PainNCT00233844
Studying the Analgesic Mechanism of the "Cough-trick"
A study testing Venipuncture with "cough-trick" in people with Pain and Acute Pain, run by University Medicine Greifswald.
Trial summary
The aim of the trial is to study the possible mechanism of the pain reducing effect of CT at peripheral venipuncture Read more about this study
- Who is it for?
- Ages 20 to 35 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Pain, Acute Pain, Venipuncture
- What is being tested?
- Venipuncture with "cough-trick"
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- No sites listed yet
- Study dates
- Feb 2004to 30 Mar 2008
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 35 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male volunteers aged 20-40 years, height 165-190 cm.
- Physical status I according to American Society of Anesthesiologists (ASA) classification.
- Straight run of the vein on the dorsum of the non-dominant hand at least 4 cm long and 3 mm thick
- No analgesics, anticoagulants and/or antiplatelet agents, sedatives or alcohol
Who cannot join
- History of peripheral neuropathy
- Abnormal skin conditions (infection, scars, psoriasis, eczema)
- Unsuccessful venipuncture
- Inflamed site of VP within 1 week after VP
About this study
Official title: Studying the Analgesic Mechanism of the "Cough-trick" - Randomized Crossover Volunteer Study
The aim of the trial is to study the possible mechanism of the pain reducing effect of CT at peripheral venipuncture
- Conditions
- Pain, Acute Pain, Venipuncture
- Being tested
- Venipuncture with "cough-trick"
- Keywords
- Acute pain, pain on venipuncture, "cough-trick", distraction
- Medical subject headings
- Pain, Acute Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Venipuncture with "cough-trick"Procedure or surgery
| Study group | Role | What they receive |
|---|---|---|
| cough-trick | Experimental | Venipuncture with cough-trick technique Receives: Procedure: Venipuncture with "cough-trick" |
| without cough trick | No intervention | Venipuncture without cough-trick technique |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity measured on 100 mm Visual Analogue Scale scale (VAS-100) where 0 = no pain and 100 = maximal pain
Measured: immediately during venipuncture
Secondary outcomes (1)
Heart rate, beats per minute
Measured: 5 min during venipuncture
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Oct 2005 (estimated)
- Study startFeb 2004
- Primary completion30 Mar 2008
- Study completion30 Mar 2008
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Medicine Greifswald
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Taras I. Usichenko, Assistant Professor, Principal investigator, Anesthesiology and Intensive Care Medicine Department, Ernst Moritz Arndt University of Greifswald, Germany
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00233844
- Sponsor's protocol ID
- III UV 82/03
- Status last verified
- Jun 2026
- First submitted
- 5 Oct 2005
- Last updated
- 11 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Studying the Analgesic Mechanism of the "Cough-trick" - Randomized Crossover Volunteer Study
- ClinicalTrials.gov ID
- NCT00233844
- Acronym / sponsor ID
- III UV 82/03
- Conditions
- Pain, Acute Pain, Venipuncture
- Keywords
- Acute pain, pain on venipuncture, "cough-trick", distraction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- University Medicine GreifswaldUniversity, hospital or other
- Study start
- Feb 2004
- Primary completion
- 30 Mar 2008 (actual)
- Study completion
- 30 Mar 2008 (actual)
- First posted
- 6 Oct 2005 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the trial is to study the possible mechanism of the pain reducing effect of CT at peripheral venipuncture
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| cough-trick | Experimental | Procedure: Venipuncture with "cough-trick"Venipuncture with cough-trick technique |
| without cough trick | No intervention | –Venipuncture without cough-trick technique |
Who may qualify
- Ages
- 20 to 35 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Male volunteers aged 20-40 years, height 165-190 cm.
- Physical status I according to American Society of Anesthesiologists (ASA) classification.
- Straight run of the vein on the dorsum of the non-dominant hand at least 4 cm long and 3 mm thick
- No analgesics, anticoagulants and/or antiplatelet agents, sedatives or alcohol
Key exclusion criteria (4 listed)
- History of peripheral neuropathy
- Abnormal skin conditions (infection, scars, psoriasis, eczema)
- Unsuccessful venipuncture
- Inflamed site of VP within 1 week after VP
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Venipuncture with "cough-trick" | Procedure or surgery | cough-trick |
Primary outcome
Pain intensity measured on 100 mm Visual Analogue Scale scale (VAS-100) where 0 = no pain and 100 = maximal pain
Time frame: immediately during venipuncture
1 secondary outcome
Heart rate, beats per minute
Time frame: 5 min during venipuncture
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Taras I. Usichenko, Assistant Professor principal investigator
Anesthesiology and Intensive Care Medicine Department, Ernst Moritz Arndt University of Greifswald, Germany
Questions about this trial
What is this clinical trial studying?
A study testing Venipuncture with "cough-trick" in people with Pain and Acute Pain, run by University Medicine Greifswald.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity measured on 100 mm Visual Analogue Scale scale (VAS-100) where 0 = no pain and 100 = maximal pain (time frame: immediately during venipuncture). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Jun 2026.