Clinical trials: Stuttering
Stuttering, Fluency Disorder
Using Non-invasive Brain Stimulation to Explore Potential Treatments to Reduce Speech Errors in Adults Who Stutter
The goal of this study is to find out whether a type of noninvasive brain stimulation can help reduce speech errors, such as repetitions, blocks, and prolongations, in people who stutter.
- Trial name
- NCT07354139
- Testing
- High - Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas at Dallas
Stuttering, Childhood, Stuttering
Network Connectivity and Temporal Processing in Adolescents Who Stutter
The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter.
- Trial name
- NCT05286151
- Testing
- Rhythm discrimination
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stuttering, Adult, Stuttering, Childhood
Transcranial Alternating Current Stimulation (tACS) in Stuttering
The purpose of this study is to investigate how mild, noninvasive electrical brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people that…
- Conditions
- Stuttering, Adult, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06740968
- Testing
- transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Stuttering
Effectiveness of Virtually Simulated Intervention for Patients Having Stuttering
This randomized controlled trial aims to evaluate the effectiveness of a culturally appropriate virtual reality (VR)-based speech restructuring intervention for individuals with stuttering in Pakistan.
- Trial name
- NCT07844278
- Testing
- Virtually Simulated Intervention, Traditional Speech Therapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Childhood-Onset Fluency Disorder (Stuttering)
Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 exploratory study in adult subjects with childhood onset fluency disorder.
- Trial name
- NCT04492956
- Testing
- Ecopipam
- Where
- 9 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emalex Biosciences Inc.
Stuttering
Development and Pilot Testing of Virtually Simulated Intervention for Patients Having Stuttering
This study aims to develop and pilot test a culturally appropriate virtual reality (VR)-based speech restructuring intervention for individuals with stuttering in Pakistan.
- Trial name
- NCT07833969
- Testing
- Virtually Simulated Intervention
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Riphah International University
Stuttering
Large Language Models for Stuttering Assessment and Therapy
This observational study aims to compare the quality of responses generated by four large language models (ChatGPT, Claude, Google Gemini, and Grok-4.20) to questions about stuttering.
- Trial name
- NCT07835347
- Testing
- ChatGPT-Generated Responses, Claude-Generated Responses, Google Gemini-Generated Responses
- Where
- Turkey (Türkiye)
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Stuttering, Developmental Stuttering
Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering
This research is studying the use of low-intensity focused ultrasound (LIFU; a mild, noninvasive acoustic stimulation technique) in a small number of people to learn about its safety as a treatment for stuttering.
- Trial name
- NCT07668882
- Testing
- High DC LIFU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Stuttering
Stuttering and Neuromodulation
The purpose of this study is to collect preliminary data on the efficacy of transcranial direct current stimulation (tDCS) combined with traditional behavioral techniques to reduce stuttering severity and negative impact in…
- Trial name
- NCT07222163
- Testing
- Soterix Medical 1x1 tDCS system, Speech therapy sessions
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Stuttering, Childhood
Speech Signals in Stuttering
The purpose of this research study is to understand how speech and language are processed in the brain. This study will provide information that may help with the understanding how speech and language are processed in children…
- Trial name
- NCT05668923
- Testing
- Speech sound stimulation
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Stuttering, Adult
Dopamine and Sensorimotor Function in Stuttering
This study is being done to understand the effect of aripiprazole on adults who stutter. Stuttering is a disorder that affects speech fluency.
- Trial name
- NCT07215884
- Testing
- Aripiprazole 10 MG
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stuttering
Desensitization-Based Structured Intervention Program for Individuals With Stuttering
Stuttering is a common fluency disorder characterized by involuntary interruptions in speech flow, such as repetitions, prolongations, and blocks.
- Trial name
- NCT07764419
- Testing
- Structured Desensitization-Based Job Interview Program
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- DİLARA BASER
Stuttering, Adult
Using Transcranial Magnetic Stimulation to Treat Stuttering
The goal of this clinical trial is to learn if repeated transcranial magnetic stimuli (rTMS) can treat stuttering in adults. The main questions it aims to answer are: Will there be changes in the brains of people who stutter…
- Trial name
- NCT07389694
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kansas State University
Stuttering, Adult
Lumateperone in the Treatment of Stuttering, Childhood Onset Fluency Disorder
The primary objective of this study is to evaluate the efficacy and tolerability of Lumateperone in reducing stuttering symptoms. The following scales and samples will be collected for clinical and functional outcomes.
- Trial name
- NCT07734103
- Testing
- Lumateperone (ITI-007)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- CSTrials Inc.
Stuttering, Developmental, Aphasia, Primary Progressive
Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech
Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life.
- Trial name
- NCT05437159
- Testing
- Learning of non-native phoneme combinations: 6 training sessions, Learning of non-native phoneme combinations: 1 training session, Learning of novel multisyllabic nonwords
- Where
- 3 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Stuttering, Developmental, Dyslexia
Investigating Individual Differences in Speech Motor Skills in Neurotypical Speakers and Persons With Disordered Speech
This study aims to understand how people use different types of feedback to control their speech. When an individual speaks, the brain relies on several systems at the same time, such as sensory systems that monitor an…
- Conditions
- Stuttering, Developmental, Dyslexia, Healthy Participants
- Trial name
- NCT07459803
- Testing
- Unpredictable auditory feedback perturbation: 2 behavioral sessions, Unpredictable auditory feedback perturbation during tCS: 3 behavioral sessions, Sustained F1 auditory feedback perturbation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Stuttering, Stuttering, Childhood
Speech Processing in Stuttering
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Adult
- Trial name
- NCT04929184
- Testing
- Speech and non-speech tasks
- Where
- 2 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stuttering, Adult
Effects of Altered Auditory Feedback on Speech Fluency
The purpose of the study is to use altered auditory vocal feedback to increase fluency in people who stutter and to examine changes in this effect over the course of a one month period occurring outside the laboratory setting.
- Trial name
- NCT06011837
- Testing
- Altered Auditory Feedback
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts Institute of Technology
Stutter, Stuttering, Adult
Organization and Development of Motor Cortical Circuits for Speech Production in Stuttering
The overall objective of this study is to examine inter effector areas (IEAs) activity and functional connectivity during continuous speech production in stuttering adults.
- Conditions
- Stutter, Stuttering, Adult, Stuttering, Stuttering, Developmental
- Trial name
- NCT07180628
- Testing
- Speech Production During functional magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Stuttering, Stuttering, Childhood
The Development of Stuttering in Young Children
The goal of this longitudinal research is to learn why some children "grow out" of stuttering, while others persist. Children who do and do not stutter aged 3-6 years are eligible to participate in our study.
- Conditions
- Stuttering, Stuttering, Childhood, Stuttering, Developmental
- Trial name
- NCT06578416
- Testing
- Standardized assessments of speech and language abilities
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Michigan State University