StutteringNCT00148161
Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
An observational study of Stuttering, run by University Hospital Muenster at 2 sites in Germany.
Trial summary
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. Read more about this study
- Who is it for?
- Ages 18 years and older, men onlyHealthy volunteers can take part
- Conditions the study is for
- Stuttering
- How many people
- 20 participants
- Where
- 2 sitesGermany
- Study dates
- Nov 2004to not given
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Men only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Subjects with idiopathic stuttering (for the group of stutterers)
- Fluently speaking subjects (for the control group)
- Right handed
- Normal hearing
Who cannot join
- Neurological diseases
- Psychiatric diseases
- Medication with neurological effective drugs
- Implants with magnetic impact
Trial locations and contacts
2 sites in 1 country.
Germany2 sites, 2 recruiting
- Recruiting
Institute for Biomagnetism and Biosignalanalysis
Münster, 48149
Christo Pantev, Prof. Dr., +49(0)251 83 ext. 56865, pantev@uni-muenster.de
Christo Pantev, Prof. Dr.
- Recruiting
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Münster, 48161
Antoinette G Dinnesen, Prof. Dr., +49(0)251 83 ext. 56859, a.g.dinnesen@uni-muenster.de
Antoinette G Dinnesen, Prof. Dr.
About this study
Official title: Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.
Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.
Read more
Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
- Conditions
- Stuttering
- Keywords
- Magnetoencephalography, Auditory cortex, Stuttering, Non stuttering
- Medical subject headings
- Stuttering
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Sep 2005 (estimated)
- Study startNov 2004
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StutteringStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Defined population
- Time perspective
- Other
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Muenster
- Sponsor type
- University, hospital or other
- Investigators
- Antoinette G Dinnesen, Prof. Dr., Study director, Department of Phoniatrics and Pediatric Audiology, University Hospital MünsterArne Knief, Dr., Principal investigator, Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00148161
- Sponsor's protocol ID
- phonpaed001
- Status last verified
- Sep 2006
- First submitted
- 6 Sep 2005
- Last updated
- 27 Apr 2007
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Apr 2007. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering
- ClinicalTrials.gov ID
- NCT00148161
- Acronym / sponsor ID
- phonpaed001
- Conditions
- Stuttering
- Keywords
- Magnetoencephalography, Auditory cortex, Stuttering, Non stuttering
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University Hospital MuensterUniversity, hospital or other
- Study start
- Nov 2004
- First posted
- 7 Sep 2005 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.
Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.
Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.
The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
Study design
- Observational model
- Defined population
- Time perspective
- Other
Who may qualify
- Ages
- 18 years and older
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Subjects with idiopathic stuttering (for the group of stutterers)
- Fluently speaking subjects (for the control group)
- Right handed
- Normal hearing
Key exclusion criteria (4 listed)
- Neurological diseases
- Psychiatric diseases
- Medication with neurological effective drugs
- Implants with magnetic impact
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Apr 2007.
- Homepage of the Institute for Biomagnetism and BiosignalanalysisLink provided by the sponsor.
Related trials for Stuttering
Recruiting
Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter
Stuttering, Fluency Disorder
Recruiting
Network Connectivity and Temporal Processing in Adolescents Who Stutter
Stuttering, Childhood, Stuttering
Recruiting
Transcranial Alternating Current Stimulation (tACS) in Stuttering
Stuttering, Adult, Stuttering, Childhood
Not yet recruiting
Effectiveness of Virtually Simulated Intervention for Patients Having Stuttering
Stuttering
Not yet recruiting
Development and Pilot Testing of Virtually Simulated Intervention for Patients Having Stuttering
Stuttering
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Antoinette G Dinnesen, Prof. Dr. study director
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
Arne Knief, Dr. principal investigator
Department of Phoniatrics and Pediatric Audiology, University Hospital Münster
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stuttering, run by University Hospital Muenster at 2 sites in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 27 Apr 2007. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Antoinette G Dinnesen, Prof. Dr. (+49(0)251 83 ext. 56859, a.g.dinnesen@uni-muenster.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Apr 2007.