- 828 people
- Sponsor
- Indiana University
Endometrial Cancer
Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer
This is a single arm, Phase II study using the combination of atezolizumab and bevicacizumab in women with advanced, recurrent or persistent endometrial cancer.
- Trial name
- NCT03526432
- Testing
- Bevacizumab, Atezolizumab
- Where
- 3 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Oklahoma
Head and Neck Cancer
Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse
This 2-arm phase II study proposes to determine the efficacy of ketamine oral rinse in pain relief from mucositis in head and neck cancer patients undergoing radiation treatment.
- Trial name
- NCT06660017
- Testing
- Ketamine Topical
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Oklahoma
Patient Outcomes
Program in Oncology for Tribal Health Systems.
This clinical trial aims to develop and implement more navigation assistance programs tailored specifically for Native American cancer patients, addressing the current lack of available support.
- Trial name
- NCT07217574
- Testing
- C3PO
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- University of Oklahoma
Prostate Cancer, Renal Cell Carcinoma (RCC)
Characterizing the Genomic Landscape of Cancer in Native American Populations (NAT-Geno)
The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prespecified cancers of interest.
- Trial name
- NCT06960798
- Testing
- Bio-specimen Collection, Blood Draw
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Cognitive Coping, Cancer
Evaluating Feasibility and Acceptability of Pain Education
The purpose of this study is to implement a healthy, non-invasive therapeutic alternative for managing cancer-related pain in chronic cancer patients (Cancer Pain 101).
- Trial name
- NCT07869420
- Testing
- Cancer Pain 101, Pharmacotherapy Informational Packet
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Oklahoma
Breast Cancer, Corpus Uteri Cancer
INtegrating Systematic PatIent-Reported Evaluations in Multi-Disciplinary Tumor Boards: The INSPIRE Study
The purpose of the study is to characterize baseline multidisciplinary tumor board (MDTB) context and variability, evaluate the relationship between baseline fitness of patients with cancer and initial treatment recommendations…
- Conditions
- Breast Cancer, Corpus Uteri Cancer, Ovary Cancer, Pancreas Cancer
- Trial name
- INSPIRE (NCT07671937)
- Testing
- INSPIRE (INtegrating Systematic PatIent-Reported Evaluations), Capture of patient-reported outcomes, Enhanced Clinician Awareness
- Where
- 3 sites in United States
- Volunteers
- 2,748 people
- Sponsor
- University of Alabama at Birmingham
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Proton Therapy, Radiation Therapy, Secondary Skin Reactions
Protoacoustic Imaging For 3D Mapping
The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy.
- Conditions
- Proton Therapy, Radiation Therapy, Secondary Skin Reactions, Liver Cancer, Prostate Cancer
- Trial name
- NCT07832617
- Testing
- Radiacoustic Imaging w/Ultrasound.
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Oklahoma
Atrial Fibrillation
Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery.
- Trial name
- STOP_AF (NCT04514757)
- Testing
- active tVNS
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- University of California, Los Angeles